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[33]Close binspamdupenotthebestofftopicslownewsdaystalestupid freshfunnyinsightfulinterestingmaybe offtopicflamebaittrollredundantoverrated insightfulinterestinginformativefunnyunderrated descriptive typodupeerror [34]Sign up for the Slashdot newsletter! OR [35]check out the new Slashdot job board to browse remote jobs or jobs in your area Do you develop on GitHub? You can keep using GitHub but automatically [36]sync your GitHub releases to SourceForge quickly and easily with [37]this tool so your projects have a backup location, and get your project in front of SourceForge's nearly 30 million monthly users. It takes less than a minute. Get new users downloading your project releases today! [38]× 171544764 story [39]Earth [40]Is Natural Gas Actually On Par With Coal for Greenhouse Gas Emissions? [41](iop.org) [42]2 Posted by EditorDavid on Sunday August 06, 2023 @07:34AM from the emissions-impossible dept. Is natural gas really a cleaner alternative to coal and oil? That claim "is facing increasing scrutiny," writes Slashdot reader [43]sonlas: One significant concern with natural gas is the release of methane, a powerful greenhouse gas, during its extraction, production, transportation, and processing. Methane is approximately 30 times more effective at trapping heat in the atmosphere than CO2 over a 100-year period. (And methane leaks can occur at various stages of the gas supply chain, from wellhead emissions during drilling and extraction to leakage during transportation and distribution.) Additionally, intentional venting or flaring of methane also contributes to the problem. [44]An article published in Environmental Research Letters challenges the assumption that natural gas is a cleaner energy source compared to coal or oil. Their study takes into account the full lifecycle emissions of natural gas, including methane leakage rates, and arrives at a different conclusion. With a methane leakage rate of 7.5% and other relevant factors considered, the greenhouse gas emissions from natural gas can be on par with or even exceed those of coal. Even a lower methane leakage rate of 2% can diminish the environmental advantage of natural gas significantly. A key aspect of this study is its focus on real-world methane leakage rates. Aerial measurements conducted in various oil and gas production regions in the U.S. revealed substantial methane leak rates ranging from 0.65% to a staggering 66.2%. (Similar leakage rates have been identified in other parts of the world.) These findings raise serious concerns about the climate impact of natural gas and cast doubt on its role as a so-called "transition energy" in the quest for cleaner and more sustainable energy sources, especially liquefied natural gas... This complicates the search for sustainable energy solutions, especially in Europe where gas was included in the green taxonomy following a [45]push from Germany. apply tags__________ 171544664 story [46]Earth [47]America's Offshore Wind Potential is Huge but Untapped [48](theverge.com) [49]47 Posted by EditorDavid on Sunday August 06, 2023 @12:34AM from the call-me-the-breeze dept. A [50]new analysis "shows that over 4,000 gigawatts (GW) of offshore wind potential is available along the U.S. coastline," capable of fulfilling up to 25% of U.S. energy demand in 2050. (And it could also add $1.8 trillion in economy-boosting investment, while employing up to 390,000 workers.) This new analysis comes from Berkeley researchers, who worked with nonprofit clean energy research firm GridLab and climate policy think tank Energy Innovation, [51]reports the Verge: The Biden administration has [52]committed to halving the nation's emissions by the end of the decade and has plans to source electricity completely from carbon pollution-free energy by 2035. Adding to that urgency, U.S. electricity demand is forecast to nearly triple by 2050, according to the Berkeley report. On top of a growing economy, the clean energy transition means electrifying more vehicles and homes — all of which put more stress on the power grid unless more power supply comes online at a similar pace. To meet that demand and hit its climate goals, the report says the U.S. has to add 27 gigawatts of offshore wind and 85 GW of land-based wind and solar each year between 2035 and 2050. That timeline might still seem far away, but it's a big escalation of the Biden administration's current goal of deploying 30 GW of offshore wind by 2030. Europe, with an electricity grid about 70% the size of the U.S., already has about as much offshore wind capacity as the Biden administration hopes to build up by the end of the decade. Right now, wind energy makes up just over 10% of the [53]U.S. electricity mix, and nearly all of that comes from land-based turbines... For now, the U.S. has just two small wind farms off the coasts of Rhode Island and Virginia. [54]Construction started on the foundations for the nation's [55]first commercial-scale wind farm off Martha's Vineyard, Massachusetts, in June... Project costs have gone up with higher interest rates and rising prices for key commodities like steel, [56]Heatmap reports. That's led to power purchase agreements falling through for some projects in early development, including [57]plans in Rhode Island for an 884-megawatt wind farm that alone would have added more than 20 times as much generation capacity as the U.S. has today from offshore wind. Developers are struggling to make projects profitable without passing costs on to consumers... The study found a modest 2 to 3 percent increase in wholesale electricity costs with ambitious renewable energy deployment. But renewable energy costs have fallen so dramatically in the past that the researchers think those costs could wind up being smaller over time. The report points out that wind energy complements solar, by producing the most wind energy right when demand is peaking (in the summertime on the West Coast, and during the winter on the East Coast). apply tags__________ 171549664 story [58]Red Hat Software [59]Jon 'maddog' Hall Defends Red Hat's Re-Licensing of RHEL [60](lpi.org) [61]28 Posted by EditorDavid on Saturday August 05, 2023 @11:34PM from the going-to-the-source dept. In February of 1994 Jon "maddog" Hall [62]interviewed a young Linus Torvalds (then just 24). Nearly three decades later — as Hall approaches his 73rd birthday — he's shared a long essay looking back, but also [63]assessing today's controversy about Red Hat's licensing of RHEL. A (slightly- condensed] excerpt: [O]ver time some customers developed a pattern of purchasing a small number of RHEL systems, then using the "bug-for-bug" compatible version of Red Hat from some other distribution. This, of course, saved the customer money, however it also reduced the amount of revenue that Red Hat received for the same amount of work. This forced Red Hat to charge more for each license they sold, or lay off Red Hat employees, or not do projects they might have otherwise funded. So recently Red Hat/IBM made a business decision to limit their customers to those who would buy a license from them for every single system that would run RHEL and only distribute their source-code and the information necessary on how to build that distribution to those customers. Therefore the people who receive those binaries would receive the sources so they could fix bugs and extend the operating system as they wished.....this was, and is, the essence of the GPL. Most, if not all, of the articles I have read have said something along the lines of "IBM/Red Hat seem to be following the GPL..but...but...but... the community! " Which community? There are plenty of distributions for people who do not need the same level of engineering and support that IBM and Red Hat offer. Red Hat, and IBM, continue to send their changes for GPLed code "upstream" to flow down to all the other distributions. They continue to share ideas with the larger community. [...] I now see a lot of people coming out of the woodwork and beating their breasts and saying how they are going to protect the investment of people who want to use RHEL for free [...] So far I have seen four different distributions saying that they will continue the production of "not RHEL", generating even more distributions for the average user to say "which one should I use"? If they really want to do this, why not just work together to produce one good one? Why not make their own distributions a RHEL competitor? How long will they keep beating their breasts when they find out that they can not make any money at doing it? SuSE said that they would invest ten million dollars in developing a competitor to RHEL. Fantastic! COMPETE. Create an enterprise competitor to Red Hat with the same business channels, world-wide support team, etc. etc. You will find it is not inexpensive to do that. Ten million may get you started. My answer to all this? RHEL customers will have to decide what they want to do. I am sure that IBM and Red Hat hope that their customers will see the value of RHEL and the support that Red Hat/IBM and their channel partners provide for it. The rest of the customers who just want to buy one copy of RHEL and then run a "free" distribution on all their other systems no matter how it is created, well it seems that IBM does not want to do business with them anymore, so they will have to go to other suppliers who have enterprise capable distributions of Linux and who can tolerate that type of customer. [...] I want to make sure people know that I do not have any hate for people and companies who set business conditions as long as they do not violate the licenses they are under. Business is business. However I will point out that as "evil" as Red Hat and IBM have been portrayed in this business change there is no mention at all of all the companies that support Open Source "Permissive Licenses", which do not guarantee the sources to their end users, or offer only "Closed Source" Licenses....who do not allow and have never allowed clones to be made....these people and companies do not have any right to throw stones (and you know who you are). Red Hat and IBM are making their sources available to all those who receive their binaries under contract. That is the GPL. For all the researchers, students, hobbyists and people with little or no money, there are literally hundreds of distributions that they can choose, and many that run across other interesting architectures that RHEL does not even address. Hall [64]answered questions from Slashdot users in 2000 and again [65]in 2013. Further reading: Red Hat CEO Jim Whitehurst [66]answering questions from Slashdot readers in 2017. apply tags__________ 171549712 story [67]The Almighty Buck [68]Some Wells Fargo Customers Say Their Deposits Aren't Showing Up in Their Accounts [69](nbcnews.com) [70]41 Posted by EditorDavid on Saturday August 05, 2023 @09:34PM from the deposit-slipping dept. "For the second time this year, Wells Fargo acknowledged that [71]deposits were not showing up in customers' accounts," reports NBC News: In an emailed statement Friday morning, a Wells Fargo representative said the issue was affecting a "limited number of customers," and that "the vast majority" of instances had been resolved before noon, while the "few remaining" would be resolved soon. This week's incident mirrored one [72]encountered by Wells Fargo customers in March, which the company then blamed on an unspecified "technical issue...." Customers nationwide appeared to be affected by this week's outage. Jeani Cortez, a single, disabled, self-employed accountant and Alaska resident, says she was supposed to have paid her rent, gas, electric and internet payments for the month by now with funds she deposited Wednesday. She said she was told Friday by a Wells Fargo representative that she would not be able to access her deposit for another three to five business days. She'd earlier been told that Wells Fargo could send her a letter to give to her creditors; that too has not arrived. apply tags__________ 171545124 story [73]Encryption [74]Ask Slashdot: What's the Best (Encrypted) Password Manager? [75]110 Posted by EditorDavid on Saturday August 05, 2023 @06:34PM from the swordfish dept. For storing passwords, Slashdot reader [76]eggegick has a simple, easy solution: "I use Vim to keep my passwords in an encrypted file." But what's the easiest solution for people who don't use Vim? My wife is not a Linux geek like I am, so she's using [free and open-source] [77]KeePass. It's relatively simple to install and use, but I seem to recall it used to be even much simpler... Does anybody know of a really simple password manager or encrypting notepad? I've looked at a number of them, and they use Java or Javascript, or they involve an external web site, or they have way too many features, or they use an installation program. Or Windows Defender objects to them. Share your own suggestions and thoughts in the comments. What's the best (encrypted) password manager? apply tags__________ 171548826 story [78]Power [79]Judge Tosses Criminal Charges Against South Carolina Nuclear Executive - But Case May Continue [80](apnews.com) [81]33 Posted by EditorDavid on Saturday August 05, 2023 @05:34PM from the full-court-pressed dept. An anonymous reader shared [82]this report from the Associated Press: A judge has ordered criminal charges dropped against the final executive accused of [83]lying about problems building two nuclear reactors in South Carolina that were abandoned without generating a watt of power. The judge tossed the charges Wednesday because ratepayers of the utility that lost [84]billions of dollars on the project were improperly allowed on the grand jury that indicted Westinghouse Electric Co. executive Jeffrey Benjamin. But federal judge Mary Geiger Lewis also ruled that nothing is stopping prosecutors from properly seeking another indictment. "We're not going away," said assistant U.S. Attorney Winston Holliday, who said prosecutors are still reviewing the ruling to decide their next steps... The project [85]fell apart in 2017 after nearly a decade of work, when executives and regulators determined construction of the reactors was so hopelessly behind schedule they could not get nearly $2 billion of tax breaks needed to help pay for the work. SCANA contracted with Westinghouse to build the reactors. Prosecutors said Benjamin , who was in charge of major projects, knew of delays and cost overruns but lied to regulators, utility executives and others. The lies led to electric rate increases while keeping the price of SCANA's stock from plummeting... Two former SCANA executives have been sentenced to federal prison after pleading guilty to their roles in lying to ratepayers, regulators and investors. Former CEO [86]Kevin Marsh received two years while chief operating officer [87]Stephen Byrne was sentenced to 15 months. Former Westinghouse project director [88]Carl Churchman has pleaded guilty to lying to FBI agents investigating the project's failure and is awaiting sentencing. apply tags__________ 171548202 story [89]Social Networks [90]Are the Reddit Protests Over? [91](gizmodo.com) [92]54 Posted by EditorDavid on Saturday August 05, 2023 @04:34PM from the what's-Snoo? dept. "Three of Reddit's biggest communities are no longer focused entirely on John Oliver in a form of protest against Reddit," [93]reports the Verge. Gizmodo argues that this means "[94]the Reddit protest is finally over. Reddit won." Despite the infinite blackout threats, most moderators relented as the weeks rolled by. Three major holdouts were r/aww, r/pics, and r/videos, some of Reddit's largest communities that account for more than 91 million subscribers. The three subreddits reopened weeks ago but adopted rules by popular vote that prohibited content that did not feature HBO's John Oliver, rendering the forums useless for their previous purposes. For a while, the subreddits stood strong, but r/videos was the first to backpedal, dropping the John Oliver rule but requiring all posts to feature profanity. Soon that rule was abandoned as well. Last week, the moderators of r/aww announced the John Oliver rule was over, and over the weekend r/pics quietly gave up the protest as well, as reported [95]by the Verge. "More than a month has passed, and as things on the internet go, the passion for the protest has waned and people's attention has shifted to other things," an r/aww moderator wrote in [96]a post about the rule change. According to [97]Reddark, a site that tracks the subreddit protest, 1,843 of the original 8,829 protesting communities are still dark. But most of these are small communities, and today the only protesting subreddit with over 10 million subscribers is r/fitness. The Verge: Two other big communities have switched back, too. r/pics (with more than 30 million subscribers) had perhaps been the most visibly tied to John Oliver: Oliver himself [98]posted a series of silly photos specifically for the community to use, and at one point, the moderators of r/pics [99]invited Oliver to join the mod team. But sometime recently, r/pics removed any obvious trace of its connections to John Oliver; the Wayback Machine shows that r/pics was all about John Oliver [100]as of Friday but [101]no longer on Saturday... r/videos (with more than 26 million subscribers) actually dropped its John Oliver rule back in June; it was replaced by a new rule that all posts needed to contain profanity in the title [102]after a community vote. Earlier this month, the r/videos moderators reverted the rules to what they were before the protests started... In June, more than 8,000 communities went dark to protest the API pricing, but in the weeks since, many subreddits have [103]opened back up (some after [104]feeling pressure from Reddit) and are operating as they did before. Many users are still disgruntled, though, and made their feelings known [105]in July's r/Place canvas. More than 1,800 subreddits are still private in protest, [106]according to the Reddark tracker. Some key passages from [107]the moderator's announcement at r/aww: What about the protest, though; did we win? The short answer is no. The long answer is also no, as Reddit's minimal attempts at positive outreach remain overshadowed by the plethora of depressing developments... At the end of the day, Reddit's API changes have gone into effect. They did not extend the transition period or reduce the exorbitant prices. They granted exemptions to a few apps and moderation tools, but that's about it. The best thing I can say is that they did honor their commitment to ensuring the continued functionality of some mod tools... Despite some reassurances and promises from Reddit, their conduct and these changes have driven away many developers, leading to the shutdown of some tools and an [108]uncertain future for others. The announcement with a link labeled "and more importantly," which leads to a picture with [109]a message for Reddit CEO Steve Huffman (who uses the name "Spez" when posting on Reddit.) apply tags__________ 171545022 story [110]ISS [111]SpaceX Studies Use of Starship as a Space Station [112](arstechnica.com) [113]25 Posted by EditorDavid on Saturday August 05, 2023 @03:34PM from the open-for-orbits dept. Recently Ars Technica reported on "[114]another application for SpaceX's Starship architecture that the company is studying," adding that NASA "is on board to lend expertise. "Though still in a nascent phase of tech development, the effort could result in repurposing Starship into a commercial space station, something NASA has a keen interest in because there are no plans for a government-owned research lab in low-Earth orbit after the International Space Station is decommissioned after 2030." NASA [115]announced last month a new round of agreements with seven commercial companies, including SpaceX. The Collaborations for Commercial Space Capabilities (CCSC) program is an effort established to advance private sector development of emerging products and services that could be available to customers — including NASA — in approximately five to seven years... NASA passed over SpaceX's bid for a funded space station development agreement in 2021, identifying concerns about SpaceX's plans for scaling its life-support system to enable long-duration missions and SpaceX's plan for a single docking port, among other issues. The space agency isn't providing any funding for the new CCSC effort, which includes the Starship space station concept, but the government will support the industry with technical expertise, including expert assessments, lessons learned, technologies, and data. Apart from the SpaceX agreement, NASA said it will provide non-financial support to Blue Origin's initiative to develop a crew spacecraft for orbital missions that would launch on the company's New Glenn rocket. The agency also supports Northrop Grumman's development of a human-tended research platform in low-Earth orbit to work alongside the company's planned space station. The other companies NASA picked for unfunded agreements were: Sierra Space's proposal for a crewed version of its Dream Chaser spacecraft, [116]Vast's concept for a privately owned space station, ThinkOrbital's plan to develop welding, cutting, inspection, and additive manufacturing technology for construction work in space, and Special Aerospace Services for collaboration on an autonomous maneuvering unit to assist, or potentially replace, spacewalkers working outside a space station. Despite the lack of NASA funding, the new collaboration announcement with SpaceX laid out — in broad strokes, at least — one of the directions SpaceX may want to take Starship. NASA said it will work with SpaceX on an "integrated low-Earth orbit architecture" that includes the Starship vehicle and other SpaceX programs, including the Dragon crew capsule and Starlink broadband network. The artice links to a recent NASA [117]document detailing SpaceX's space station concept. Phil McAlister, who heads NASA's commercial spaceflight division, says its size and reduced cost "could have a far-reaching impact on the sustainable development of the low-Earth orbit) economy... "Adding increased confidence is the company's plan to self-fund Starship development from its launch and satellite enterprises." Thanks to long-time Slashdot reader [118]Amiga Trombone for sharing the article. apply tags__________ 171545230 story [119]The Courts [120]Federal Judge Clears Way for US Antitrust Case Against Google [121](msn.com) [122]26 Posted by EditorDavid on Saturday August 05, 2023 @02:34PM from the I'm-feeling-lucky dept. The Washington Post reports: A federal judge said the Department of Justice's [123]landmark case alleging Google's dominance over the online search business is anti-competitive [124]can go ahead, throwing out some of the government's claims but ruling that a trial is still necessary. Google had asked for the judge to make a ruling before the trial, which is scheduled for September. Some of the government's claims, including those put together by a consortium of state attorneys general that argued the way Google designed its search engine page was unfairly harming competitors like Yelp, were dismissed. But D.C. District Court Judge Amit Mehta said the allegations that Google's overall business practices constitute a monopoly that violates the 1890 Sherman Antitrust Act still deserve a trial. "This is a significant victory for Google, knocking out several claims and narrowing the range of activities at issue for trial," said David Olson, an associate professor and antitrust expert at Boston College's law school. "Having said that, the strongest claims against Google remain, so Google still remains at risk of a significant antitrust ruling against it." The trial will be a major test for Google and the massive business empire it has assembled over the past two decades. The company is still the dominant portal to the internet, exercising immense power over what people see online... The eventual ruling will also be seen as a test for the U.S. government's more aggressive posture on antitrust. apply tags__________ 171544702 story [125]Japan [126]Scientists in Japan Develop Experimental Alzheimer's Vaccine Showing Promise in Mice [127](gizmodo.com) [128]31 Posted by EditorDavid on Saturday August 05, 2023 @01:34PM from the food-for-thoughts dept. "Scientists in Japan may be at the start of a truly monumental accomplishment: a vaccine that can slow or delay the progression of Alzheimer's disease," [129]reports Gizmodo: In preliminary research released this week, the vaccine appeared to reduce inflammation and other important biomarkers in the brains of mice with Alzheimer's-like illness, while also improving their awareness. More research will be needed before this vaccine can be tested in humans, however. The experimental vaccine is being developed primarily by scientists from Juntendo University in Japan. It's intended to work by training the immune system to go after certain [130]senescent cells, aging cells that no longer divide to make more of themselves, but instead stick around in the body. These cells aren't necessarily harmful, and some play a vital role in healing and other life functions. But they've also been linked to a variety of age-related diseases, including Alzheimer's. The vaccine specifically targets senescent cells that produce high levels of something called senescence-associated glycoprotein, or SAGP. Other research has suggested that people with Alzheimer's tend to have brains filled with these cells in particular. The team tested their vaccine on mice bred to have brains that develop the same sort of gradual destruction seen in humans with Alzheimer's. apply tags__________ 171547774 story [131]Open Source [132]Vim's Creator Bram Moolenaar Dies at Age 62 [133](google.com) [134]47 Posted by EditorDavid on Saturday August 05, 2023 @12:35PM from the exiting-Vim dept. Bram Moolenaar was Vim's creator/maintainer/benevolent-dictator for life. Early this morning his family shared sad news [135]on the Vim-announce Google Group. "It is with a heavy heart that we have to inform you that Bram Moolenaar passed away on 3 August 2023." Moolenaar was 62 years old, and died from "a medical condition that progressed quickly over the last few weeks." "Bram dedicated a large part of his life to VIM and he was very proud of the VIM community that you are all part of." Anyone who's used Vim has seen evidence of Moolenaar's generosity. "Vim is Charityware," Moolenaar wrote in its pioneering license. "You can use and copy it as much as you like, but you are encouraged to make a [136]donation for needy children in Uganda." Moolenaar pioneered the concept of charityware [137]decades ago, and also helped to popularize its adoption. To this day Vim users can still view the license by typing the command :help Uganda or :help ICCF. And Vim's [138]sponsor FAQ notes that "Each registered Vim user and sponsor who donates at least 10 euro will be able to vote for new features." Moolenaar's [139]personal web site also includes photos from his travels around the world, and YouTube has [140]some videos of talks and interviews [141]with Moolenaar. He was still [142]committing changes to Vim up until a month ago. In the comments below long-time Slashdot reader [143]bads shares a link to [144]a post from long-time Vim contributor Christian Brabandt : Bram was a great leader to the Vim community and I really enjoyed working with him over the past years, since I became involved with the development of Vim almost 20 years ago. Bram was of great inspiration in creating a great community, helping people with his charity and he was a great mentor. And now he left too soon. We lost a great leader and I regret never having met him in person. However to all of the community: I will continue and I hope all of the other contributors will also keep up the good work. I do have access to the Vim homepage and the Vim organization (not sure if all the rights, but I am sure we will work on the details in the near future...) I hope together we will be able to continue successfully. apply tags__________ 171547376 story [145]Space [146]NASA Finally Restores Communication with Voyager 2 After Two Weeks [147](apnews.com) [148]40 Posted by EditorDavid on Saturday August 05, 2023 @11:34AM from the far-far-away dept. "NASA has reestablished full communications with Voyager 2," according to [149]a mission update posted Friday: The agency's Deep Space Network facility in Canberra, Australia, sent the equivalent of an interstellar "shout" more than 12.3 billion miles (19.9 billion kilometers) to Voyager 2, instructing the spacecraft to reorient itself and turn its antenna back to Earth. With a one-way light time of 18.5 hours for the command to reach Voyager, it took 37 hours for mission controllers to learn whether the command worked. At 12:29 a.m. EDT on Aug. 4, the spacecraft began returning science and telemetry data, indicating it is operating normally and that it remains on its expected trajectory. "Had the Earth-based signals not reached Voyager 2, the spacecraft is already programmed to reorient itself multiple times a year to keep its antenna pointing in our planet's direction," [150]CNN points out. "The next reset was already scheduled for October 15. But the team didn't want to wait that long..." After controllers [151]sent the wrong command to the 46-year-old spacecraft, Voyager 2's antenna needed to be shifted "a mere 2 degrees," [152]notes The Associated Press: Voyager 2 has been hurtling through space since its launch in 1977 to explore the outer solar system. Launched two weeks later, its twin, Voyager 1, is now the most distant spacecraft — 15 billion miles (24 billion kilometers) away — and still in contact. As long as their plutonium power holds, the Voyagers may be alive and well for the 50th anniversary of their launch in 2027, according to Dodd. Among the scientific tidbits they've beamed back in recent years include details about the interstellar magnetic field and the abundance of cosmic rays. apply tags__________ 171543192 story [153]Medicine [154]A New Mode of Cancer Treatment [155]30 Posted by [156]BeauHD on Saturday August 05, 2023 @10:34AM from the there's-a-pill-for-everything dept. As detailed in a paper [157]published in Cell Chemical Biology, researchers have developed a "cancer-killing pill" [158]capable of destroying solid tumors while leaving healthy cells unaffected. The new drug has been in development for 20 years and is now undergoing pre-clinical research in the U.S.. Derek Lowe, a medicinal chemist and freelance writer on science and pharmaceutical topics, writes about the new paper via Science Magazine: It's about a molecule designated [159]AOH1996, which seems to have a unique mode of action in tumor cells, one that might make it more more selective for those as compared to normal ones. The key target here is a protein called PCNA (from its old name of "proliferating cell nuclear antigen"). [...] The current molecule is a traditional direct small molecule binder that is selective for caPCNA over the regular type, which is a very attractive advantage to explore. The team behind it has been working on it for several years now to validate that mechanism, and the new paper linked first above is their report of going all the way into animal models. AOH1996 is a very unremarkable-looking molecule - to be honest, it looks like the sort of stuff that you used to see in old combinatorial chemistry libraries in the late 90s and early 2000s, a couple of aryl-rich groups strung together with amide bonds. It's certainly not going to be the most soluble stuff in the world, but they seem to have been able to formulate it. But I'm definitely not going to make fun of any chemical structure that works! [...] The new paper shows preclinical toxicity testing in two species (mice and dogs), which is what you need to get to human trials. It seems to pass those very well, with no signs of trouble at 6x the effective dose in either species. And if you were throwing DSBs all over the place in normal tissues, believe me, you'd see tox. It is clean in an Ames test, for example. As for efficacy, in cell assays the concentration needed for 50% growth inhibition across 70 different cancer cell lines averaged around 300nM, while it showed no toxic effects on various non-cancer lines up to 10 micromolar (at least a 30x window). The affected cells show cell-cycle arrest, replication stress, apoptosis, and so on. And application of AOH1996 along with other known chemotherapy agents made the cells much more sensitive to those, presumably because they couldn't deal with those on top of the problems that AOH1996 was already causing. It also shows growth arrest in xenograft tumors in mouse models, with a no-effect dose at least six times its effective dose, and combination therapy with a topoisomerase inhibitor showed even more significant effects. The compound has entered a Phase I trial in humans on the basis of the above data, and I very much look forward to seeing it advance to Phase II, where it will doubtless be used in combination with several existing therapies. I hope that human cancers will prove vulnerable to this new mode of attack in the clinic, and that they are not able to mutate around it with new forms of caPCNA too quickly, either. The comparison with the peptide agent mentioned above will be especially interesting, too. There's only one way to find out - good luck to everyone involved! apply tags__________ 171544586 story [160]Medicine [161]EPA Approved a Chevron Fuel Ingredient That Has a Lifetime Cancer Risk [162]101 Posted by [163]BeauHD on Saturday August 05, 2023 @09:00AM from the not-a-good-look dept. An anonymous reader quotes a report from ProPublica: The Environmental Protection Agency approved a component of boat fuel made from discarded plastic that the agency's own risk formula determined was so hazardous, [164]everyone exposed to the substance continually over a lifetime would be expected to develop cancer. Current and former EPA scientists said that threat level is unheard of. It is a million times higher than what the agency usually considers acceptable for new chemicals and six times worse than the risk of lung cancer from a lifetime of smoking. Federal law requires the EPA to conduct safety reviews before allowing new chemical products onto the market. If the agency finds that a substance causes unreasonable risk to health or the environment, the EPA is not allowed to approve it without first finding ways to reduce that risk. But the agency did not do that in this case. Instead, the EPA decided its scientists were overstating the risks and gave Chevron the go-ahead to make the new boat fuel ingredient at its refinery in Pascagoula, Mississippi. Though the substance can poison air and contaminate water, EPA officials mandated no remedies other than requiring workers to wear gloves, records show. ProPublica and the Guardian in February [165]reported on the risks of other new plastic-based Chevron fuels that were also approved under an EPA program that the agency had touted as a "[166]climate-friendly" way to boost alternatives to petroleum-based fuels. That story was based on an EPA consent order, a legally binding document the agency issues to address risks to health or the environment. In the Chevron consent order, the highest noted risk came from a jet fuel that was expected to create air pollution so toxic that 1 out of 4 people exposed to it over a lifetime could get cancer. In February, ProPublica and the Guardian asked the EPA for its scientists' risk assessment, which underpinned the consent order. The agency declined to provide it, so ProPublica requested it under the Freedom of Information Act. The [167]203-page risk assessment revealed that, for the boat fuel ingredient, there was a far higher risk that was not in the consent order. EPA scientists included figures that made it possible for ProPublica to calculate the lifetime cancer risk from breathing air pollution that comes from a boat engine burning the fuel. That calculation, which was confirmed by the EPA, came out to 1.3 in 1, meaning every person exposed to it over the course of a full lifetime would be expected to get cancer. Another serious cancer risk associated with the boat fuel ingredient that was documented in the risk assessment was also missing from the consent order. For every 100 people who ate fish raised in water contaminated with that same product over a lifetime, seven would be expected to develop cancer -- a risk that's 70,000 times what the agency usually considers acceptable. When asked why it didn't include those sky-high risks in the consent order, the EPA acknowledged having made a mistake. This information "was inadvertently not included in the consent order," an agency spokesperson said in an email. [...] The risk assessment makes it clear that cancer is not the only problem. Some of the new fuels pose additional risks to infants, the document said, but the EPA didn't quantify the effects or do anything to limit those harms, and the agency wouldn't answer questions about them. Some of these newly approved toxic chemicals are expected to persist in nature and accumulate in living things, the risk assessment said. That combination is supposed to trigger additional restrictions under EPA policy, including prohibitions on releasing the chemicals into water. Yet the agency lists the risk from eating fish contaminated with several of the compounds, suggesting they are expected to get into water. When asked about this, an EPA spokesperson wrote that the agency's testing protocols for persistence, bioaccumulation and toxicity are "unsuitable for complex mixtures" and contended that these substances are similar to existing petroleum-based fuels. The EPA did address the concerns in June when it proposed a rule that "would require companies to contact the agency before making any of 18 fuels and related compounds listed in the Chevron consent order," notes ProPublica. "The EPA would then have the option of requiring tests to ensure that the oil used to create the new fuels doesn't contain unsafe contaminants often found in plastic, including certain flame retardants, heavy metals, dioxins and PFAS. If approved, the rule will require Chevron to undergo such a review before producing the fuels, according to the EPA." apply tags__________ 171544522 story [168]Google [169]Google Offers Employees On-Campus Hotel 'Special' To Lure Workers Back To the Office [170](cnbc.com) [171]35 Posted by [172]BeauHD on Saturday August 05, 2023 @06:00AM from the what-has-this-world-come-to dept. For $99 a night, full-time employees of Google [173]can stay at an on-campus hotel in Mountain View in what the company is deeming a "Summer Special." According to CNBC who obtained the materials, "the special will run through Sept. 30 in hopes it'll 'make it easier for Googlers to transition to the hybrid workplace.'" From the report: Since the promotion is for unapproved business travel, the company will not reimburse their stays, but will require employees to use their personal credit cards, the special's description states. "Just imagine no commute to the office in the morning and instead, you could have an extra hour of sleep and less friction," the description reads. "Next, you could walk out of your room and quickly grab a delicious breakfast or get a workout in before work starts." The ad goes on to say that after the work day ends, "you could enjoy a quiet evening on top of the rooftop deck or take in one of the fun local activities." The Google-owned hotel is situated on a newer campus in Mountain View, California, that it opened last year. The 42-acre campus is adjacent to NASA's Ames Research Center and has capacity to house 4,000 employees working on its ads products, the company said upon its opening. Some employees have commented on the hotel deal in internal discussion forums. One highly rated meme showed movie clips that included a scene in the movie "Mean Girls," where the main character played by Lindsey Lohan says "No, thank you." "Now I can give some of my pay back to Google," another highly rated meme read. Another meme joked that living on campus for the summer could disrupt "work-life balance." At $99 a night, the hotel would amount to roughly $3,000 a month, employees pointed out in internal discussions viewed by CNBC. One employee pointed out that hotel amenities were not to be ignored. "I pay more and get a lot less in total for my apartment," wrote one employee in a discussion thread. "Though admittedly where I live is much better." Another thought it was still too expensive. "If it was around $60 a night, that could be a fine-ish alternative to apartments, but $99? No thanks." "I would've totally done it, had it fit a certain profile: $3k rent all-in, fully-furnished, unlimited meals, paid utilities, plus housekeeping/cleaning every day," another employee wrote. Another hypothesized the move could be a way to reduce vacancy at the hotel after Google cut corporate travel budgets. apply tags__________ [174]« Newer [175]Older » Slashdot Top Deals Slashdot Top Deals [176]Slashdot Deals Slashdot Poll What's your favorite machine to play games on? (*) Xbox ( ) PlayStation ( ) Nintendo ( ) PC ( ) Smartphone (BUTTON) vote now [177]Read the 36 comments | 2873 votes Looks like someone has already voted from this IP. If you would like to vote please login and try again. What's your favorite machine to play games on? 0 Percentage of others that also voted for: * [178]view results * Or * * [179]view more [180]Read the 36 comments | 2873 voted Most Discussed * 148 comments [181]Google Offers On-Campus Hotel 'Special' To Help Lure Workers Back To the Office * 107 comments [182]Ask Slashdot: What's the Best (Encrypted) Password Manager? * 103 comments [183]Twitch Streamer in Custody After Giveaway Clogs Downtown NYC with Crowd of Thousands * 96 comments [184]EPA Approved a Chevron Fuel Ingredient That Has a Lifetime Cancer Risk * 90 comments [185]Threads User Count Falls To New Lows Developers * [186]The Most Prolific Packager For Alpine Linux Is Stepping Away * [187]Salesforce Executive Shares 'Four Ways Coders Can Fight the Climate Crisis' * [188]Python's Steering Council Plans to Make Its 'Global Interpreter Lock' Optional * [189]Ask Slashdot: What Happens After Every Programmer is Using AI? * [190]RHEL Response Discussed by SFC Conference's Panel - Including a New Enterprise Linux Standard [191]This Day on Slashdot 2017 [192]Google Engineer's Leaked 'Gender Diversity' Essay Draws Massive Response 1122 comments 2011 [193]United States Loses S&P AAA Credit Rating 1239 comments 2008 [194]New Olympics Scoring: No More Perfect 10.0 722 comments 2003 [195]SCO Targets US Government, TiVo 1539 comments 2002 [196]Shattering Windows 965 comments [197]Sourceforge Top Downloads * [198]TrueType core fonts 2.2B downloads * [199]Notepad++ Plugin Mgr 1.5B downloads * [200]VLC media player 899M downloads * [201]eMule 686M downloads * [202]MinGW 631M downloads Powered By [203]sf [204]Slashdot * [205]Today * [206]Saturday * [207]Friday * [208]Thursday * [209]Wednesday * [210]Tuesday * [211]Monday * [212]Sunday * [213]Submit Story Computer Science is merely the post-Turing decline in formal systems theory. * [214]FAQ * [215]Story Archive * [216]Hall of Fame * [217]Advertising * [218]Terms * [219]Privacy Statement * [220]About * [221]Feedback * [222]Mobile View * [223]Blog * * (BUTTON) Icon Do Not Sell My Personal Information Copyright © 2023 Slashdot Media. 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