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Walt, Department of Pathology, Brigham and Women's Hospital, Wyss Institute for Biologically Inspired Engineering, Harvard University, Harvard Medical School, Boston, MA, 02115, USA (dwalt@bwh.harvard.edu) ORCID logo https://orcid.org/0000-0002-5524-7348 Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, ciac722, https://doi.org/10.1093/cid/ ciac722 Published: 02 September 2022 Article history Received: 05 July 2022 Revision received: 25 August 2022 Accepted: 30 August 2022 Published: 02 September 2022 * pdfPDF * Split View * Views + Article contents + Figures & tables + Video + Audio + Supplementary Data * Cite Cite Zoe Swank, Yasmeen Senussi, Zachary Manickas-Hill, Xu G Yu, Jonathan Z Li, Galit Alter, David R Walt, Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae, Clinical Infectious Diseases, 2022;, ciac722, https://doi.org/ 10.1093/cid/ciac722 Select Format [Select format ] Download citation Close * Permissions Icon Permissions * Share + Email + Twitter + Facebook + More Navbar Search Filter [Clinical Infectious Diseases] Mobile Microsite Search Term [ ] Search * Sign In + Close Navbar Search Filter [Clinical Infectious Diseases] Microsite Search Term [ ] Search Advanced Search Search Menu Abstract The diagnosis of post-acute sequelae of COVID-19 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and COVID-19 patients to quantify viral antigens and inflammatory markers. We detect SARS-CoV-2 spike predominantly in PASC patients up to 12 months post-diagnosis. COVID-19, post-acute sequelae of COVID-19 (PASC), long COVID, SARS-CoV-2 antigens, spike Information Accepted manuscripts Accepted manuscripts are PDF versions of the author's final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. (c) The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https:/ /academic.oup.com/journals/pages/open_access/funder_policies/chorus/ standard_publication_model) (c) The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com Issue Section: Brief Report Download all slides Supplementary data Supplementary data ciac722_Supplementary_Data - zip file Comments 0 Comments Comments (0) Add comment Close comment form modal [ ] I agree to the terms and conditions. You must accept the terms and conditions. Add comment Cancel Submit a comment Name [ ] Affiliations [ ] Comment title [ ] [ ] Comment [ ] You have entered an invalid code Submit Cancel Thank you for submitting a comment on this article. 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