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[Title & authors         ]
Review
Ageing Res Rev
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. 2017 Nov;40:31-44.
doi: 10.1016/j.arr.2017.08.003. Epub 2017 Aug 10.

Metformin reduces all-cause mortality and diseases of ageing
independent of its effect on diabetes control: A systematic review
and meta-analysis

Jared M Campbell^  1 , Susan M Bellman^  2 , Matthew D Stephenson^  2
, Karolina Lisy^  3
Affiliations Expand

Affiliations

  * ^1 The Joanna Briggs Institute, The University of Adelaide,
    Adelaide, South Australia, Australia; Centre for Nanoscale
    BioPhotonics, Macquarie University, Sydney, New South Wales,
    Australia. Electronic address: Jared.campbell@mq.edu.au.
  * ^2 The Joanna Briggs Institute, The University of Adelaide,
    Adelaide, South Australia, Australia.
  * ^3 Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

  * PMID: 28802803
  * DOI: 10.1016/j.arr.2017.08.003

Item in Clipboard
Review

Metformin reduces all-cause mortality and diseases of ageing
independent of its effect on diabetes control: A systematic review
and meta-analysis

Jared M Campbell et al. Ageing Res Rev. 2017 Nov.
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Ageing Res Rev
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. 2017 Nov;40:31-44.
doi: 10.1016/j.arr.2017.08.003. Epub 2017 Aug 10.

Authors

Jared M Campbell^  1 , Susan M Bellman^  2 , Matthew D Stephenson^  2
, Karolina Lisy^  3

Affiliations

  * ^1 The Joanna Briggs Institute, The University of Adelaide,
    Adelaide, South Australia, Australia; Centre for Nanoscale
    BioPhotonics, Macquarie University, Sydney, New South Wales,
    Australia. Electronic address: Jared.campbell@mq.edu.au.
  * ^2 The Joanna Briggs Institute, The University of Adelaide,
    Adelaide, South Australia, Australia.
  * ^3 Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

  * PMID: 28802803
  * DOI: 10.1016/j.arr.2017.08.003

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Abstract

This systematic review investigated whether the insulin sensitiser
metformin has a geroprotective effect in humans. Pubmed and Embase
were searched along with databases of unpublished studies. Eligible
research investigated the effect of metformin on all-cause mortality
or diseases of ageing relative to non-diabetic populations or
diabetics receiving other therapies with adjustment for disease
control achieved. Overall, 260 full-texts were reviewed and 53 met
the inclusion criteria. Diabetics taking metformin had significantly
lower all-cause mortality than non-diabetics (hazard ratio (HR)=0.93,
95%CI 0.88-0.99), as did diabetics taking metformin compared to
diabetics receiving non-metformin therapies (HR=0.72, 95%CI
0.65-0.80), insulin (HR=0.68, 95%CI 0.63-0.75) or sulphonylurea (HR=
0.80, 95%CI 0.66-0.97). Metformin users also had reduced cancer
compared to non-diabetics (rate ratio=0.94, 95%CI 0.92-0.97) and
cardiovascular disease (CVD) compared to diabetics receiving
non-metformin therapies (HR=0.76, 95%CI 0.66-0.87) or insulin (HR=
0.78, 95%CI 0.73-0.83). Differences in baseline characteristics were
observed which had the potential to bias findings, although
statistical adjustments were made. The apparent reductions in
all-cause mortality and diseases of ageing associated with metformin
use suggest that metformin could be extending life and healthspans by
acting as a geroprotective agent.

Keywords: Geroprotection; Insulin sensitizer; Lifespan; Longevity;
Metformin; ageing.

Copyright (c) 2017 Elsevier B.V. All rights reserved.

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  * Aging / drug effects*
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  * Metformin / pharmacology
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  * Metformin / therapeutic use*
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  * Neoplasms / metabolism
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