Subj : Demonstration of safety of microbiota tr To : All From : ScienceDaily Date : Thu Jul 06 2023 22:30:32 Demonstration of safety of microbiota transplant therapy in stem cell transplant and leukemia patients Date: July 6, 2023 Source: University of Minnesota Medical School Summary: A new study has demonstrated the safety of using microbiota transplant therapy (MTT) in patients with acute myeloid leukemia (AML) -- a type of blood cancer -- and recipients of hematopoietic cell transplantation (HCT). Facebook Twitter Pinterest LinkedIN Email ========================================================================== FULL STORY ========================================================================== Published in theJournal of Clinical Oncology, University of Minnesota Medical School researchers led a study that demonstrated the safety of using microbiota transplant therapy (MTT) in patients with acute myeloid leukemia (AML) -- a type of blood cancer -- and recipients of hematopoietic cell transplantation (HCT). Current treatment for patients with AML and who receive HCT includes powerful chemotherapy, which can damage their immune system and intestinal lining. Because of this, patients typically require antibiotics to fight and prevent infections. These antibiotics also kill healthy gut microbes, which may worsen treatment outcomes. The goal of MTT is to restore beneficial microbes in the recipient's gut. "Microbiota transplants are classified as drugs by the U.S. Food and Drug Administration. However, they truly are an entirely different and new class of drugs, and we need to develop and understand their pharmacology. This requires standardized formulations and figuring out the optimal dosing regimens," said Alexander Khoruts, MD, director of the University of Minnesota Microbiota Therapeutics Program. In a randomized, double-blind study, the research team compared the outcomes of MTT for two groups: patients with AML and HCT recipients. They used a novel, standardized preparation of donor microbiota called MTP-101C, which is formulated in capsules that are taken orally. After each course of antibiotics, patients received either MTT or a placebo. The study found the rate of infections was lower in HCT and AML patients that received active MTT relative to the patients that received the placebo. However, the difference did not reach statistical significance. Overall, the study showed MTT was safe and partially improved the imbalance of gut bacteria in patients who had received HCT or had AML. However, it did not significantly reduce the rate of infections in these patients. These results will serve as the basis for a larger follow-up study, which will use a more aggressive MTT protocol with the microbiota compound manufactured by the University of Minnesota Microbiota Therapeutics Program. The program has been the world leader in the development and manufacturing of microbiota-based therapeutics over the past decade. It is working to develop effective and practical restorative microbiota therapies for multiple clinical indications, some of which include infections with Clostridioides difficile, inflammatory bowel disease and different applications in cancer. This study was funded largely through local philanthropy, including the Chainbreaker Cancer Fundraiser bike event held in 2017, as well as the nonprofit Achieving Cures Together. Additional support was provided by the National Institutes of Health's National Center for Advancing Translational Sciences [KL2TR002492 and UL1TR002494] and the National Cancer Institute [P30CA07759]. * RELATED_TOPICS o Health_&_Medicine # Leukemia # Diseases_and_Conditions # Wounds_and_Healing # Today's_Healthcare # Patient_Education_and_Counseling # Lung_Cancer # Pharmacology # Multiple_Sclerosis_Research * RELATED_TERMS o Bone_marrow_transplant o Leukemia o Skin_grafting o Kidney_transplantation o Stem_cell o Adult_stem_cell o Cancer o Bone_marrow ========================================================================== Print Email Share ========================================================================== ****** 1 ****** ***** 2 ***** **** 3 **** *** 4 *** ** 5 ** Breaking this hour ========================================================================== * First_Snapshots_of_Fermion_Pairs * Why_No_Kangaroos_in_Bali;_No_Tigers_in_Australia * New_Route_for_Treating_Cancer:_Chromosomes * Giant_Stone_Artefacts_Found:_Prehistoric_Tools * Astonishing_Secrets_of_Tunicate_Origins * Most_Distant_Active_Supermassive_Black_Hole * Creative_People_Enjoy_Idle_Time_More_Than_Others * Restoring_Fragile_X_Protein_Production * Earth's_Solid_Metal_Sphere_Is_'Textured' * Elephants_Vary_Their_Dinner_Menu_Day-To-Day Trending Topics this week ========================================================================== HEALTH_&_MEDICINE Patient_Education_and_Counseling Birth_Defects Cholesterol MIND_&_BRAIN Educational_Psychology Stroke Autism LIVING_&_WELL Fitness Healthy_Aging Nutrition ========================================================================== Strange & Offbeat ========================================================================== HEALTH_&_MEDICINE Holograms_for_Life:_Improving_IVF_Success Grocery_Store_Carts_Set_to_Help_Diagnose_Common_Heart_Rhythm_Disorder_and Prevent_Stroke DNA_Can_Fold_Into_Complex_Shapes_to_Execute_New_Functions MIND_&_BRAIN AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Everyone's_Brain_Has_a_Pain_Fingerprint_--_New_Research_Has_Revealed_for_the First_Time Scientists_Discover_Spiral-Shaped_Signals_That_Organize_Brain_Activity LIVING_&_WELL Illusions_Are_in_the_Eye,_Not_the_Mind Amputees_Feel_Warmth_in_Their_Missing_Hand Why_Do_Champagne_Bubbles_Rise_the_Way_They_Do?_Scientists'_New_Discovery_Is Worthy_of_a_Toast Story Source: Materials provided by University_of_Minnesota_Medical_School. Original written by Alex Smith. Note: Content may be edited for style and length. ========================================================================== Journal Reference: 1. Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Mohammad H. Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda J. Kabage, Sharon Lopez, Shernan G. Holtan, Daniel J. Weisdorf, Alexander Khoruts, Christopher Staley. Randomized Double- Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML. Journal of Clinical Oncology, 2023; DOI: 10.1200/JCO.22.02366 ========================================================================== Link to news story: https://www.sciencedaily.com/releases/2023/07/230706124523.htm --- up 1 year, 18 weeks, 3 days, 10 hours, 50 minutes * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3) .