Subj : A neurobehavioral signature of risk for To : All From : ScienceDaily Date : Tue Jul 11 2023 22:30:30 A neurobehavioral signature of risk for mania Date: July 11, 2023 Source: Elsevier Summary: Mania, in which mood and energy level are extremely elevated for at least a week, and hypomania, which is less severe and lasts at least four days, are the defining features of bipolar spectrum disorders (BSD) and can be the most disruptive symptoms. A new study now identifies a signature of risk for developing future mania or hypomania. Facebook Twitter Pinterest LinkedIN Email ========================================================================== FULL STORY ========================================================================== Mania, in which mood and energy level are extremely elevated for at least a week, and hypomania, which is less severe and lasts at least four days, are the defining features of bipolar spectrum disorders (BSD) and can be the most disruptive symptoms. A new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier, now identifies a signature of risk for developing future mania or hypomania. BSD are psychiatric conditions that typically emerge in young adulthood, often severely disrupting lives and requiring intensive treatments. Mania risk has remained challenging for clinicians to predict; the ability to do so would aid in directing treatments to at-risk patients sooner. The researchers, led by Adriane M. Soehner, PhD, at the University of Pittsburgh, built on previous research showing that heightened reward motivation and sleep-circadian rhythm disruption are associated with mania/ hypomania onset. Brain imaging studies have also shown that BSD is associated with elevated reward expectancy activation in the left ventrolateral prefrontal cortex, a key reward- and salience-processing hub. For the current study, Dr. Soehner and colleagues clustered these markers together; they hypothesized that a signature of increased mania risk would be marked by elevated reward sensitivity, impulsivity, and sleep-circadian characteristics. Young adult participants, who did not have a diagnosis of BSD, completed assessments and underwent functional magnetic resonance imaging. About half the participants also underwent follow-up assessments at six and 12 months. Three "profiles" emerged from the sample: one healthy, one at moderate risk, and one at high risk. Individuals at high risk had elevated mania symptoms at baseline compared to the other two groups. Over the 12-month follow-up interval, mania symptoms in both the high-risk and moderate-risk groups exceeded the healthy group. Dr. Soehner said of the findings, "Here, we identified neurobehavioral profiles based on reward sensitivity, impulsivity, and sleep-circadian characteristics that help distinguish those with elevated mania vulnerability. These characteristics, in combination, may help detect mania risk and provide targets to guide and monitor early interventions." Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, said of the work, "New findings such as these highlight our emerging ability to combine neurobiological and clinical measures to identify groups of patients at highest risk for serious mental health problems such as mania, allowing for early identification and intervention for those at highest risk. Future research is needed to show that this can lead to reduced suffering and better outcomes in individuals identified in this way." * RELATED_TOPICS o Health_&_Medicine # Sleep_Disorder_Research # Asthma # Mental_Health_Research # Multiple_Sclerosis_Research o Mind_&_Brain # Bipolar_Disorder # Sleep_Disorders # Mental_Health # Behavior * RELATED_TERMS o Bipolar_disorder o Mental_illness o PMS o Measles o Controversy_about_ADHD o Clinical_depression o Salmonella_infection o Pregnancy ========================================================================== Print Email Share ========================================================================== ****** 1 ****** ***** 2 ***** **** 3 **** *** 4 *** ** 5 ** Breaking this hour ========================================================================== * Revolutionary_Electric_Artificial_Muscles * Age_of_Universe:_26.7,_Not_13.7,_Billion_Years * City_Ground_Is_Deforming:_Buildings_Aren't_Ready * The_Sound_of_Silence?_People_Hear_It * 36-Million-Year_Geological_Cycle_Drives_... * Six_Foods_to_Boost_Cardiovascular_Health * Cystic_Fibrosis:_Lasting_Improvement * Artificial_Cells_Demonstrate_That_'Life_... * Advice_to_Limit_High-Fat_Dairy_Foods_Challenged * First_Snapshots_of_Fermion_Pairs Trending Topics this week ========================================================================== HEALTH_&_MEDICINE Cholesterol Mental_Health_Research Brain_Tumor MIND_&_BRAIN Intelligence Brain_Injury Educational_Psychology LIVING_&_WELL Healthy_Aging Nutrition Child_Development ========================================================================== Strange & Offbeat ========================================================================== HEALTH_&_MEDICINE Revolutionary_Self-Sensing_Electric_Artificial_Muscles These_Lollipops_Could_'Sweeten'_Diagnostic_Testing_for_Kids_and_Adults_Alike Holograms_for_Life:_Improving_IVF_Success MIND_&_BRAIN The_Sound_of_Silence?_Researchers_Demonstrate_People_Hear_It AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Everyone's_Brain_Has_a_Pain_Fingerprint_--_New_Research_Has_Revealed_for_the First_Time LIVING_&_WELL Grocery_Store_Carts_Set_to_Help_Diagnose_Common_Heart_Rhythm_Disorder_and Prevent_Stroke Illusions_Are_in_the_Eye,_Not_the_Mind Amputees_Feel_Warmth_in_Their_Missing_Hand Story Source: Materials provided by Elsevier. Note: Content may be edited for style and length. ========================================================================== Journal Reference: 1. Adriane M. Soehner, Meredith L. Wallace, Kale Edmiston, Henry W. Chase, Jeannette Lockovich, Haris Aslam, Richelle Stiffler, Simona Graur, Alex Skeba, Genna Bebko, Osasumwen E. Benjamin, Yiming Wang, Mary L. Phillips. Neurobehavioral Reward and Sleep-Circadian Profiles Predict Present and Next-Year Mania/Hypomania Symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2023; DOI: 10.1016/j.bpsc.2023.04.012 ========================================================================== Link to news story: https://www.sciencedaily.com/releases/2023/07/230711133131.htm --- up 1 year, 19 weeks, 1 day, 10 hours, 50 minutes * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3) .