https://www.sciencedirect.com/science/article/pii/S0955286319302554 JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. [1613170966] Skip to main content Skip to article Elsevier logo * Journals & Books * * RegisterSign in Sign inRegister * Journals & Books * Help Download PDFDownload [ ]Advanced Elsevier The Journal of Nutritional Biochemistry Volume 72, October 2019, 108217 The Journal of Nutritional Biochemistry Research Article A diet of U.S. military food rations alters gut microbiota composition and does not increase intestinal permeability Author links open overlay panelJ. PhilipKarl^aNicholes J.Armstrong^a Holly L.McClung^aRobert A.Player^bJennifer C.Rood^cKennethRacicot^d Jason W.Soares^eScott J.Montain^a Show more Share Cite https://doi.org/10.1016/j.jnutbio.2019.108217Get rights and content Under a Creative Commons license open access Abstract Interactions between gut microbes and dietary components modulate intestinal permeability (IP) and inflammation. Recent studies have reported altered fecal microbiota composition together with increased IP and inflammation in individuals consuming military food rations in austere environments, but could not isolate effects of the diet from environmental factors. To determine how the U.S. Meal, Ready-to-Eat food ration affects fecal microbiota composition, IP and inflammation, 60 adults (95% male,18-61 years) were randomized to consume their usual ad libitum diet for 31 days (CON) or a strictly controlled Meal, Ready-to-Eat-only diet for 21 days followed by their usual diet for 10 days (MRE). In both groups, fecal microbiota composition was measured before, during (INT, days 1-21) and after the intervention period. IP and inflammation [high-sensitivity C-reactive protein (hsCRP)] were measured on days 0, 10, 21 and 31. Longitudinal changes in fecal microbiota composition differed between groups (P=.005), and fecal samples collected from MRE during INT were identified with 88% accuracy using random forest models. The genera making the strongest contribution to that prediction accuracy included multiple lactic acid bacteria (Lactobacillus, Lactococcus, Leuconostoc), which demonstrated lower relative abundance in MRE, and several genera known to dominate the ileal microbiota (Streptococcus, Veillonella, Clostridium), the latter two demonstrating higher relative abundance in MRE. IP and hsCRP were both lower (34% and 41%, respectively) in MRE relative to CON on day 21 (P<.05) but did not differ otherwise. Findings demonstrate that a Meal, Ready-to-Eat ration diet alters fecal microbiota composition and does not increase IP or inflammation. * Previous article in issue * Next article in issue Keywords Gut microbiome Nutrition Gastrointestinal function Intestinal barrier Gut health 16S sequencing Recommended articlesCiting articles (0) ^ Funding: This work was supported by the Military Operational Medicine Research Program, US Army Medical Research and Materiel Command, which did not have any role in the design and conduct of the study, or in the analysis and interpretation of study results. View Abstract Published by Elsevier Inc. Recommended articles No articles found. Citing articles Article Metrics View article metrics Elsevier logo * About ScienceDirect * Remote access * Shopping cart * Advertise * Contact and support * Terms and conditions * Privacy policy We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Copyright (c) 2021 Elsevier B.V. or its licensors or contributors. ScienceDirect (r) is a registered trademark of Elsevier B.V. ScienceDirect (r) is a registered trademark of Elsevier B.V.