INDEX

A-amino-acids, 61
Aborigines, gout unknown among, 2
Abscess formation in peri-tophal tissues, 234
skin resembling, in acute gout, 212
“Accessory food factors” in diet of gouty, 339
Adenase, 100, 101
Adenine, 73, 75, 77, 98
Aetius’s views on gout, 6
Age factor in gout, 40
influence of, on diet, in acute stage of gout, 333
Agotan in treatment of acute gout, 379
Aix massage baths, 427
Alanine, uric acid excretion augmented by, 89
Albuminuria, diet in, 358
Alcohol and gout, 48
hypersensitiveness of gouty to, 365
in febrile stage of sthenic gout, 333
in gout, 361
in subjects of gouty glycosuria, 237
modus operandi of, in induction of gout, 49
plus overeating, cause of gout, 49
Alcoholism, chronic, purin metabolism in, 115
Alexander of Tralles’s views on gout, 5
Alimentary canal, condition of, and gout, 174
disorders, effects of radio-active waters on, 439
tract, functional derangements of, in diagnosis of articular gout, 249
X-ray examination of, in treatment of gout, 336
Alkalies in inter-paroxysmal periods of gout, 392
in treatment of acute gout, 383
in treatment of chronic gout, 399
Alkaline waters, simple, spas for, 441
Alkapton in urine, 59
Alkaptonuria, 69
Allantoin, 104
Alternatives in treatment of chronic gout, 401
Alveolus, senile atrophy of, 329
Amberg and Jones’ scheme of formation of uric acid, 104
America, United States of, gout in, 47
Amino-acetic-acid, 64
Amino-acids and dicarboxylic amino-acids, 89
deaminisation of, 62, 63
fate of, 62
in portal blood, 62
in relation to gout, 64
Amino-purins, as source of uric acid, 84
Amylaceous dyspepsia, diet in, 351, 352
Anacritical stage of depression, 211
Anæmia in cases of long-standing gout, treatment of, 406
retention capacity of tissues for uric acid in, 158
Anatomical alterations in articulations, 54
Anglo-Saxon period, prevalence of gout in, 2
Animal cells, nucleic acid derived from, 98
Animals, various, uric acid blood content of, 135
Ankylosis in chronic gout, 287
Anodyne preparations in treatment of acute gout, 384, 385
Anodynes in acute gout, 383
Antiquity of gout, 1
Anuria, hysteria in, 126
Aponeuroses, gouty polyarthritis in, 214
Appendicitis, septic foci of, 184
Appendix-dyspepsia, 184
Arab physicians’ views on gout, 6
Aretæus the Cappadocian’s views on gout, 4, 5
Arterio-sclerosis, associated with gout, 245
blood-content in, 127
spa treatment of, 451
Arthralgia, fleeting, 193
Arthritic attacks, tophi formation preceding, 164
iritis, 315
Arthritides, specific infective, and gout, analogies between, 194
Arthritis deformans, cleavage into two types, 18
differentiation of, from chronic gout, 16
rheumatoid, and osteoarthritis, 20
Arthritis, gonococcal, acute, differential diagnosis from acute gouty polyarthritis, 270
from gout, 259
of tarsus and metatarsus, differential diagnosis from gout, 263
gouty, 39
definition of, 20
frequency of tophi in, 255
relation to local foci of infection, 185
Greek designation, 3
hæmophilia, differential diagnosis from chronic gout, 285
infective, of undifferentiated type, differential diagnosis from acute polyarticular gout, 272
skiagraphy in differential diagnosis of, 290
non-gouty, hyper-uricæmia in, 140
rheumatoid, 17
differential diagnosis from chronic gout, 284
local character of joint swellings, 284
or atrophic, acute, differential diagnosis from acute gouty polyarthritis, 272
skiagraphy in differential diagnosis of, 291
syphilitic, differential diagnosis from chronic articular gout, 277
secondary, differential diagnosis from acute gouty polyarthritis, 271
tophi in relation to, 254
Arthropathies, nerve, differential diagnosis from chronic gout, 284
Articular gout, chronic, medicinal and other modes of therapy, 397
etiological diagnosis, 247
Articular lesions in chronic gout, distribution of, 226
Asphyxias, local, of hands, in gout, 45
Atophan, effect of, on exogenous purins, 110
on uric acid excretion, 119
indicated when gout attack imminent, 395
in treatment of acute gout, 379
in treatment of chronic gout, 403
Auricular tophi, 202
Auto-intoxication theory of gout, 182
Auto-toxæmia theory of gout, 182
Avicenna’s views on gout, 6
Bacillus coli communis as causative agent in gout, 175
Bacterial flora, intestinal, modifications in, 182
Bacteriological examination in diagnosis of articular gout, 251
Baillon’s dissociation of rheumatism from gout, 15
Banting method in reduction of obesity, 357
Barclay’s theories of ætiology of gout, 23
Bath as residence for gouty, 419
Bath waters, Sir W. Ramsay’s analysis of, 435
Baths in treatment of gout, method of application, 427
Beaumont, W. M., ocular disease in the gouty, 308
Beauvais’s work on gout, 17
Beer as beverage in gout, 362
Benzoates in treatment of chronic gout, 401
Berkart’s theory of ætiology of gout, 27
views on gout, 56
Beverages in gout, 359
Bismuth carbonate in inter-paroxysmal periods of gout, 392
Biurate of soda in gouty tophi, 151
Blisters in treatment of acute gout, 386
Blood, changes in, in acute gout, 210
in chronic articular gout, 226
in gouty polyarthritis, 216
content in gout, 189
count in acute gout, 211
Blood, examination of, in diagnosis of articular gout, 251
Blood, human, relationship between amounts of uric acid, urea and non-protein nitrogen in, 122
in chronic interstitial nephritis, urates in, 120
in disease, uric acid of, 137
portal, amino-acids in, 62
routine examination of, in diagnosis of articular gout, 249
uric acid as normal constituent of, 135
uric acid content of, and gout, relation between, 143
effect of diet upon, 141
effect of exogenous purins on, 137
estimation of sources of fallacy, 145
in gout, 133, 139
uric acid in, 24, 34, 78
discovery of, 21
Folin and Denis’s method of determination, 133
forms of, 145
Gudzent and Schade’s theories, 79
non-protein nitrogen and urea nitrogen in (table), 136
variations in uric acid content independently of diet, 142
Bodily conformation, and gout, 44
Boils, gout following, 53, 178
Bone, conditions of, revealed by skiagraphy, in diagnosis of gout, 286
Bones, changes in, in gout, 53
focal areas of rarefaction in, revealed by skiagraphy, 286, 287
Brandy in gout, 371
Bruce’s modes, 286
Bunion, inflamed, differential diagnosis from gout, 261
Burian and Schur’s researches on sources of uric acid, 83
Bursæ, involved in gout, 195
tophi in, 233
Bursitis, olecranon, gouty, 215
post-calcaneal, in referred pain in heel, 265
Cælius Aurelianus’s views on gout, 5
Caffeine, 85
Calcium carbonate in inter-paroxysmal periods of gout, 392
salts in gouty tophi, 151
Calculus, urinary, 29
Carbohydrates in diet of gouty, 347
Carbuncles, gout following, 53, 178
Cartilage, morbid changes in, 53
uratic deposits in, 52, 153
in nephritis, 128
Cataphoresis in treatment of chronic articular gout, 407
Cell protoplasm, chemistry of, 176
Celsus’s views on gout, 4
“Chalk-stones,” 150
Chalybeate waters, spas for, 442
Champagne in gout, 368
Charcot’s discovery of nerve arthropathies, 18
joint, differential diagnosis from chronic articular gout, 277
Chemistry of uric acid and purin bodies, 75
Chilblains confused with early stages of tophi formation, 164
Chirargra, Greek designation, 3
Cholecystitis, 184
Cider as beverage in gout, 363
Claret in gout, 369
Climate and gout, 45
and residence in treatment of gout, 418
Climato-therapy in gout, 418
Clothing, importance of, 421
Cocoa as beverage in gout, 361
Coffee as beverage in gout, 361
Colchicine in treatment of acute gout, 378
Colchicum in acute gout, 192, 374, 375, 378
contra-indicated, alkalies as substitute, 383
method of administration, 376
preparations and dosage of, 376
used by Aetius, 6
Colitis, mucous, initial manifestations of gout, 175
Colloids in gouty tophi, 152
Collosol iodine in treatment of chronic gout, 402
Colorimetric method of determining uric acid in blood, 133
Colour reaction test in blood analysis, 133
Condiments in diet of gouty, 350
Constipation, effect in gout, 337
in acute gout, treatment of, 373
in chronic gout, treatment of, 400
in inter-paroxysmal periods of gout, treatment of, 393
Constitutional disturbance in gout, 188
influences in formation of tophi, 161
Corpora cavernosa of penis, tophi in, 235
Cramps in acute gout, 210
Cream, effect of, on uric acid output, 348
Creatine, 63, 67
in urine of children, 68
Creatinine, 61, 63, 67, 68
in blood in gout and nephritis (table), 121
Crystalline deposits in synovial fluid, 54
Crystalloids in gouty tophi, 152
Cytosine, 98
Cullen’s differentiation of varieties of rheumatism, 16
theory of ætiology of gout, 21
Cutaneous disorders in gout, 240
gravel, 203
Cuticule, desquamation of, typical of gout, 191
Cystin in urine, 59
Cystinuria, 69
Cystoid degeneration in gout, 56
Deaminisation of amino-acids, 62, 63
Deficiency diseases and accessory food factors, 340
Degeneration, theories of, 25, 27
Desquamation in acute gout, 212
Diabetes, glycosuria and, 60
Dicarboxylic amino-acids, 89
Diet, effect of, on blood content of uric acid, 141
Diet on excretion of uric acid, 83
Diet in acute paroxysms of gout, 332
in albuminuria, 358
in amylaceous dyspepsia, 351, 352
in chronic gout, 334
in glycosuria, 357
in hyperchlorhydria, 353
in hyperuricæmia, 354
in hypochlorhydria, 354
in inter-paroxysmal periods of gout, 391
in reduction of obesity, 357
in treatment of gout, 332
“accessory food factors,” 339
carbohydrates, 347
collaboration of clinician and bio-chemist, need for, 337
condiments, 350
fats, 347
fish, 346
fruits, 349
idiosyncrasies of, 343
physical examination necessary before, 336
proteins, 345
regulations of, 342
vegetables, 348
variations of blood content of uric acid independently of, 142
Dietaries, fixed, fallacy of, in treatment of gout, 335
Digestion, disturbances of, prevention of, in treatment of gout, 335
Digestive glands, rôle of, in uric acid excretion, 88
Diocletian, edict by, re gout, 5
Dislocations, signalising attack of gout, 53
Douches, 428
Dover’s powder, with aspirin and phenacetin, in treatment of acute gout, 383
Drink and gout, 48
“Drug dyspepsia,” 391
Drugs influencing excretion of endogenous uric acid, 96
Duckworth’s classification of arthritic type of gout, 36
theory of ætiology of gout, 33
Dyschezia and gout, 337
Dysenteric arthritis, differential diagnosis from acute gouty polyarthritis, 272
Dysentery, complicated by arthritis and myalgias, 194
Dyspepsia, amylaceous, diet in, 351, 352
atonic, muriated waters in treatment of, 444
chronic, gout associated with, 178
“drug,” 391
gouty, no specific form of, 350
intestinal, preceding gout, 182
mineral waters in treatment of, 443
spas in treatment of, 442
Dyspeptic symptoms of acute localised gout, 201
Ear, pricking or tenderness in, 203
tophus in, 202
Ears, tophi in, antedating articular outbreaks, 203
Ebstein and Sprague’s analysis of tophi, 150
Ebstein’s theory of ætiology of gout, 25
Ecchymoses, local, in acute gout, 212
Eczema, gouty, spa treatment of, 451
treatment of, 416
in gout, 241
Egypt, osteoarthritis in, in ancient times, 1
Endemic areas of gout, 46
Endogenous purins, 87
origin of, 83
source of, 88
uric acid excretion, 91
factors influencing, 93
increased by purin-free proteid food, 89
pathological states influencing, 94
periodic variations of, 94
physiological conditions, 93
Environment in gout, 40
Enzymes, distribution of, 99
in intestinal juices and wall, 100
Epistaxis, gout following, 178
Epithelial cells, nucleus in gouty tophi, 151
Erysipelas, gouty arthritis simulating, 215
Erythromelalgia, differential diagnosis from gout, 266
Etiological diagnosis of articular gout, 247
Exercise in gout, importance of, 421
relation of, to gout, 337
Exogenous origin of purins, 83
purins as source of uric acid, 84
uric acid excretion, 85
Exudative diathesis, 116
Eye, deposition of urates in, 309
gout in, evidence of, 309
gouty diathesis in regard to, 310
Eyelids, uratic deposits in, 235
Fæces, examination of, in diagnosis of articular gout, 250
in treatment of gout, 337
Fasciæ, involved in gout, 195
“Fat soluble A,” 340
Fats in diet of gouty, 347
Feet, incidence of tophi in, 162
plantar surface of, tophi in, 235
Fibrosis, interstitial, chronic, 186
of visceral organs in gout, tendency to, 186
Fibrositis associated with acute articular gout, 195
associated with gout, treatment of, 411
gouty, acute brachial, treatment of, 412
incidence of gouty stigmata in types of, 221, 222
muscular, in gouty, massage in, 423
spa treatment of, 450
Fingers, deformed, in chronic gout, 230
pulps of, tophi in, 235
Fischer’s researches on protein molecule, 61
Fish in diet of gouty, 346
Flatfoot, pains in, differential diagnosis from gout, 263
“Flying gout,” 193
Foci of infection in gouty, 53
local, in gout, 177
Foci, relation to gouty synovitis and arthritis, 185
Folin and Denis’s method of determination of uric acid in blood, 133
researches into urea formation, 63
Food, cooking of, in diet of gouty, 344
influence on gout, 48
Foods, various, exogenous urinary purin in, amount of, 85
Foot deformities, static, differential diagnosis from gout, 261
“Fot-adl,” Anglo-Saxon name for gout, 3
Fractures, signalising attack of gout, 53
Fruits in diet of gouty, 349
Function, gout a disorder of, 200
Functional disturbances in gout, 201
Galen’s views on gout, 2, 4
Gall-stones, gout associated with, 184
Gall-bladder dyspepsia, 184
Garrod’s discovery of uric acid in blood of gouty persons, 21
pathogeny of gout, growing scepticism as to, 32
theory of ætiology of gout, 22
views on gout in the eye, 320
Gastralgias in gouty, 351
Gastric catarrh, chronic, gout associated with, 351
chronic, mineral waters suitable for, 445
glands, diseased conditions of, and gout, 173
insufficiency, muriated waters in treatment of, 444
Gastro-intestinal asepsis, importance of, in gout, 332
derangements in acute paroxysms of gout, 333
disorders and gout, 180
attributed to gout, 299-302
chronic, spas in treatment of, 442
mineral waters in treatment of, 443
tract, derangement of, cause of gout, 170
Genito-urinary passages, infection of, examination for, in diagnosis of articular gout, 249
tract, examination of, in treatment of gout, 331
Geographical distribution of gout, 45-48
Gin in gout, 371
Glandular affections in gouty subjects, 179
Glaucoma, gout and, 324
Glycocine and urea, interaction between, 84
Glycocoll, rôle of, 64
theory of gout, 65
uric acid excretion augmented by, 89
Glycosuria and diabetes, 60
associated with gout, treatment of, 414
diet in, 357
examination for, in treatment of gout, 337
gout and, co-existence of, 185
gout in relation to, 236
“gouty,” 182
spa treatment of, 449
Glyoxylic acid in gouty urine, 65
Gonococcal arthritis of tarsus and metatarsus, differential diagnosis from gout, 263
infection, articular involvement, with muscular and nervous lesions, 194
differential diagnosis from gout, 259
exclusion of, in diagnosis of articular gout, 248
Gore, Ringrose, theory of pathology of gout, 173
Gout, acute, colchicum in, 375
definitely paroxysmal, 191
general phenomena of, 210
ionisation in treatment of, 387
local phenomena, 211
localised, clinical account, 200
dyspeptic symptoms of, 201
premonitory articular pains, 204
prodromal symptoms, 200
locality of, 208
medicinal treatment of, 372
onset of, 207
pain in, 208
paroxysm of, analysis of, 188
diet in, 332
symptoms of, 205
uric acid variations in, 117
surgical methods considered, 388
treatment of, alternative remedies in, 381
local measures, 384
uric acid excretion in, 117, 211
uric acid variations in, 108, 117
ætiology of, histogenous theories of, 23
nervous theories, 31
summary of, 44
theory of antecedent structural changes, 25
age factor in, 40
alcohol in, 361
amino-acids in relation to, 64
and fibrositis, incidence of, 221
and granular kidney, clinical associations of, 130
and immunity, early fallacies regarding, 10
and nephritis, 242
and other diseases, affinities between, 236
and rheumatoid arthritis, resemblance between, 113
and specific infective arthritides, analogies between, 194
antiquity of, 1
arterio-sclerosis associated with, 245
articular, acute, differential diagnosis, 259
localised, clinical diagnosis, 258
chronic, 225
alkalies in treatment of, 399
blood changes in, 226
clinical diagnosis of, 275
distribution of, 226
local measures in, 407
medicinal and other modes of therapy, 397
progress of disease, 228
surgical treatment, 409
classification of, author’s division, 38
clinical diagnosis of, 252
etiological diagnosis, 247
manifestations of, 195
as an infection, 177
auto-intoxication theory, summary, 182
beverages in, 359
blood content in, 127
uric acid and, relation between, 143
choice of spa in treatment of, 440
chronic, ankylosis in, 287
confusion with chronic villous synovitis, 279
diet in, 334
differentiation of, from arthritis deformans, 16
joint deformities of, 229
of oligo-articular distribution, 278
polyarticular, clinical features, 282
polyarticular, differential diagnosis, 282
tardy dissociation of, from chronic rheumatism, 15
uric acid variations in, 109
classification of, 35, 36
climate and residence in treatment of, 418
climato-therapy in, 418
clinical account of, 200
clothing and, 421
collateral phenomena of, 219
constipation and, 337
cutaneous disorders in, 240
definition of, 35
author’s, 36
derangement of gastro-intestinal tract as cause of, 171
elimination of infective arthritides from domain of, 19
endemic areas in, 46
etiology of, 39
evolution and life history of, 193
excretion in, anomalies of, 112
exercise in, importance of, 421
false, ocular symptoms, 322
glycocoll theory of, 65
Greek physicians’ views of pathology of, 3
growing infrequency and attenuation of, 12
guanine, in swine, 100
heredity and, 41
hydrotherapy, general, in treatment of, 424
local, in treatment of, methods of, 428
hyperpyræmia in ætiology of, 30
in big toe, differential diagnosis, 259
infantile, 116, 305
infective theory of, rise of, 171
summary, 182, 183
inflammatory phenomena in, cause of, 165
initial attacks usually monarticular, 207
initial outbreaks of, anomalous sites for, 267
sites of, 37
in relation to glycosuria, 236
in relation to phlebitis, 239
in the heel, 264
in the instep, 262
in the sole, 265
inter-paroxysmal period, treatment in, prophylactic measures, 389
introduction of word, 6
irregular, 293
conclusions regarding, 304
isolation of acute articular rheumatism from, 15
lead workers predisposed to, 50
leanness in, 337
leucocytosis in, 172, 189
life history of, 193
local foci of infection, 177
treatment of, radical, 327
local syncopes and asphyxias of hands in, 45
long-continued, favouring onset of pre-senilism, 398
lumbago associated with, 221
massage, general, in treatment, 423
metabolic phenomena correlated with postulated infective element, 195
mineral springs in treatment of, 431
monarticular, chronic, differential diagnosis of, 276, 277
morbid anatomy of, 39, 53
morbid conditions associated with, treatment of, 411
obesity in, reduction of, 356
ocular disease in, 308
frequency a factor in diagnosis, 316
onset of, symptoms, 188
organic predisposition to, 43
other conditions classified as, in early times, 12
pathogenesis of, earlier theories of, 21
pedigree of, 14
periodicity of, 191
phenomena of, detailed account of, 207
predisposing causes of, summary of, 52
prevalence of, in Anglo-Saxon period, 2
prognosis in, 244
renal theory of, 117
restriction of, by elimination of other disorders, 19
retarded purin elimination in, 118
retention capacity of tissues for uric acid in, 158
retrocedent, 39, 296
irregular manifestations of, 299
sex incidence of, 41
skiagraphy in diagnosis of, 286
specific organism suggested, 175
sthenic, febrile stage of, alcohol and, 333
structural changes, 54
sub-infection theory, summary, 182, 183
subjective phenomena of, in relation to blood content and excretion of uric acid, radium emanations and, 438
“the honour of,” 8
theory of hepatic inadequacy, 28
tophaceous, 39
treatment of, 327
diet in, 332, 342
fallacy of fixed dietaries, 335
gastro-intestinal asepsis in, 332
hyperæmia, 429
physical examination necessary before dieting, 336
prevention of digestive disturbances, 335
uratic deposits in, 54
differentiation from nephritis, 129
localisation of, 153
uratosis in relation to, 149
urea excretion in, 66
uric acid content of blood in, 139
uric acid excretion in, 108
anomalies in, 117
uric acid in relation to, 107
uric acid theory of, 21
uric acid, urea and creatine in blood in (table), 211
uricæmia in, 125, 133
not cause, but result, of, 148
variations in excretion in, diagnosis of, 60
Gouty arthritis, definition of, 20
phlebitis, 240
polyarthritis, acute, 214
stigmata in types of fibrositis, 222
“Gravel, cutaneous,” 203
immunity from, 29
Greek physicians, terms used for forms of gout, 3
views of pathology of gout, 3
Guaiacum in treatment of chronic gout, 403
resin, effects on urine, 405
Guanase, 100, 101
Guanine, 73, 75, 77, 98
gout in swine, 100
Gudzent and Schade’s theories of uric acid in blood, 79
Gummata, peri-bursal, 281
peri-synovial, 281
Gums, recession of, early, 45
Hæmatemesis, gout following, 178
Hæmo-analysis, 147
Hæmophilic arthritis, differential diagnosis from chronic gout, 285
Hæmorrhage, retinal, and gout, 322
Hair, premature whitening of, 45
Hallux rigidus, differential diagnosis from gout, 262
valgus with inflamed bunion, differential diagnosis from gout, 261
Haly Abbas’s views on gout, 6
Hand, gouty polyarthritis in, 214
Hands, deformed, in chronic gout, 230
incidence of tophi in, 162
local syncopes and asphyxias in gout, 45
palms of, tophi in, 235
Hare’s theory of ætiology of gout, 30
Heart affections in gouty subjects, 302
Heberden’s differentiation of rheumatoid arthritis from gout, 17
nodes, 41, 283
Heel, gout in, 264
referred pain in, differential diagnosis in, 264
local sources of fallacy, 265
Hepatic derangement in acute paroxysms of gout, 333
inadequacy theory of ætiology of gout, 28
Heredity in gout, 8, 28, 40, 41, 214
Herpes in acute gout, 241
Hexose group in vegetable nucleic acids, 98
Hippocrates, aphorisms of, on gout, 4
Histogenous theories of ætiology of gout, 23
Historical survey, 1
Horbaczewski’s experiments on uric acid, 73
Hot-air baths, 429
contra-indications to use of, 429
Hutchinson on gout and rheumatism, 15
Hydrarthrosis, bilateral, 281
in chronic articular gout, 278
Hydrochloric acid, secretion of, and gout, 173
strong or fuming, in inter-paroxysmal periods of gout, 393
variations in, and gout, 181
Hydro-therapy, general, in treatment of gout, 424
in acute gout, 385
in treatment of gout, contra-indications and untoward complications, 425
methods of application, 427
prophylactic measures, 424
local, in treatment of gout, 428
Hyperacidity due to organic acids, 351
in inter-paroxysmal periods of gout, 393
Hyperæmia, treatment of gout by, 429
Hyperchlorhydria, 181, 351
associated with gout, treatment of, 415
complicating gout, salt in diet contra-indicated, 350
diet in, 353
mineral waters suitable in treatment of, 446
Hyperpyræmia in ætiology of gout, 30
Hyperuricæmia, diet in, 354
in gout, 140
in non-gouty arthritis, 140
ocular symptoms in, 321
Hypochlorhydria, 351
diet in, 354
Hypoxanthine, 73, 75, 77
Indigestion, intestinal, in gouty subjects, 181
Infantile gout, 116, 305
Infection in gout, local foci of, 177
examination for in diagnosis of articular gout, 248
theory of gout, 182, 183
Infections, differential diagnosis from acute localised articular gout, 259
specific, arthritic muscular and nerve lesions associated with, 195
diagnosis of, 19
Infective element in gout, correlated with metabolic phenomena, 195
Inflammation and tophi formation, 164
gouty, pus formation and, 191
Inflammatory phenomena in gout, cause of, 165
Influenzal arthritis, differential diagnosis from acute gouty polyarthritis, 272
Immunity conferred by gout, early fallacies regarding, 10
Inosinic acid, 93
Instep, gout in the, 262
Intestinal canal, source of microbe or toxin in gout, 181
derangements, mineral waters suitable in treatment of, 448
dyspepsia preceding gout, 182
indigestion in gouty subjects, 181
irrigation with radio-active waters, 439
juices and wall, enzymes in, 100
Iodides in treatment of chronic gout, 401
value of, in renal and vascular changes, 403
Iodine-albumen compounds in treatment of chronic gout, 402
Iodo-glidine in treatment of chronic gout, 402
Iodo-protein in treatment of chronic gout, 402
Ionisation in treatment of acute gout, 387
in treatment of chronic articular gout, 407
Iritis, “arthritic,” 315
diseases commonly associated with, 313
gouty, “not” a clinical entity, 316
in gout, 308
relative incidence of, 313
Irregular gout, 293
Isomeric forms of uric acid, 81
Isomers of purins, 81
of pyrimidins, 81
Jaw, formation of, 45
Jaws, radiographs of, in treatment of gout, 328
Joint cartilage, murexide reaction in, 153
deformities of, chronic gout, 229
Joints, diaphyses of, cystic changes in, 56
rheumatism of, 14
stiffness of, after acute attacks of gout, 212
swellings, local character of, in osteo-arthritis, 283
local character of, in rheumatoid arthritis, 284
tophi in, 233
Juices, gastric and intestinal, gout and, 173
Kidney and kidneys, capacity of for eliminating uric acid, 125
condition of, effect in blood content of uric acid, 138
disease of, granular, and gout, clinical, association, 130
joint examination in, results of, 129
disease of, and gout, 242
functionally deficient in late stage of gout, 119
functional disorders of, 27, 28
functional efficiency of, tests for, 338
gouty, histological changes in, 127
guanase in, 100
uric acid elimination in, 119
Knee, gouty polyarthritis in, 214
site of primary attack of gout, 267
Kossel’s discovery of purin bases, 73
Labile protein, 59
Latham’s theory of hepatic origin of gout, 29
“Lead gout,” 50
Lead, elimination by iodides, 403
poisoning, blood content in, 122, 123, 127
ocular symptoms in, 321
purin metabolism in, 115
workers, predisposed to gout, 50
Leanness in gout, 337
Lehmann’s analysis of tophi, 150
Leucocytosis, 24, 27
during acute attacks of gout, 172
in gout, 189
in gouty polyarthritis, 216
relation to uric acid excretion, 95
Leucopenia, 96
in gout, 189
Leukæmia, blood content in, 122, 123
ocular symptoms in, 321
uric acid in urine in, 95
Levy’s (Magnus) researches on gout, 107
Limbs, integument of tophi in, 235
Lime salts, focal absorption of, in bones, 288
Liniments in treatment of acute gout, 386
Literature of various periods, references to gout in, 3
Lithæmia, 294
tendency to, 28, 33
Lithiasis, 29
Lithium salts in treatment of chronic gout, 400
Lithuria, 29
Liveing’s theory of ætiology of gout, 31
Liver, diseases of, amino-acids in, 59
disorders of, functional, mineral waters suitable in treatment of, 447
enzymes in, 99
functional efficiency of, tests for, 338
glycogenic distension of, 31
guanase in, 100
main centre of production of urea, 63
Living, style of, effect on incidence of gout, 2
Locality, factor in gout, 45
incidence of, in acute gout, 208
Lucian of Saramosta’s views on gout, 4
Lumbago, associated with gout, 221
treatment of, 411
Lung, guanase in, 100
Lymph spaces, purins in, 146
stream, sodium ions in, 146
Lymphangitis, co-existent with gout, 58
in gout, 190
Lymphatic gland, enlargement of, in gout, 190
Lymphatics, purins in, 146
Malt liquors in gout, 362
Marchand’s analysis of tophi, 150
Massage, general, in treatment of gout, 423
in after-treatment of acute gout, 385, 387
McCarrison’s views on effect of absence of vitamines on functional efficiency, 340
McClure and McCarty’s researches on bone conditions as revealed by skiagraphy, 288, 289
Meat, over-eating of, functional damage resulting from, 65
Meningococcal arthritis, differential diagnosis from acute gouty polyarthritis, 272
Menstruation, effect of, on incidence of gout, 41
Mental over-exertion and gout, 51
Metabolic phenomena of gout correlated with postulated infective element, 195
Metabolism, alterations in, 30
inborn errors of, 69
nuclein, 71
protein, 59, 61
Metastasis in relation to ocular gout, 314
gouty, 297
Metatarsalgia, differential diagnosis from gout, 262
Methyl-purins as source of uric acid, 85
Microbic theory of gout, 175
Miescher’s researches on spermatozoa, 72
on the nucleus, 71
Milk diet in acute paroxysms of gout, 332
Mineral springs, 431
waters as beverage in gout, 360
Monarticular gout, differential diagnosis of, 276, 277
Morphia, hypodermic injections of, in acute gout, 383
Mouth, examination of, in diagnosis of articular gout, 248
in treatment of gout, 328
local foci of infection, results of, 184
Murchison’s theory of ætiology of gout, 28
Murexide reaction in joint cartilage, 153
Muriated chloride waters, spas for, 441
sulphated waters, spas for, 442
Muscles, affections of, in gout, 195
voluntary, relation of creatinine to, 68
Muscular exercise, uric acid excretion increased by, 93
Myeloma, waste of albumoses in, 59
Nails, striated, fluted and brittle, 45
Nasal affections, radium emanations for, 438
disorders, gout and, 178
Naso-pharynx, examination of, in treatment of gout, 328
foci of infection, 53
Necrosis, local, in uratic deposition, 152
relationship to gout, 25
Nephritis, acute and chronic, blood content in, 127
chronic, spa treatment of, 452
complicating gouty polyarthritis, 219
early, blood content of uric acid, urea and creatine, similarity to gout, 120
gout and, 242
gouty, treatment of, 416
uratic deposits in, 128
differentiation from gout, 129
uric acid, urea and creatine in blood in (table), 121
uricæmia in, 120
uricæmia not peculiar to, 124
Nerve arthropathies, differential diagnosis from chronic gout, 284
Charcot’s discovery of, 18
Nervous phenomena of gout, 188, 304
system, effect of gout on, 219
theories of ætiology of gout, 31
Neuralgia, plantar, differential diagnosis from gout, 266
Neuritis, alcoholic peripheral, 238
glycosuric peripheral, 238
Neuro-lymphatismus, 116
Neuro-retinitis in the gouty, 324
Neurosis, gouty, 31
Neuroses, paroxysmal, of gout, 188
Nose, alæ of, tophi in, 235
Nuclease, 100
Nucleic acid, 72, 77
characteristic constituents of, 78
disruption of, 100
in body, 74
formation of uric acid from, 98
isolation of, 71
metabolism of, in gout, 69
molecules, 101
of animal origin, structural formula of, 99
physiological derivation of uric acid from, 73
uric acid a derivative of, 73
Nucleic-acidase, 100
Nuclein, discovery of, 72
metabolism, 71
chemistry of, 60
Nucleins, 77
phosphoric acid group in, 112
Nucleo-proteins, 77
Nucleosidases, 101
Nucleosides, 87, 100
Nucleotidase, 100
Nucleotides, 100
Numbness after acute attacks of gout, 212
Obesity and gout, 245
Ebstein’s views of affinity, 280
in gout, 337
reduction of, 356
Occupation and gout, 48
Occupations predisposing to gout, 50
Ocular disease in gout, 308
Œdema in acute gout, 212
in gouty conditions, 191
Olecranon bursa, involved in gout, 215
tophi in, 233, 235
Oligo-articular distribution of chronic gout, 278
Oral sepsis in gouty subjects, 179
radium emanations and, 438
treatment of, in gout, 330
Ord’s theory of ætiology of gout, 25
Osler’s views on gout, 36
Osteoarthritis, acute, differential diagnosis from gout, 261
and chronic articular gout, 275, 276
co-existing with gout, 19
differential diagnosis from chronic articular gout, 278
differential diagnosis from chronic gout, 283
in ancient civilisations, 1
local characters of joint swellings, 283
of hip, with auricular tophi, 226
skiagraphy in differential diagnosis of, 291
Overeating and gout, 48
plus alcohol, cause of gout, 49
Oxaluria associated with gout, treatment of, 413
examination for, in treatment of gout, 337
spa treatment of, 449
Oxidation of purin, products of, 77
Oxy-purins as source of uric acid, 84
formation of, 102
Pain and tophi formation, 164
in acute gout, 208
in auricular tophi, 233
referred, in heel, differential diagnosis of, 264
Pains, premonitory articular, in acute localised gout, 204
Painters, predisposed to gout, 50
Pancreas, enzymes in, 99
Pancreatic inefficiency, evidence of, in diagnosis of articular gout, 250
Pancretin, 392
Papain, 392
Parke’s theories of ætiology of gout, 23
Parotitis, acute, gout following, 53
in gout, 179
Patella, tophi in, 235
Pathological states influencing endogenous uric acid excretions, 94
Paulus Ægineta’s views on gout, 6
Pedigree of gout, 14
Pentosuria, 69
Peri-bursal gummata, 281
Perineum, uratic deposits in, 235
Periodic variations in excretion of endogenous uric acid, 94
Periodontitis, chronic, 329
Peri-synovial gummata, 281
Pes planus, differential diagnosis from gout, 263
Pharyngeal affections, radium emanations for, 438
Pharyngitis, acute and chronic, in gouty subjects, 179
acute, gout following, 53
Pharynx, examination of, in diagnosis of articular gout, 249
Phlebitis, gout in relation to, 239
gouty, treatment of, 415
in limb in articular gout, 190
spa treatment of, 450
treatment of gout and, 328
Phospho-nuclease, 102
Physical examination, necessity for, before dieting, in treatment of gout, 336
over-exertion and gout, 51
Physiognomy of the goutily disposed, 44
Pinna, small red swellings on, 204
Planchon’s views on gout, 6
Plantar neuralgia, differential diagnosis from gout, 266
Pleurodynia associated with gout, treatment of, 412
Plumbers, predisposed to gout, 50
Plumbism and gout, 60
purin metabolism in, 115
Pneumococcal arthritis, differential diagnosis from acute gouty polyarthritis, 272
Podagra, 12
Greek designation, 3
Polyarthritis, articular, acute, differential diagnosis of, 269, 270
gouty, acute, 214
clinical diagnosis of, 268
diet in, 334
blood changes in, 216
distribution of, 214
effect on nervous system, 219
simulating erysipelas, 215
non-gouty, uric acid blood content in, 141
Polyarticular distribution of gout, 214
Poly-nucleotides, 100
Port wine in gout, 364, 368
Portal blood, amino-acids in, 62
Post-critical stage of depression, 211
Potash compounds in treatment of chronic gout, 400
Potassium in gouty tophi, 151
Prescriptions for use in acute gout, 375, 377, 378, 379, 380, 386, 391
for use in chronic gout, 401, 405, 406
for use in inter-paroxysmal periods of gout, 391, 392, 393, 394
Pre-senilism, long-continued gout favouring, 398
Protamine, 72
Protein, amino-acids in, number of, 64
chemistry of, 60
labile, 59
metabolism, 59, 61
urine content of urea, etc., in, 59
tissue, 59
Proteins and their derivatives, 88
in diet of gouty, 345
Pulse quickened in gout, 189
Purgatives in treatment of acute gout, 374
Purin bases, toxicity of, discussed, 168
bodies, 34, 48, 63
chemistry of, 75
diet, uric acid excretion in, 86
“free” diet, 355
uric acid blood content in, 137
uric acid excretion in, 86
elimination, retarded, in gout, 118
metabolism, chemistry of, 60
in chronic alcoholism, 115
in other disorders, 113
in plumbism, 115
nuclease, 102
nucleus, arrangement of atoms, 76
oxidation of, products of, 77
scheme illustrating probable stages in passage through body, 101
synthesis in mammals, 97
unexcreted, fate of, 87
Purins, discovery of, 72
endogenous, 83, 87
source of, 88
exogenous, 83
as source of uric acid, 84
effect of atophan on, 110
effect on uric acid blood content, 137
isomers of, 81
of vegetable origin, 77
Pus formation, non-existence of, in gouty inflammation, 186, 191
Pyæmia, differential diagnosis from gout, 259
Pyæmic conditions confounded with gout, 191
Pyorrhœa alveolaris, and gout, 178
and treatment of gout, 329
exclusion of, in diagnosis of articular gout, 248
Pyrexia in acute gout, 210
in gout, 189
Pyrimidine bases, 77
Pyrimidins, isomers of, 81
Quadriurate in blood, 78, 79
Quinic acid in treatment of acute gout, 383
Quinine in treatment of acute gout, 383
Race incidence of gout, 45-48
Radio-active properties of thermal waters, 427
waters, physical properties of, 434
Radium emanation, increased excretion of uric acid through, 437
influence on uric acid metabolism, 436
physiological action of, 435
subjective phenomena of gout in relation to blood content and excretion of uric acid and, 438
therapeutic action and application, 438
Regular gout, 13
Renal changes in gout, 54
defect, uricæmia not necessarily due to, 123
depression, functional, 119
disease, abnormal protein loss in, 59
theory of gout, 117
uric acid infarcts, 151
Residence, choice of, 420
Respiratory disorders, spa treatment of, 450
organs, affections of, in gout, 303
Retinitis, nephritic, 324
Retrocedent gout, 39, 296
Rhazes’s views on gout, 6
Rheumatism, acute articular, differential diagnosis from acute gouty polyarthritis, 269, 270
isolation from gout, 15
muscular and nervous lesions associated with, 194
confused with gout, 215
chronic, tardy dissociation of, from chronic gout, 15
differential diagnosis from gout, 259
early use of term, 14
muscular, identification of, 16
Rheumatoid arthritis, 17
and gout, resemblance between, 113
differential diagnosis from chronic gout, 284
disturbance of purin metabolism in, 112
or atrophic arthritis, differential diagnosis from acute polyarticular gout, 272
Roberts’, Sir William, views on gout, 36
Salicylate group as alternative remedy in treatment of acute gout, 381
of colchicine in treatment of acute gout, 379
Salicylates in treatment of acute gout, contra-indicated, alkalies as substitute, 383
in treatment of chronic gout, 401
Salisbury diet in hyperchlorhydria, 353
method in reduction of obesity, 357
Salt in diet of gouty, 350
Scapular region, uratic deposits in, 235
Scheele’s discovery of uric acid, 8
Schnee four-cell bath in ionisation, 408
Sciatica associated with gout, treatment of, 411, 412
Scudamore’s definition of gout, 35
Seneca’s views on gout, 5
Septic conditions confounded with gout, 191
Serapion’s views on gout, 6
Serous membranes, uratic deposits in, in nephritis, 128
Sex incidence in gout, 41
Shivering at onset of acute paroxysm of gout, 188
Sidonal in treatment of acute gout, 383
Silk as underwear, 421
Sinusitis, latent, cause of systemic infections, 331
Skiagraphy in diagnosis of gout, 286
in diagnosis of villous synovitis, 281
in differential diagnosis of hypertrophic or osteo-arthritis, 291
in differential diagnosis of infective arthritis, 290
in differential diagnosis of rheumatoid or atrophic gout, 291
Skin, action of, consideration of, in treatment of gout, 337
appearances of, and gout, 45
defective elimination by, in chronic gout, treatment of, 400
Sodium biurate crystals in synovia, 52
ions in lymph stream, 146
mono-urate compound, 81
salicylates of, in treatment of acute gout, 382
Sole, gout in, 265
Solubilities of uric acid and urates in gouty blood, 82
Sool-Bader baths, 427
Spa, choice of, in treatment of gout, 440
treatment, duration of course of, 453
in acute gout, 385
of gout, principles of, 434
remarks on, 452
Spas from a national aspect, 454
Spermatozoa, Miescher’s researches in, 72
Spirits in gout, 370
Spleen, enlargement of, in gout, 190
enzymes in, 99
functional efficiency of, tests for, 338
Starchy foods in diet of gouty, 347
Static foot deformities, differential diagnosis from gout, 261
Stone in Norfolk, 29
Streptococci in tonsils, 183
Sub-infection theory of gout, 182, 183
Sub-thermal baths, 428
Succus entericus, action on nucleic acid, 100
Sugar in diet of gouty, 347
Sulphated alkaline waters, spas for, 442
waters, 441, 442
Sweetbreads in diet of gouty, effect of, 345, 346
Swine, guanine gout in, 100
Sydenham’s differentiation of rheumatism from gout, 15
views on gout, 7
Syncopes, local, of hand, in gout, 45
Synovia, appearance in, in acute gout, 52
Synovial fluid, reaction of, 52
Synovitis, gouty, relation to local foci of infection, 185
gummatous, differential diagnosis from chronic articular gout, 277
of knees, differential diagnosis from gout, 264
of tendo Achilles in referred pain in heel, 265
perforative, 57
villous, chronic, confusion with chronic gout, 279
clinical symptoms of, 280
static and non-gouty in origin, 280
Synthetic formation as source of uric acid, 84
of uric acid, 96
Syphilis, articular, muscular and nerve lesions associated with, 194
Syphilitic arthritis, secondary, differential diagnosis from acute gouty polyarthritis, 271
disease of tarsal joints, differential diagnosis from gout, 263
Taka-diastase, 392
Tarsal joints, gonococcal arthritis of, differential diagnosis from gout, 263
involved in gouty polyarthritis, 214
tuberculous and syphilitic disease of, differential diagnosis from gout, 263
Tartareous nature of tophi, views on, 8
Tea as beverage in gout, 361
Teeth, characteristic, in gout, 45
conditions in gout, 178
devitalised, examination of, in treatment of gout, 328
foci of infection, 53
Temperament, and gout, 44
Temperature curve of gout, 188
Tendo Achilles, involved in gout, 215
Tendon sheaths, involved in gout, 195
Tendons, gouty polyarthritis in, 214
uratic deposits in, 153
Test meals for HCL variations, 336
Tests, modern, for uric acid determination, disabilities of, 147
Theobromine, 85
Theophyllin, 85
Throat, gouty, 45
Thymine, 98
Thyminic acid, 80
in treatment of acute gout, 383
Thymus, enzymes in, 99
gland, nucleic acid derived from, 98
in diet of gouty patients, effect of, 345, 346
Tibia, tophi in skin over, 235
Tissue affinities for uric acid, 157
protein, 59
Tissues, human, concentrations of uric acid in, 159
retention capacity of, for uric acid, 158
effect on blood content, 138
Toe, big, gout in, differential diagnosis of, 259
initial outbreak of gout in, 37, 188
Tonsil, site of infection in gout, 180
Tonsillar sepsis, gout and, 178
Tonsillitis, acute, gout following, 53
in gouty subjects, 179
treatment of, in gout, 330
Tonsils, examination of, in diagnosis of articular gout, 249
foci of infection, 53
streptococci in, 183
Tophaceous deposits in chronic articular gout, 227
gout, 39
Tophi, analysis of, 150
antedating articular attacks, 202
auricular, 202
pain in, 233
clinical evolution of, 162
constitution of, 149
constitutional influences in, 161
diagnostic status of, 252
difficulty in detecting, 256
early stages of, confused with chilblains, 164
early views as to nature of, 7
evolution and distribution of, 231
formation preceding arthritic attacks, 164
frequency of, in gouty arthritis, 255
gouty, causation of, 154
formation of, 151
localisation of, 153
radiating, concentric and laminated structure of, 152
urate of soda, 150
importance of, in diagnosis of acute gouty polyarthritis, 269
in diagnosis of gout, 38
in eyes, significance of, 311
inflammatory nature of swellings in, 163
in relation to arthritis, 254
in relation to uricæmia, 155
sites of, 233
stage of small red swellings, 163
treatment of, in chronic articular gout, 407
Tophus formation in acute gout, 212
premonitory symptoms of, 203
in ear, sign of gout, 202
Trauma, local, effect on gout, 53
Traumatic lesions, differential diagnosis from gout, 260
Trousseau’s views on gout, 36
Tuberculous disease of tarsal joints, differential diagnosis from gout, 263
joint disease, differential diagnosis from chronic articular gout, 277
Toxæmia, alimentary, hydrochloric acid, 394
chronic, 182
Toxicity, low, of chemical products, in gout, 69
non-, of uric acid, 166
Ulna, tophi in skin over, 235
Uracil, 98
Urate of soda in gouty tophi, 150
Urates, deposition of, in eye, 309
Uratic depositions as criterion of gout, 37
deposits in gout, 54
in gout and nephritis, differentiation of, 129
in gout, localisation of, 153
in nephritis, 128
Uratosis in gout, 149
Urea and glycocine, interaction between, 84
end-product of protein metabolism, 63
excretion in gout, 66
excretion of ammonia as, 63
formation of, 62
Folin and Denis’s deductions, 64
seat of, 63
in blood in gout and nephritis (table), 121
Ureters, ligature of, 26
Uric acid, 75, 77
a normal constituent in blood, 135
an end-product, 70
as a derivative of nucleic acid, 73
blood content of, in various animals, 135
variations independently of diet, 142
chemical constitution of, 75
concentrations in human tissues, 159
content of blood and attacks of gout, relation between, 143
in gout, 139
deposition of, 22, 34
destruction of, 98, 104
determination of, disabilities of modern tests, 147
diathesis, 294, 295
discovery of, by Scheele, 8
estimation of, sources of fallacy, 145
excretions of, amount of, 75
exogenous, 85
in acute gout, 211
in gout, 108
anomalies in, 117
increased by radium emanation, 437
relation of leucocytosis to, 95
exogenous purins as source of, 84
formation of, Amberg and Jones’s scheme of, 103, 104
from nucleic acid, 98
gravel, spa treatment of, 451
in the blood, 78
forms of, 145
in gout and nephritis (table), 121
of gouty patients, discovery of, 21
organic combinations of, 79
infarcts, renal, 151
in relation to gout, 107
isomeric forms of, 81
kidney capacity for eliminating, 125
metabolism, influence of radium emanations on, 436
non-toxicity of, 166
of blood in disease (table), 137
output, endogenous, lowered, 111
exogenous, retarded, 109
physical properties of, 78
retention, capacity of tissues for, 158
solubilities of, 154
sources of, 83
synthetic formation of, 84, 96
theory of gout, 21
tissue affinities for, 157
variations in acute gout, 108
variations in chronic gout, 109
Wollaston’s researches on, 8
Uric-acidæmia, 295
Uricæmia and gout, 125
in gout, 133
in nephritis, 120
not cause, but result, of gout, 148
not necessarily due to renal defect, 123
not peculiar to nephritis, 124
significance of, 145
tophi in relation to, 155
Uricase, 87, 104
absence of, in man, 104
Uricolysis, 104
Uricolytic enzyme, 105
ferment, absence or diminution of, 106
Urine, alkapton in, 59
analysis of, in metabolism of gout, 113
in treatment of gout, 337
children’s, creatine in, 68
cystin in, 59
effects of guaiacum resin on, 405
examination of, in diagnosis of articular gout, 250
gouty, glyoxylic acid in, 65
human, daily excretion of uric acid, amount of, 83
scanty, before paroxysm of gout, 205
Urosin in treatment of acute gout, 383
Vaccine therapy in treatment of gout, 331
Vapour baths, 428
Vegetable cells, nucleic acid derived from, 98
Vegetables in diet of gouty, 348
Veins, engorged, before paroxysm of gout, 205
Venesection, 4
gout following, 178
Vichy bath, 428
Vidal’s atrophic form of arthritis deformans, 18
Vinegar in diet of gouty, 350
Viscera, functional capacity of, tests of, 338
Visceral organs, tendency to fibrosis in gout, 186
Vitamines, 340
Volumetric method of determination of uric acid in blood (Curtman and Lehrman), 134
Vomiting in acute paroxysms of gout, 333
Wade’s theory of nervous origin of gout, 32
Water, hot, advantages of, 360
value of, as beverage in gout, 359
“Water-soluble B,” 340
“Water-soluble C,” 340
Watson’s (Chalmers) researches on gout, 107, 172
Weir-Mitchell method in reduction of obesity, 357
Whisky in gout, 364, 370
Wines as beverages in gout, 364
general rules, 367
individual and, 365
importance of quality of, 366
Wollaston’s researches on uric acid, 8
Wrist, site of primary attack of gout, 267
Xanthine, 75, 77
Xanthine-oxidase, 99
Xanthosine-hydrolase, 102
X-ray examination of alimentary tract in treatment of gout, 336
Yeast, nucleic acid derived from, 98