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HomeCirculationAbstract 10712: Mrna COVID Vaccines Dramatically
Increase Endothelial Inflammatory Markers and ACS Risk as Measured by
the PULS Cardiac Test: a Warning
Free AccessAbstract

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Free AccessAbstract

Arteriosclerosis, Thrombosis, Vascular Biology

Session Title: Damps, Infection and Cardiovascular Metabolism

Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial
Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac
Test: a Warning

  * Steven R Gundry

Steven R Gundry
Steven R Gundry

The International Heart and Lung Institute, Palm Springs, CA

Search for more papers by this author

Originally published8 Nov 2021Circulation. 2021;144:A10712

  * This article has an expression of concern
      + Expression of Concern: Abstract 10712: Mrna COVID Vaccines
        Dramatically Increase Endothelial Inflammatory Markers and
        ACS Risk as Measured by the PULS Cardiac Test: a Warning

Abstract

Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc,
Irvine, CA) a clinically validated measurement of multiple protein
biomarkers which generates a score predicting the 5 yr risk
(percentage chance) of a new Acute Coronary Syndrome (ACS). The score
is based on changes from the norm of multiple protein biomarkers
including IL-16, a proinflammatory cytokine, soluble Fas, an inducer
of apoptosis, and Hepatocyte Growth Factor (HGF)which serves as a
marker for chemotaxis of T-cells into epithelium and cardiac tissue,
among other markers. Elevation above the norm increases the PULS
score, while decreases below the norm lowers the PULS score.The score
has been measured every 3-6 months in our patient population for 8
years. Recently, with the advent of the mRNA COVID 19 vaccines (vac)
by Moderna and Pfizer, dramatic changes in the PULS score became
apparent in most patients.This report summarizes those results. A
total of 566 pts, aged 28 to 97, M:F ratio 1:1 seen in a preventive
cardiology practice had a new PULS test drawn from 2 to 10 weeks
following the 2^nd COVID shot and was compared to the previous PULS
score drawn 3 to 5 months previously pre- shot. Baseline IL-16
increased from 35=/-20 above the norm to 82 =/- 75 above the norm
post-vac; sFas increased from 22+/- 15 above the norm to 46=/-24
above the norm post-vac; HGF increased from 42+/-12 above the norm to
86+/-31 above the norm post-vac. These changes resulted in an
increase of the PULS score from 11% 5 yr ACS risk to 25% 5 yr ACS
risk. At the time of this report, these changes persist for at least
2.5 months post second dose of vac.We conclude that the mRNA vacs
dramatically increase inflammation on the endothelium and T cell
infiltration of cardiac muscle and may account for the observations
of increased thrombosis, cardiomyopathy, and other vascular events
following vaccination.

Footnotes

Author Disclosures: For author disclosure information, please visit
the AHA Scientific Sessions 2021 Online Program Planner and search
for the abstract title.

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      + Expression of Concern: Abstract 10712: Mrna COVID Vaccines
        Dramatically Increase Endothelial Inflammatory Markers and
        ACS Risk as Measured by the PULS Cardiac Test: a Warning
        Circulation;0
  * 

Circulation, volume 144 issue Suppl_1 cover
November 16, 2021
Vol 144, Issue Suppl_1

Article Information

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  * (c) 2021 by American Heart Association, Inc.

  * Originally publishedNovember 8, 2021

[CROSSMARK_Color_hori]
Keywords

  * Acute coronary syndromes
  * Myocarditis
  * Antibodies
  * Inflammation and inflammatory markers
  * COVID-19

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