https://phys.org/news/2021-01-cancer-precisely-urine-artificial-intelligence.html Phys.org Topics * Week's top * Latest news * Unread news * Subscribe [ ] Science X Account [ ] [ ] [*] Remember me Sign In Click here to sign in with or Forget Password? Not a member? Sign up Learn more * Nanotechnology * Physics * Earth * Astronomy & Space * Technology * Chemistry * Biology * Other Sciences * * share this! * 43 * 58 * Share * Email 1. Home 2. Nanotechnology 3. Bio & Medicine 1. Home 2. Nanotechnology 3. Nanomaterials * * * --------------------------------------------------------------------- January 21, 2021 Cancer can be precisely diagnosed using a urine test with artificial intelligence by National Research Council of Science & Technology Cancer can be precisely diagnosed using a urine test with artificial intelligence The set of sensing signals collected for each patient were then analyzed using ML to screen the patient for PCa. Seventy-six urine samples were measured three times, thereby generating 912 biomarker signals or 228 sets of sensing signals. We used RF and NN algorithms to analyze the multimarker signals. Both algorithms provided an increased accuracy, and the AUROC increased in size as the number of biomarkers was increased. Credit: Korea Institute of Science and Technology (KIST) Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pain. The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique for diagnosing prostate cancer from urine within only 20 minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor. As a noninvasive method, a diagnostic test using urine is convenient for patients and does not need invasive biopsy, thereby diagnosing cancer without side effects. However, as the concentration of cancer factors is low in urine, urine-based biosensors are only used for classifying risk groups rather than for precise diagnosis thus far. Dr. Lee's team at the KIST has been working toward developing a technique for diagnosing disease from urine with an electrical-signal-based ultrasensitive biosensor. An approach using a single cancer factor associated with a cancer diagnosis was limited in increasing the diagnostic accuracy to over 90%. However, to overcome this limitation, the team simultaneously used different kinds of cancer factors instead of using only one to enhance the diagnostic accuracy innovatively. The team developed an ultrasensitive semiconductor sensor system capable of simultaneously measuring trace amounts of four selected cancer factors in urine for diagnosing prostate cancer. They trained AI by using the correlation between the four cancer factors, which were obtained from the developed sensor. The trained AI algorithm was then used to identify those with prostate cancer by analyzing complex patterns of the detected signals. The diagnosis of prostate cancer by utilizing the AI analysis successfully detected 76 urinary samples with almost 100 percent accuracy. "For patients who need surgery and/or treatments, cancer will be diagnosed with high accuracy by using urine to minimize unnecessary biopsy and treatments, which can dramatically reduce medical costs and medical staff's fatigue," Professor Jeong at Asan Medical Center said. "This research developed a smart biosensor that can rapidly diagnose prostate cancer with almost 100 percent accuracy only through a urine test, and it can be further used in the precise diagnoses of other cancers via a urine test," Dr. Lee at the KIST said. --------------------------------------------------------------------- Explore further Quit smoking, your bladder will thank you --------------------------------------------------------------------- More information: Hojun Kim et al, Noninvasive Precision Screening of Prostate Cancer by Urinary Multimarker Sensor and Artificial Intelligence Analysis, ACS Nano (2020). DOI: 10.1021/acsnano.0c06946 Journal information: ACS Nano Provided by National Research Council of Science & Technology Citation: Cancer can be precisely diagnosed using a urine test with artificial intelligence (2021, January 21) retrieved 21 January 2021 from https://phys.org/news/ 2021-01-cancer-precisely-urine-artificial-intelligence.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. 103 shares * Facebook * Twitter * Email Feedback to editors * Featured * Last Comments * Popular Gigantic dinosaur unearthed in Argentina could be largest land animal ever 8 hours ago 0 3-D printing highly stretchable hydrogel with diverse UV curable polymers Jan 20, 2021 0 Physicist proposes human-populated mega-satellite orbiting Ceres Jan 20, 2021 22 Fornax A galaxy investigated with AstroSat Jan 20, 2021 0 A realistic model of the ITER tokamak magnetic fusion device Jan 19, 2021 19 --------------------------------------------------------------------- [gif] Bringing atoms to a standstill: Researchers miniaturize laser cooling 1 hour ago [gif] Advances in modeling and sensors can help farmers and insurers manage risk 1 hour ago [gif] Squeezing a rock-star material could make it stable enough for solar cells 1 hour ago [gif] Nature's decline risks our quality of life 1 hour ago [gif] Snake sex chromosomes say less about sex and more about survival 2 hours ago [gif] Small electric fields can play decisive role in formation of diamond 2 hours ago [gif] Scientists discover how the potentially oldest coral reefs in the Mediterranean developed 2 hours ago --------------------------------------------------------------------- Relevant PhysicsForums posts Vaccines and Immune Response 4 hours ago ECMO for Deep Sea Scuba diving? 6 hours ago Calculate the R0 value from basic infection Data 23 hours ago Freezing temperature of vaccines Jan 20, 2021 SARS-CoV-2 Mutations Jan 20, 2021 Which COVID vaccines have adjuvants? Jan 19, 2021 More from Biology and Medical --------------------------------------------------------------------- * Related Stories [gif] Quit smoking, your bladder will thank you Nov 26, 2020 [gif] Should men be concerned about prostate cancer? Nov 19, 2020 [gif] Study: Biomarker in urine may offer noninvasive detection of prostate cancer Oct 02, 2019 [gif] Urine test could reduce unnecessary prostate cancer biopsies Mar 10, 2020 [gif] Urine-based test improves on PSA for detecting prostate cancer May 18, 2015 [gif] Researchers announce progress in developing an accurate, noninvasive urine test for prostate cancer Feb 28, 2020 * Recommended for you [gif] Researchers develop new graphene nanochannel water filters 4 hours ago [gif] Taking sieving lessons from nature 8 hours ago [gif] Drug-delivery microcapsules tagged with zirconium-89 can be tracked by PET imaging 8 hours ago [gif] Tiny structures generate powerful beams for enhanced optical imaging Jan 20, 2021 [gif] Gold nanoparticles more stable by putting rings on them Jan 20, 2021 [gif] Multidimensional coherent spectroscopy reveals triplet state coherences in cesium lead-halide perovskite nanocrystals Jan 19, 2021 User comments What do you think about this particular story? Your feedback will go directly to Science X editors. [ ] [ ] [ ] [ ] [ ] Your message to the editors [ ] Your email (only if you want to be contacted back) [ ] Send Feedback Thank you for taking your time to send in your valued opinion to Science X editors. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. Your opinions are important to us. We do not guarantee individual replies due to extremely high volume of correspondence. E-mail the story Cancer can be precisely diagnosed using a urine test with artificial intelligence Your friend's email [ ] Your email [ ] [ ] I would like to subscribe to Science X Newsletter. Learn more Your name [ ] Note Your email address is used only to let the recipient know who sent the email. Neither your address nor the recipient's address will be used for any other purpose. The information you enter will appear in your e-mail message and is not retained by Phys.org in any form. [ ] [ ] [ ] [ ] [ ] [ ] [ ] Your message [ ] Send Newsletter sign up Get weekly and/or daily updates delivered to your inbox. You can unsubscribe at any time and we'll never share your details to third parties. [ ] Subscribe More information Privacy policy Medical Xpress Medical Xpress Medical research advances and health news Tech Xplore Tech Xplore The latest engineering, electronics and technology advances Science X Science X The most comprehensive sci-tech news coverage on the web Newsletters [ ] Subscribe Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox Follow us * * * * * Top * Home * Search * Mobile version * Help * FAQ * About * Contact * Science X Account * Sponsored Account * Archive * News wire * Android app * iOS app * RSS feeds * Push notification (c) Phys.org 2003 - 2021 powered by Science X Network Privacy policy Terms of use Your Privacy This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. By using our site, you acknowledge that you have read and understand our Privacy Policy and Terms of Use. Ok More Information E-mail newsletter [ ] Subscribe Follow us * * * * It appears that you are currently using Ad Blocking software. What are the consequences? x Quantcast