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The Genetics of Participation: Method and Analysis

Stefania Benonisdottir, Augustine Kong
doi: https://doi.org/10.1101/2022.02.11.480067
Stefania Benonisdottir
University of Oxford

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Augustine Kong
University of Oxford

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  * For correspondence: augustine.kong@bdi.ox.ac.uk

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Abstract

Participation in a genetic study likely has a genetic component.
Identifying such component is difficult as we cannot compare genetic
information of participants with non-participants directly, the
latter being unavailable. Here, we show that alleles that are more
common in participants than non-participants would be further
enriched in genetic segments shared by two related participants.
Genome-wide analysis was performed by comparing allele frequencies in
shared and not-shared genetic segments of first-degree relative pairs
of the UK Biobank. A polygenic score constructed from that analysis,
in non-overlapping samples, is associated with educational attainment
(P=2.1x10^-52), body mass index (P=1.5x10^-19), and participation in
a dietary study (P=6.9x10^-21). Further analysis shows that
inclination to participate is a behavioural trait in its own right,
and not simply a consequence of other established phenotypes.
Understanding the basis of this trait is important for data analyses
and the design of future surveys, genetic or otherwise.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has
granted bioRxiv a license to display the preprint in perpetuity. It
is made available under a CC-BY-NC-ND 4.0 International license.

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Posted February 14, 2022.
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The Genetics of Participation: Method and Analysis
Stefania Benonisdottir, Augustine Kong
bioRxiv 2022.02.11.480067; doi: https://doi.org/10.1101/
2022.02.11.480067
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The Genetics of Participation: Method and Analysis
Stefania Benonisdottir, Augustine Kong
bioRxiv 2022.02.11.480067; doi: https://doi.org/10.1101/
2022.02.11.480067

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