“Capillary resistance test,” 212, 257
“Cardiorespiratory syndrome,” 200
Cardiovascular system, 199
Carrots, antiscorbutic value of, 159, 160
Central nervous system, gross pathology, 93
microscopic pathology, 104
Cereals, antiscorbutic value of, 170
germinated, 167
Cerebrospinal fluid, 203
Chlorides, 242–247
Citric acid theory, 23
Climate, 55
Complement, effect of scurvy on, 69
Complexion, characteristic change in, 176, 184
Complications of scurvy, 182, 202, 205, 217
Constipation, 27, 118–122, 207
Cord, spinal, pathology, 93, 104
Creatinine, 244
Cure, 236
D
Deficiency diseases, general discussion, 63, 248
Diastase, blood content of, 244
Diet, general, 59
Digestive disturbances, 78
Diphtheria, antitoxin in blood, 68
as complication of scurvy, 217
Drying, effect on vitamines of, 66
Duodenum, pathology, 89
E
Economic status, 55
Eczema, 195
Edema, 178, 184, 196
hunger, 256
war, 256
Eggs, antiscorbutic value of, 168
Endocrine organs, gross pathology, 92
microscopic pathology, 104
extracts of, as preventive, 172
theory of vitamine action, 72
Epiphyses, separation of, 96, 181, 198
Etiology, 35
exciting factors in, 60
Excretion of vitamine, 77
Expeditions, scurvy in Arctic, 10
Experimental scurvy, 111
pathogenesis, 116
pathology, 122
symptoms, 135
Eyeball, proptosis, 193
F
Familial tendency, 58
Fats, in diet, effect on scurvy, 59
Fœtus, effect of scorbutic diet on, 125
Food, excess of, 257
Foods, antiscorbutic, 143, 149
proprietary, 49
Fractures, 95
Frost-bite, 180
Fruit juices, 153
Fruits, fresh, 144
G
Generative organs, pathology, 104
Glands, endocrine, 72
changes in, 73, 92, 104
Glucose, blood content of, 244
Grapes, antiscorbutic value of, 158
Growth in scurvy, 213
Guinea-pig pathogenesis, 116
pathology, 122
relation to human, 115
symptoms, 135
Gums, 177, 181, 184
in infantile scurvy, 189
pathology of, 89, 100
H
Hair, changes in, 194
Heart, 200
gross pathology, 87
microscopic pathology, 99
Heat, effect on vitamine of, 65
Hemorrhages, 180, 189
as early symptoms, 178
distribution of, 84
gastric, 208
orbital, 193
subperiosteal, 95, 191
urinary, 204
History of scurvy, 1
Hog, effect of scorbutic diet on, 115
Hypophysis, 104
I
Infantile scurvy, history, 10
in artificially fed, 40
in breast-fed, 35
increase during World War, 21–22
relation to epidemic scurvy of adults, 15, 37
relation to rickets, 11, 110, 252
symptomatology, 183
Infection, as exciting factor, 60, 218
increased liability to, 68
effect on prognosis, 227
Intestines, gross pathology, 90
microscopic pathology, 100
Intravenous use of orange juice, 238
Irregularities in course of deficiency diseases, 78
J
Jaundice, 208
Joints, lesions of, 199
K
Kidneys, gross pathology, 91
microscopic pathology, 102
L
Laxatives, failure to cure with, 28, 207
Lemon juice, antiscorbutic value of, 153, 234
dried, 155, 232
ration in British Navy, 9, 144
Lentils, value as antiscorbutic, 167, 231
Lice, theory of transmission of scurvy by, 30
Lime juice, antiscorbutic value of, 156
fallacy in regard to, 149
use in British Navy, 144
Liver, gross pathology, 91
microscopic pathology, 101
Lungs, gross pathology, 88
microscopic pathology, 99
Lymph-nodes, gross pathology, 92
microscopic pathology, 101
M
Malnutrition, general, 58
Malt soup, 50
Marrow, changes in, 107
Meat, fresh, 147, 168
salt, 146
“Mehlnaerschaden” of Czerny, 256
Metabolism in scurvy, 241–247
Milk, alkalized, 50
amount necessary to prevent scurvy, 49, 117, 150
boiled, 44, 65
condensed, 48
dried, 46, 66, 152
effect of industrial methods on, 43
evaporated, 45
pasteurized, 40, 65
home vs. commercial, 42
sterilized, 44
breast, amount necessary to prevent scurvy, 36, 39, 153
as cause of beriberi, 39
cows, antiscorbutic value of, 40, 152
goats, antiscorbutic value of, 153
Mineral metabolism in scurvy, 241–247
Monkey, scurvy in, 114, 127
pathology, 128
Muscles, pathology, 97
N
Nails, changes in, 194
Necropsy reports, 82
Nephritis, 205
Nerves, peripheral, in guinea-pig
scurvy, 132
pathology, 105
Nervous system, effect of scurvy on, 202
Nutrition, general, in scurvy, 58, 59, 213
Nyctalopia, 182
O
Orange juice, antiscorbutic value of, 153, 234
“artificial,” 33
dried, 155
effect of alkalization of, 154
intravenous use of, 238
subcutaneous use of, 155
peel, antiscorbutic value of, 234
Osteogenesis imperfecta, 255
Osteomalacia, differentiation of, from scurvy, 255
Osteomyelitis, differentiation of, from scurvy, 222
Osteoporosis, differentiation of, from scurvy, 255
Osteotabes infantum, 109
P
Pains, as early symptom, 176
Pancreas, gross pathology, 91
microscopic pathology, 104
Pasteurized milk, 40
Pathogenesis of scurvy, theories of, 23
Pathology of scurvy in guinea-pig, 122
in man, gross, 83
microscopic, 96
in monkey, 128
Peas, antiscorbutic value of, 167, 231
Pellagra, 251
Phenols, excretion of, 245
Phosphate metabolism, 241–247
Pigeon, effect of scorbutic diet on, 114
Pneumonia, 202
Posture, characteristic, in guinea-pig, 136
Posture, characteristic, infant, 183
Potassium deficiency theory, 23
metabolism, 241–247
Potatoes, antiscorbutic value of, 6, 7, 146, 161, 235
Prevention of scurvy, 230
Prognosis, 225
Protein in diet, effect on scurvy, 59
Psychic element in scurvy, 57
Purpura, differential diagnosis, 221
Pyorrhœa, relation to lesion of gums, 181
R
Racial immunity, 56
Rats, effect of scorbutic diet on, 114, 115
Recurrent scurvy, 228
Respirations, 201
Retina, hemorrhages in, 105
Rheumatism, confusion with scurvy, 176, 220
Ribs, beading of, 197
pathology, 94
in guinea-pig, 129, 137
Rickets, relation of, to scurvy, 11, 110, 252
S
Sauerkraut, antiscorbutic value of, 145
Season, effect on incidence, 54
Sex, effect on incidence, 56
Shaking, effect on antiscorbutic factor, 68
Ship beriberi, 250
Skin, pathology, 96
Spleen, gross pathology, 91
microscopic pathology, 102
Sprue, 256
Starvation, pathology of, 125
Stomach, gross pathology, 89
microscopic pathology, 100
Storage of vitamine in body, 74
Streptococcus in blood in scurvy, 134
Subacute form of scurvy, 184
Subcutaneous use of antiscorbutics, 155
Swede, antiscorbutic value of, 162, 235
Symptomatology, in adult, 176
in infant, 183
Syphilis, congenital, differential diagnosis, 222, 223
T
Teeth, in guinea-pig scurvy, 130, 137
in human scurvy, 177
Temperature, in guinea-pig scurvy, 141
in human scurvy, 181, 216
Thymus, pathology of, 104
use of gland in treatment, 172
Thyroid, pathology of, 104
use of gland in treatment, 172
Tomatoes, canned, antiscorbutic value of, 166, 231, 234
in U. S. Army ration, 231
Toxic theory of pathogenesis of scurvy, 25
Treatment of scurvy, 230
duration of, 237
non-dietetic, 239
U
Ultra-violet rays, effect on antiscorbutics, 67
Urea content of blood, 244
of tissues, 245
Urine in scurvy, 204–206
V
Vegetable juices, keeping qualities of, 161
Vegetables, antiscorbutic value of 144, 158
canned, 166
dehydrated, 163
effect of heat on, 159
fresh, 144, 158
ripeness of, effect on antiscorbutic value, 160
Vitamine, antiscorbutic, general discussion of, 62
action of, 68, 69
as antitoxin, 69
as catalytic agent, 70
as nutriment, 69
blood content of, 76
effect of heat on, 65
of ultra-violet ray on, 67
excretion of, 77
Vitamine, experimental evidence for, 62
fate in body, 74, 77
relation to water-soluble factor, 65, 67
relation to antineuritic vitamine, 67
resistance to chemical and physical processes, 64
storage in body of, 74
theory of scurvy, 32
W
“White line” of Fraenkel, 128, 198
World War, scurvy in, 15
X
X-ray in diagnosis of scurvy, 128, 192, 198
Y
Yeast, antiscorbutic value of, 171