https://diabetesjournals.org/diabetes/article-abstract/doi/10.2337/db21-0382/144608/Gut-Microbiota-Regulate-Pancreatic-Growth-Exocrine?redirectedFrom=fulltext Skip to Main Content Umbrella Alt Text Umbrella Alt Text Close * Journals + Journals Home + Diabetes + Diabetes Care + Clinical Diabetes + Diabetes Spectrum + BMJ Open Diabetes Research & Care * Professional Books * ADA Standards of Care * ADA Meeting Abstracts * Clinical Compendia * Podcasts * Professional News Search Dropdown Menu nav search search input [ ] Search input auto suggest [ ] search filter [Diabetes ] Search Advanced Search User Tools Dropdown Register Sign In Diabetes Toggle MenuMenu * Current + Current Issue + Online Ahead of Print + ADA Scientific Sessions Abstracts * Browse + Issue Archive + Saved Searches + ADA Scientific Sessions Abstracts + COVID-19 Article Collection * Info & About + About the Journal + About the Editors + ADA Journal Policies + Instructions for Authors + Guidance for Reviewers + Advertising + Reprints and Permissions * Podcasts + Diabetes Core Update + Special Edition Series: COVID-19 and Diabetes + Special Edition: Painful Diabetic Peripheral Neuropathy + Special Edition Series: Diabetes and Influenza + Special Edition Series: SGLT2 Inhibitors in Type 2 Diabetes: Cardiovascular and Renal Outcomes + Special Edition: SGLT2 Inhibitors and Diabetic Kidney Disease + Special Edition Series: Disrupting Therapeutic Inertia in Diabetes Management * Subscriptions + Individual Subscriptions + Institutional Subscriptions and Site Licenses + Access Institutional Usage Reports * Alerts * Submit + Submit a Manuscript + Submit a Cover Image Skip Nav Destination Article Navigation Close mobile search navigation Article navigation Article Navigation Original Research| February 25 2022 Gut Microbiota Regulate Pancreatic Growth, Exocrine Function and Gut Hormones Khyati Girdhar; Khyati Girdhar 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 Search for other works by this author on: This Site PubMed Google Scholar Marion Soto; Marion Soto 2Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States Search for other works by this author on: This Site PubMed Google Scholar Qian Huang; Qian Huang 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 Search for other works by this author on: This Site PubMed Google Scholar Lucie Orliaguet; Lucie Orliaguet 2Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States 3Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne Universite, USPC, Universite Paris Descartes, Universite Paris Diderot, F-75006, Paris, France Search for other works by this author on: This Site PubMed Google Scholar Carly Cederquist; Carly Cederquist 2Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States Search for other works by this author on: This Site PubMed Google Scholar Bharathi Sundaresh; Bharathi Sundaresh 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 Search for other works by this author on: This Site PubMed Google Scholar Jiang Hu; Jiang Hu 4Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States Search for other works by this author on: This Site PubMed Google Scholar Maximilian Figura; Maximilian Figura 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 Search for other works by this author on: This Site PubMed Google Scholar Amol Raisingani; Amol Raisingani 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 Search for other works by this author on: This Site PubMed Google Scholar Emanuel E. Canfora; Emanuel E. Canfora 5Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Ercument Dirice; Ercument Dirice 4Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States 6Department of Pharmacology, New York Medical College, School of Medicine, Basic Science Building, C21, 15 Dana Road, Valhalla, NY 10595 Search for other works by this author on: This Site PubMed Google Scholar Shiho Fujisaka; Shiho Fujisaka 2Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States 7First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan. Search for other works by this author on: This Site PubMed Google Scholar Gijs H. Goossens; Gijs H. Goossens 5Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Ellen E. Blaak; Ellen E. Blaak 5Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Rohit N. Kulkarni; Rohit N. Kulkarni 4Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States Search for other works by this author on: This Site PubMed Google Scholar C. Ronald Kahn; C. Ronald Kahn 2Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, United States *Correspondence to: Emrah Altindis, Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467. E-mail: altindis@bc.edu and C. Ronald Kahn, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, Phone: (617) 309-2635, Fax: (617) 309-2487, E-mail: c.ronald.kahn@joslin.harvard.edu Search for other works by this author on: This Site PubMed Google Scholar Emrah Altindis Emrah Altindis 1Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467 *Correspondence to: Emrah Altindis, Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467. E-mail: altindis@bc.edu and C. Ronald Kahn, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, Phone: (617) 309-2635, Fax: (617) 309-2487, E-mail: c.ronald.kahn@joslin.harvard.edu Search for other works by this author on: This Site PubMed Google Scholar Crossmark: Check for Updates *Correspondence to: Emrah Altindis, Boston College Biology Department, Higgins Hall, 140 Commonwealth Avenue Chestnut Hill, MA 02467. E-mail: altindis@bc.edu and C. Ronald Kahn, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, Phone: (617) 309-2635, Fax: (617) 309-2487, E-mail: c.ronald.kahn@joslin.harvard.edu Diabetes db210382 https://doi.org/10.2337/db21-0382 Article history Received: January 21 2022 Accepted: February 17 2022 * Views Icon Views + Article contents + Figures & tables + Video + Audio + Supplementary Data + Peer Review * Share Icon Share + Twitter + LinkedIn * Cite Icon Cite * Get Permissions Citation Khyati Girdhar, Marion Soto, Qian Huang, Lucie Orliaguet, Carly Cederquist, Bharathi Sundaresh, Jiang Hu, Maximilian Figura, Amol Raisingani, Emanuel E. Canfora, Ercument Dirice, Shiho Fujisaka, Gijs H. Goossens, Ellen E. Blaak, Rohit N. Kulkarni, C. Ronald Kahn, Emrah Altindis; Gut Microbiota Regulate Pancreatic Growth, Exocrine Function and Gut Hormones. Diabetes 2022; db210382. https://doi.org/ 10.2337/db21-0382 Download citation file: * Ris (Zotero) * Reference Manager * EasyBib * Bookends * Mendeley * Papers * EndNote * RefWorks * BibTex toolbar search Search Dropdown Menu nav search search input [ ] Search input auto suggest [ ] search filter [Diabetes ] Search Advanced Search Growing evidence indicates an important link between gut microbiota, obesity, and metabolic syndrome. Alterations in exocrine pancreatic function are also widely present in patients with diabetes and obesity. To examine this interaction, C57BL/6J mice were fed either a chow diet, high-fat diet (HFD) or HFD plus oral vancomycin or metronidazole to modify the gut microbiome. HFD alone leads to a 40% increase in pancreas weight, decreased glucagon-like peptide-1 and peptide YY levels, and increased glucose-dependent insulinotropic peptide in the plasma. Quantitative proteomics identified 138 host proteins in fecal samples of these mice, of which 32 were significantly changed by HFD. The most significant of these were the pancreatic enzymes. These changes in amylase and elastase were reversed by antibiotic treatment. These alterations could be reproduced by transferring gut microbiota from donor C57BL/6J mice to germ-free. By contrast, antibiotics had no effect on pancreatic size or exocrine function in C57BL/6J mice fed a chow diet. Further, one week vancomycin administration significantly increased amylase and elastase levels in obese prediabetic men. Thus, the alterations in gut microbiota in obesity can alter pancreatic growth, exocrine function and gut endocrine function, and may contribute to the alterations observed in patients with obesity and diabetes. This content is only available via PDF. (c) 2022 by the American Diabetes Association 2022 Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https:// www.diabetesjournals.org/content/license. Article PDF first page preview Article PDF first page preview Article PDF first page preview Close Modal You do not currently have access to this content. Sign in Don't already have an account? Register Client Account You could not be signed in. Please check your email address / username and password and try again. Email address / Username ? 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