https://sigallab.net/

 

Sigallab

[Lucaphotography]

Lab interests

Pathogen evolution and long-term persistence including that of
SARS-CoV-2

Effects of HIV co-infection on SARS-CoV-2 and other pathogens

Escape of SARS-CoV-2 variants from the antibody neutralization immune
response elicited by vaccines and other variants

Lab PI and members

Alex Sigal is faculty at the Africa Health Research Institute and
Associate Professor at the University of KwaZulu-Natal. Alex has a
PhD in Systems Biology from the Weizmann Institute and was a
postdoctoral fellow with David Baltimore at the California Institute
of Technology. Sandile Cele, Farina Karim, and Khadija Khan, all from
KwaZulu-Natal, South Africa, are PhD students in the lab and lead
many of the projects. Lab staff are Dr. Laurelle Jackson (Research
Associate), Yashica Ganga (Lab supervisor), Zesuliwe Jule
(Technologist) and Kajal Reedoy (Technologist).

Preprints

Coming...

Publications 2021

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent
plasma. Nature.

HIV status alters disease severity and immune cell responses in beta
variant SARS-CoV-2 infection wave. eLife.

T cell derived HIV-1 is present in the CSF in the face of suppressive
antiretroviral therapy. PLos Pathogens.

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory
Response. Frontiers.

Similar antibody responses against SARS-CoV-2 in HIV uninfected and
infected individuals on antiretroviral therapy during the first South
African infection wave. Clin Infect Dis.

Sixteen novel lineages of SARS-CoV-2 in South Africa. Nat Med.

Detection of a SARS-CoV-2 variant of concern in South Africa. Nature.

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351
Variant. N Engl J Med.

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced
humoral immunity. Cell.

Two doses of SARS-CoV-2 vaccination induce robust immune responses to
emerging SARS-CoV-2 variants of concern. Nature Communications.

Aggregation state of Mycobacterium tuberculosis impacts host immunity
and augments pulmonary disease pathology. Communications Biology.

Reduced antibody cross-reactivity following infection with B.1.1.7
than with parental SARS-CoV-2 strain. eLife.

(c) 2021 . Bento theme by Satori Studio