From owner-btk-mca@hgmp.mrc.ac.uk Fri Jun 29 00:07:15 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 55E7917A9D for ; Fri, 29 Jun 2001 00:07:15 +0100 (BST) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id ACBF417AE3 for ; Fri, 29 Jun 2001 00:07:12 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A652717A9E for ; Fri, 29 Jun 2001 00:07:06 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id AAA19731 for btk-mca-list@hgmp.mrc.ac.uk; Fri, 29 Jun 2001 00:00:10 +0100 (BST) X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: dbk@aber.ac.uk ("Douglas Kell") X-Newsgroups: bionet.metabolic-reg Subject: Re: Enzymes!?! Date: 29 Jun 2001 00:00:06 +0100 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 43 Message-ID: <3B3BC41C.11314.12BC051@localhost> References: <77754d4.0106281433.5c179d8f@posting.google.com> Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: 7BIT X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id B1B3717A9E for ; Fri, 29 Jun 2001 00:00:02 +0100 (BST) X-Received: from cefni.aber.ac.uk (cefni.aber.ac.uk [144.124.16.40]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id BDD5C17A9D for ; Thu, 28 Jun 2001 23:59:57 +0100 (BST) X-Received: from pcdbk.isdn.aber.ac.uk ([193.61.215.25] helo=pcghah) by cefni.aber.ac.uk with esmtp (Exim 3.21 #1) id 15FklQ-0004i9-00; Thu, 28 Jun 2001 23:59:57 +0100 X-To: btk-mca@hgmp.mrc.ac.uk, pkuzmic@biokin.com (Petr Kuzmic) X-Priority: normal X-In-reply-to: <77754d4.0106281433.5c179d8f@posting.google.com> X-Mailer: Pegasus Mail for Win32 (v3.12c) To: btk-mca@hgmp.mrc.ac.uk Sender: owner-btk-mca@hgmp.mrc.ac.uk Precedence: bulk Definitely. In a short post I didn't seek to cover even the main threads, which are vast, but if I'd added even one more this would have been it. Hans Frauenfelder was/is of top importance in keeping in the forefront of people's connsciousnes the importance of fluctuations in proteins (Mb as an honorary enzyme...), and in developing ways to deal with them usefully in both exoperimental and theoretical terms. The concept of configurational entropy as a get-out clause for how you can sort yourself out in the fluctuating world while not ostensibly cheating on the 2nd Law [itself a statistical concept in its usual form, which opens up a lot of difficulties when discussing non-equilibrium states as so-called "ensembles" - which by definition they are not] is, as far as I know, mainly developed by him. I believe it will be found to have much in common (wrt thermodynamics, mechanistics and function) with the neutral networks (note the t in neutral, that's not a typo for neural) that are discussed in the context of molecular (and directed) evolution. Over to experts here I hope. The prize ('how enzymes really work') is worth it. DBK. > In addition to the very useful references posted by Douglas, I will > get on one of MY favored soap boxes and mention the name of Hans > Frauenfelder. Here are some of his papers, mostly elaborating the > concept of "ruggen energy landscape" and using myoglobin as the sample > system: > [chomp] ******************************************************************** *(Prof.) Douglas B. Kell Phone: +44 1970 622334 * *Director of Research * *Institute of Biological Sciences Fax: +44 1970 622354 * *Cledwyn Building * *University of Wales, Email: dbk@aber.ac.uk * *Aberystwyth SY23 3DD, U.K. http://gepasi.dbs.aber.ac.uk/ * ******************************************************************** ******************************************************************** --- .