https://pubmed.ncbi.nlm.nih.gov/29671031/ This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content U.S. flag An official website of the United States government Here's how you know Dot gov The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. Https The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. NIH NLM Logo Log in Show account info Close Account Logged in as: username * Dashboard * Publications * Account settings * Log out Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation pubmed logo Search: [ ] Search Advanced Clipboard User Guide Save Email Send to * Clipboard * My Bibliography * Collections * Citation manager Display options Display options Format [Abstract] Save citation to file Format: [Summary (text) ] Create file Cancel Email citation Subject: 1 selected item: 29671031 - PubMed To: [ ] Format: [Summary ] [ ] MeSH and other data Send email Cancel Add to Collections * ( ) Create a new collection * (*) Add to an existing collection Name your collection: [ ] Name must be less than 100 characters Choose a collection: [] Unable to load your collection due to an error Please try again Add Cancel Add to My Bibliography * ( ) My Bibliography Unable to load your delegates due to an error Please try again Add Cancel Your saved search Name of saved search: [ ] Search terms: [ ] Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons * (*) Yes * ( ) No Email: (change) Frequency: [Monthly] Which day? [The first Sunday ] Which day? [Sunday ] Report format: [Summary ] Send at most: [5 items ] [ ] Send even when there aren't any new results Optional text in email: [ ] Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: [ ] Number of items displayed: [15 ] Create RSS Cancel RSS Link [ ] Copy Full text links full text provider logo Springer full text provider logo White Rose Research Online Full text links Actions Cite Favorites Display options Display options Format [Abstract] Share * * * Permalink [https://pubmed.ncbi.]Copy Page navigation * Title & authors * Abstract * Similar articles * Cited by * References * Publication types * MeSH terms * Substances * Related information * Grant support * LinkOut - more resources [Title & authors ] Diabetologia Actions * Search in PubMed * Search in NLM Catalog * Add to Search . 2018 Jun;61(6):1282-1294. doi: 10.1007/s00125-018-4603-5. Epub 2018 Apr 18. Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a first-degree relative with type 2 diabetes Kelly A Bowden Davies^ 1 2 , Victoria S Sprung^ 3 4 , Juliette A Norman^ 3 4 , Andrew Thompson^ 5 , Katie L Mitchell^ 6 , Jason C G Halford^ 6 , Jo A Harrold^ 6 , John P H Wilding^ 3 7 , Graham J Kemp^ 3 8 , Daniel J Cuthbertson^ 3 4 Affiliations Expand Affiliations * ^1 Musculoskeletal Biology II, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. k.bowden-davies@liverpool.ac.uk. * ^2 Obesity and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, L9 7AL, UK. k.bowden-davies@liverpool.ac.uk. * ^3 Musculoskeletal Biology II, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. * ^4 Obesity and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, L9 7AL, UK. * ^5 Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. * ^6 Department of Psychological Sciences, Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK. * ^7 Eye and Vision Science, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. * ^8 Liverpool Magnetic Resonance Imaging Centre (LiMRIC), University of Liverpool, Liverpool, UK. * PMID: 29671031 * DOI: 10.1007/s00125-018-4603-5 Free article Item in Clipboard Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a first-degree relative with type 2 diabetes Kelly A Bowden Davies et al. Diabetologia. 2018 Jun. Free article Show details Display options Display options Format [Abstract] Diabetologia Actions * Search in PubMed * Search in NLM Catalog * Add to Search . 2018 Jun;61(6):1282-1294. doi: 10.1007/s00125-018-4603-5. Epub 2018 Apr 18. Authors Kelly A Bowden Davies^ 1 2 , Victoria S Sprung^ 3 4 , Juliette A Norman^ 3 4 , Andrew Thompson^ 5 , Katie L Mitchell^ 6 , Jason C G Halford^ 6 , Jo A Harrold^ 6 , John P H Wilding^ 3 7 , Graham J Kemp^ 3 8 , Daniel J Cuthbertson^ 3 4 Affiliations * ^1 Musculoskeletal Biology II, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. k.bowden-davies@liverpool.ac.uk. * ^2 Obesity and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, L9 7AL, UK. k.bowden-davies@liverpool.ac.uk. * ^3 Musculoskeletal Biology II, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. * ^4 Obesity and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, L9 7AL, UK. * ^5 Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. * ^6 Department of Psychological Sciences, Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK. * ^7 Eye and Vision Science, Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK. * ^8 Liverpool Magnetic Resonance Imaging Centre (LiMRIC), University of Liverpool, Liverpool, UK. * PMID: 29671031 * DOI: 10.1007/s00125-018-4603-5 Item in Clipboard Full text links Cite Display options Display options Format [Abstract] Abstract Aims/hypothesis: Low physical activity levels and sedentary behaviour are associated with obesity, insulin resistance and type 2 diabetes. We investigated the effects of a short-term reduction in physical activity with increased sedentary behaviour on metabolic profiles and body composition, comparing the effects in individuals with first-degree relatives with type 2 diabetes (FDR+ve) vs those without (FDR-ve). Methods: Forty-five habitually active participants (16 FDR+ve [10 female, 6 male] and 29 FDR-ve [18 female, 11 male]; age 36 +- 14 years) were assessed at baseline, after 14 days of step reduction and 14 days after resuming normal activity. We determined physical activity (using a SenseWear armband), cardiorespiratory fitness ([Formula: see text]), body composition (dual-energy x-ray absorptiometry/magnetic resonance spectroscopy) and multi-organ insulin sensitivity (OGTT) at each time point. Statistical analysis was performed using a two-factor between-groups ANCOVA, with data presented as mean +- SD or (95% CI). Results: There were no significant between-group differences in physical activity either at baseline or following step reduction. During the step-reduction phase, average daily step count decreased by 10,285 steps (95% CI 9389, 11,182; p < 0.001), a reduction of 81 +- 8%, increasing sedentary time by 223 min/day (151, 295; p < 0.001). Pooling data from both groups, following step reduction there was a significant decrease in whole-body insulin sensitivity (Matsuda index) (p < 0.001), muscle insulin sensitivity index (p < 0.001), cardiorespiratory fitness (p = 0.002) and lower limb lean mass (p = 0.004). Further, there was a significant increase in total body fat (p < 0.001), liver fat (p = 0.001) and LDL-cholesterol (p = 0.013), with a borderline significant increase in NEFA AUC during the OGTT (p = 0.050). Four significant between-group differences were apparent: following step reduction, FDR+ve participants accumulated 1.5% more android fat (0.4, 2.6; p = 0.008) and increased triacylglycerol by 0.3 mmol/l (0.1, 0.6; p = 0.044). After resuming normal activity, FDR+ve participants engaged in lower amounts of vigorous activity (p = 0.006) and had lower muscle insulin sensitivity (p = 0.023). All other changes were reversed with no significant between-group differences. Conclusions/interpretation: A short-term reduction in physical activity with increased sedentary behaviour leads to a reversible reduction in multi-organ insulin sensitivity and cardiorespiratory fitness, with concomitant increases in central and liver fat and dyslipidaemia. The effects are broadly similar in FDR+ve and FDR-ve individuals. Public health recommendations promoting physical activity should incorporate advice to avoid periods of sedentary behaviour. Keywords: Body composition; Cardiorespiratory fitness; Glucose tolerance; Insulin resistance; Liver fat; Physical activity; Sedentary behaviour; Skeletal muscle; Type 2 diabetes. Similar articles * Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives of type 2 diabetic patients. Nyholm B, Nielsen MF, Kristensen K, Nielsen S, Ostergard T, Pedersen SB, Christiansen T, Richelsen B, Jensen MD, Schmitz O. Nyholm B, et al. Eur J Endocrinol. 2004 Feb;150(2):207-14. doi: 10.1530/eje.0.1500207. Eur J Endocrinol. 2004. PMID: 14763919 Clinical Trial. * Physical Activity and Sedentary Time: Association with Metabolic Health and Liver Fat. Bowden Davies KA, Sprung VS, Norman JA, Thompson A, Mitchell KL, Harrold JOA, Finlayson G, Gibbons C, Wilding JPH, Kemp GJ, Hamer M, Cuthbertson DJ. Bowden Davies KA, et al. Med Sci Sports Exerc. 2019 Jun;51(6):1169-1177. doi: 10.1249/MSS.0000000000001901. Med Sci Sports Exerc. 2019. PMID: 30694971 Free PMC article. * Short-Term Physical Inactivity Induces Endothelial Dysfunction. Bowden Davies KA, Norman JA, Thompson A, Mitchell KL, Harrold JA, Halford JCG, Wilding JPH, Kemp GJ, Cuthbertson DJ, Sprung VS. Bowden Davies KA, et al. Front Physiol. 2021 Apr 9;12:659834. doi: 10.3389/fphys.2021.659834. eCollection 2021. Front Physiol. 2021. PMID: 33897466 Free PMC article. * Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Ivy JL. Ivy JL. Sports Med. 1997 Nov;24(5):321-36. doi: 10.2165/ 00007256-199724050-00004. Sports Med. 1997. PMID: 9368278 Review. * Reduced physical activity in young and older adults: metabolic and musculoskeletal implications. Bowden Davies KA, Pickles S, Sprung VS, Kemp GJ, Alam U, Moore DR, Tahrani AA, Cuthbertson DJ. Bowden Davies KA, et al. Ther Adv Endocrinol Metab. 2019 Nov 19;10:2042018819888824. doi: 10.1177/ 2042018819888824. eCollection 2019. Ther Adv Endocrinol Metab. 2019. PMID: 31803464 Free PMC article. Review. See all similar articles Cited by * Detrimental effects of physical inactivity on peripheral and brain vasculature in humans: Insights into mechanisms, long-term health consequences and protective strategies. Daniele A, Lucas SJE, Rendeiro C. Daniele A, et al. Front Physiol. 2022 Sep 27;13:998380. doi: 10.3389/fphys.2022.998380. eCollection 2022. Front Physiol. 2022. PMID: 36237532 Free PMC article. Review. * Physical Activity During Lockdowns Associated with the COVID-19 Pandemic: A Systematic Review and Multilevel Meta-analysis of 173 Studies with 320,636 Participants. Wilke J, Rahlf AL, Fuzeki E, Groneberg DA, Hespanhol L, Mai P, de Oliveira GM, Robbin J, Tan B, Willwacher S, Hollander K, Pillay JD. Wilke J, et al. Sports Med Open. 2022 Oct 11;8(1):125. doi: 10.1186/s40798-022-00515-x. Sports Med Open. 2022. PMID: 36219269 Free PMC article. * Physical Activity Time and Intensity in Physical Education During the COVID-19 Pandemic. Lourenco J, Rodrigues C, Flores F, Soares D. Lourenco J, et al. Percept Mot Skills. 2022 Jun;129(3):946-961. doi: 10.1177/ 00315125221093906. Epub 2022 Apr 14. Percept Mot Skills. 2022. PMID: 35421321 Free PMC article. * Physical activity and depressive symptoms among community-dwelling older adults in the COVID-19 pandemic era: A three-wave cross-lagged study. Li Y, Su S, Luo B, Wang J, Liao S. Li Y, et al. Int J Disaster Risk Reduct. 2022 Feb 15;70:102793. doi: 10.1016/ j.ijdrr.2022.102793. Epub 2022 Jan 10. Int J Disaster Risk Reduct. 2022. PMID: 35036301 Free PMC article. * Sedentary lifestyle and body composition in type 2 diabetes. Li DD, Yang Y, Gao ZY, Zhao LH, Yang X, Xu F, Yu C, Zhang XL, Wang XQ, Wang LH, Su JB. Li DD, et al. Diabetol Metab Syndr. 2022 Jan 15;14(1):8. doi: 10.1186/s13098-021-00778-6. Diabetol Metab Syndr. 2022. PMID: 35033170 Free PMC article. See all "Cited by" articles References 1. 1. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12 - PubMed 2. 1. Diabetologia. 2012 Nov;55(11):2895-905 - PubMed 3. 1. Diabetologia. 2016 Dec;59(12):2527-2545 - PubMed 4. 1. Int J Behav Nutr Phys Act. 2017 Jun 10;14(1):75 - PubMed 5. 1. Diabetologia. 2017 Jan;60(1):7-23 - PubMed Show all 36 references Publication types * Research Support, Non-U.S. Gov't Actions + Search in PubMed + Search in MeSH + Add to Search MeSH terms * Adipose Tissue / physiology Actions + Search in PubMed + Search in MeSH + Add to Search * Adult Actions + Search in PubMed + Search in MeSH + Add to Search * Anthropometry Actions + Search in PubMed + Search in MeSH + Add to Search * Body Composition* Actions + Search in PubMed + Search in MeSH + Add to Search * Diabetes Mellitus, Type 2 / metabolism* Actions + Search in PubMed + Search in MeSH + Add to Search * Exercise* Actions + Search in PubMed + Search in MeSH + Add to Search * Family Health Actions + Search in PubMed + Search in MeSH + Add to Search * Female Actions + Search in PubMed + Search in MeSH + Add to Search * Glucose Tolerance Test Actions + Search in PubMed + Search in MeSH + Add to Search * Humans Actions + Search in PubMed + Search in MeSH + Add to Search * Insulin / metabolism Actions + Search in PubMed + Search in MeSH + Add to Search * Insulin Resistance Actions + Search in PubMed + Search in MeSH + Add to Search * Life Style Actions + Search in PubMed + Search in MeSH + Add to Search * Lipids / blood Actions + Search in PubMed + Search in MeSH + Add to Search * Liver / physiology Actions + Search in PubMed + Search in MeSH + Add to Search * Magnetic Resonance Spectroscopy Actions + Search in PubMed + Search in MeSH + Add to Search * Male Actions + Search in PubMed + Search in MeSH + Add to Search * Middle Aged Actions + Search in PubMed + Search in MeSH + Add to Search * Muscle, Skeletal / physiology Actions + Search in PubMed + Search in MeSH + Add to Search * Physical Fitness / physiology Actions + Search in PubMed + Search in MeSH + Add to Search * Sedentary Behavior* Actions + Search in PubMed + Search in MeSH + Add to Search * Young Adult Actions + Search in PubMed + Search in MeSH + Add to Search Substances * Insulin Actions + Search in PubMed + Search in MeSH + Add to Search * Lipids Actions + Search in PubMed + Search in MeSH + Add to Search Related information * MedGen * PubChem Compound (MeSH Keyword) Grant support * MR/P020941/1/MRC_/Medical Research Council/United Kingdom * 13/0004719/DUK_/Diabetes UK/United Kingdom LinkOut - more resources * Full Text Sources + Springer + White Rose Research Online * Other Literature Sources + scite Smart Citations * Medical + Genetic Alliance + MedlinePlus Consumer Health Information + MedlinePlus Health Information Full text links [x] full text provider logo Springer full text provider logo White Rose Research Online [x] Cite Copy Download .nbib Format: [NLM] Send To * Clipboard * Email * Save * My Bibliography * Collections * Citation Manager [x] NCBI Literature Resources MeSH PMC Bookshelf Disclaimer Follow NCBI Connect with NLM * * * National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894 Web Policies FOIA HHS Vulnerability Disclosure Help Accessibility Careers * NLM * NIH * HHS * USA.gov