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Source: The Endocrine Society Prenatal exposure to endocrine-disrupting chemicals found in everyday products may interfere with the developing offspring's brain, according to a rat study being presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga. P.S. MohanKumar, Ph.D., professor at the University of Georgia in Athens, Ga., and colleagues, focused on the gestational effects of endocrine-disrupting chemicals bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP), and if they would change stress-related behaviors. "This research is significant because prenatal exposure to these chemicals may contribute to mood disorders later in life," said study co-author Amrita Kaimal, Ph.D., of the University of Georgia Neuroscience Graduate Program. A total of 76 Sprague-Dawley rats were used for the study. After the rats were mated, pregnant female rats were administered oral saline, BPA, a combination of BPA and low-dose DEHP, or a combination of BPA and high-dose DEHP during days 6-21 of pregnancy. All of the doses were adjusted according to the body weight of the rat. Behavioral tests were conducted in adult offspring, and brains from the rats were analyzed for monoamine neurotransmitters, like dopamine and serotonin. Female offspring administered BPA and a combination of BPA and low-dose DEHP displayed less anxiety in the Open Field Test, which measures activity and exploratory behavior. However, male offspring administered high-dose DEHP showed feminized anxiety-like behavior in a maze. This shows a cartoon of a pregnant womanBehavioral tests were conducted in adult offspring, and brains from the rats were analyzed for monoamine neurotransmitters, like dopamine and serotonin. Fear responses among male offspring in most of the groups exposed to endocrine-disrupting chemicals were impaired in a test examining the response to a threatening object. Interestingly, low-dose endocrine disruptors led to passive coping strategies in male and female offspring. See also This shows a brain FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles *December 16, 2021*4 min read Parkinson's Disease Mutation Misdirects Iron in the Brain Brain studies indicate male offspring in the BPA, low-dose and high-dose DEHP, and BPA and high-dose DEHP groups had diminished dopamine levels in the paraventricular hypothalamic nucleus. This is associated with their impaired fear response. "Our study confirms sex-specific behavioral changes in offspring as a result of these exposures, highlighting the fact that exposure to these chemicals should be avoided during pregnancy," MohanKumar said. About this fetal brain development research news Author: Press Office Source: The Endocrine Society Contact: Press Office - The Endocrine Society Image: The image is in the public domain Original Research: The findings will be presented at ENDO 2022 Join our Newsletter [ ][ ][SUBSCRIBE] [ ] I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free. We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time. Tags BPAbrain developmentbrain researchdevelopmental neurosciencedopamine environmental neurosciencefetal developmentmonoamineneurobiology neurodevelopmentNeurosciencepregnancyserotonin ShareTweetShareShareSubmitEmail [5f2dac6] Neuroscience News Neuroscience News posts science research news from labs, universities, hospitals and news departments around the world. 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