Posts by Jopo89@mas.to
(DIR) Post #9wpDMiuAfr1tm48EEa by Jopo89@mas.to
2020-07-06T23:54:23Z
0 likes, 1 repeats
@commandlinekid đ understood. Donât worry the journals are nothing like as bad as BBC etc, theyâll be like once an hour, if that! Yeah exactly, better things to fuss about.
(DIR) Post #9wpDYa4tJpKRs9nfUG by Jopo89@mas.to
2020-07-06T23:56:31Z
0 likes, 1 repeats
@commandlinekid itâs a slick process youâve got going on. Thatâs how I came across you, with the BBC Breaking. They are perfect for what we need!
(DIR) Post #9wpoWr0H7ERo5hgG8G by Jopo89@mas.to
2020-07-07T06:50:47Z
0 likes, 1 repeats
@razvan đđđ âHello. I am out of the office right now. I am attending a plague and shall get back to you.â
(DIR) Post #9wpoZPmcmB0GXPW6Qi by Jopo89@mas.to
2020-07-07T06:51:16Z
0 likes, 1 repeats
@commandlinekid noted! Deal.
(DIR) Post #9wr7s5ZeELj7eJ1c8G by Jopo89@mas.to
2020-07-07T22:02:14Z
0 likes, 1 repeats
Local micronutrients affect inflammatory response inside cells -metabolism links metabolism https://www.nature.com/articles/s41556-020-0526-8
(DIR) Post #9wrzdupMmf2Zn34Grw by Jopo89@mas.to
2020-07-08T08:04:45Z
0 likes, 1 repeats
Are you even a millennial if you donât order a flat white or coconut latte now coffee shops have opened
(DIR) Post #9ws0ZMIZJtHdUp7NHE by Jopo89@mas.to
2020-07-08T08:15:07Z
0 likes, 1 repeats
Calcium precipitates very rapidly because it quickly exchanges a hydration shell for other bonds in solution. This makes it an an obvious choice for mineralising weight bearing structures in an organism and why itâs kept compartmentalised inside cells.
(DIR) Post #9wsWAskYj4uBR6aBwe by Jopo89@mas.to
2020-07-08T14:09:16Z
0 likes, 1 repeats
Glycosaminoglycans coat inside of endothelium and presence in urine prognosticates sepsis and ARDS severity https://www.atsjournals.org/doi/10.1164/rccm.201511-2281OC
(DIR) Post #9wtERZrqa0MhmNlMSe by Jopo89@mas.to
2020-07-08T22:25:17Z
0 likes, 1 repeats
On the evolution of sodium potassium homeostasis. Why is potassium so high intracellularly when it is not abundant in sea water where life evolved? As usual geothermal vents seem to be the answer. Where geothermal material escapes sea vents through mud holes it has a liquid NaCl phase and a vapour right in NH3, hydrogen sulf, CO2 and K+ > Na. Sodium is then actively extruded out of cells. K+ is an important core for things like the ribosome which transcribes RNA
(DIR) Post #9wtEg2EVuisro9G7Bg by Jopo89@mas.to
2020-07-08T22:27:55Z
0 likes, 1 repeats
And moreover for important kinases and trafficking enzymes. The other gases are interesting because they along with carbon monoxide and nitric oxide represent gaseous signalling molecules common to all eukaryotic cells. Gas signalling is older than the ancestor we share with a chicken but beyond nitric oxide we donât think of it much. Itâs extremely Paracrine and acts locally. #science #evolution #biology #medicine
(DIR) Post #9wtFxMd1RCg5wKY8B6 by Jopo89@mas.to
2020-07-08T22:42:15Z
0 likes, 1 repeats
Lactic Acidosis & Metformin. Metformin is a diabetic drug used to reduce liver gluconeogenesis via hepatic AMPK enzymes. However it has a direct effect on mitochondria. Although the exact mechanism is not clearly known (and transport inside the mitochondria double matrix varies according to carrier protein and time of day) clinically relevant doses of metformin WILL affect Complex I of the ETC. The key thing about this complex is electrons can pass forward as well backwards through it
(DIR) Post #9wtGEYh7pTMIHkfSZU by Jopo89@mas.to
2020-07-08T22:45:21Z
0 likes, 1 repeats
This is reverse electron transfer and it blasts free radicals everywhere. Metformin inhibits this complex and can reduce reverse electron transfer however in absence of forward flow also through the ETC no ATP is generated from aerobic respiration and TCA Substrates accumulate. Only lactate based metabolism is then possible. So metformin can cause profound lactic acidosis. Curiously it does however protect in chronic inflammation and confers survival benefit secondary to ROS inhibition
(DIR) Post #9wtGTDsZVDcu4U0w76 by Jopo89@mas.to
2020-07-08T22:48:00Z
0 likes, 1 repeats
In addition to glucose effects. Donât if been used in sepsis? Metformin toxicity is under diagnosed and should be considered in AKI/renal accumulation in an odd lactate situation. It is reversible and improves with filtration. It has potential to give a false impression of illness severity if not addressed. Mitochondrial inhibition was originally part of reason not ideal post MI for a few days. #medicine #FOAMed #science
(DIR) Post #9wu5j3dkQzAcbwO94a by Jopo89@mas.to
2020-07-09T08:22:17Z
0 likes, 1 repeats
@0x11de784a well Twitter is just becoming very inflammatory the past few weeks and I think people have just reached a point it would be nice to have a space that didnât make you miserable and stressed every day, to chat about the good stuff! So suggested it
(DIR) Post #9wupYFZYKFRGKBD7q4 by Jopo89@mas.to
2020-07-09T16:55:47Z
0 likes, 1 repeats
@0x11de784a I think for us it's covid. Lockdown has made a lot of free time and interest for people to start following doctors, leading to more exposure, more disagreements, more politics....no chill discussion!
(DIR) Post #9wuxUKUStkHc3ITM7U by Jopo89@mas.to
2020-07-09T18:24:43Z
0 likes, 1 repeats
poor maya rivera
(DIR) Post #9wuxWIBYRHe9TyYya8 by Jopo89@mas.to
2020-07-09T18:25:03Z
0 likes, 1 repeats
so sad about naya rivera. Her poor son.
(DIR) Post #9wuxdrmeU2zbuqWj1E by Jopo89@mas.to
2020-07-09T18:26:28Z
0 likes, 1 repeats
one of the next awful things to hit 2020 would be a cocoa blight
(DIR) Post #9wuxggxhAwoBDm2W1o by Jopo89@mas.to
2020-07-09T18:26:58Z
0 likes, 1 repeats
not looking forward to nights, sigh, they have been so very busy in the last few weeks.
(DIR) Post #9wuyUekhfHC2qbmst6 by Jopo89@mas.to
2020-07-09T18:35:57Z
0 likes, 1 repeats
@Kathleen there is that!