From owner-cellbiol@net.bio.net Sun Dec 08 22:00:00 1996
Path: biosci!STUDENTS.WISC.EDU!iboronen
From: iboronen@STUDENTS.WISC.EDU (Igor Boronenkov)
Newsgroups: bionet.cellbiol
Subject: Postdoctoral and Scientist Positions in Cellular Signal Transduction
Date: 9 Dec 1996 10:40:33 -0800
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UNIVERSITY OF WISCONSIN
POSTDOCTORAL AND SCIENTIST POSITIONS

	A Postdoctoral and a Scientist Position are available to study
phosphoinositide and protein kinases in cellular signal transduction. 
The work has two major focuses:  The phosphoinositide cycle in nuclei
and putative regulation of nuclear protein kinases and cellular
functions by this signaling pathway;  and the regulation of
phosphoinositide second messenger generation by receptors, in particular
receptors which stimulate synthesis of PI3,4P2 and PI3,4,5P3.  
	A wide variety of approaches are used to study these cellular signaling
pathways.  Thus, experience in either cell biology, biochemistry, and/or
molecular biology is essential.  The successful applicants must be able
to work both independently and synergistically as a member of an
agressive, yet supportive, research team.  

Relevant references:
Hay, J., Fisette, P.F., Jenkins, G.H., Fukami, K., Takenawa, T.,
Anderson, R.A., and Martin, T.M.J. (1995) ATP-dependent inositide
phosphorylation required for Ca2+-activated secretion.  Nature 374,
173-177. 
Boronenkov, I.V. and Anderson, R.A. (1995) The sequence of a
phosphatidylinositol 4-phosphate 5-kinase defines a novel family of
lipid kinases.  J. Biol. Chem. 270, 2881-2884.
Yamamoto, A., Dewald, D., Boronenkov, I.V., Anderson, R.A., Emer, S.,
and Koshland, D. (1995)  FAB1 gene of Saccharomyces cerevisiae encodes a
PIP 5-kinase homolog necessary for vacuolar, nuclear and cell surface
processes.  Mol. Biol. Cell  6, 525-539. 
Gross, S.D., Hoffman, D.P., Fisette, P.F., Baas, P., and Anderson, R.A.
(1995)  A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase
I associates with small synaptic vesicles and phosphorylates a subset of
vesicle proteins. J. Cell Biol., 130, 711-724. 
Ren, X.-D., Bokoch, G.M., Jenkins, G.H., Anderson, R.A., and Schwartz,
M.A. (1996) Physical association of the small GTPase Rho with a 68 kDa
phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol.
Cell  7, 435-442.
Lojeins, J., Boronenkov, I, Parker, G., and Anderson, R.A.  (1996)
Phosphatidylinositol 4-phosphate 5-kinases: A novel family of lipid
kinases.  Advances in Enzyme Regulation 36, 115-140.
Zhang, J., and Anderson, R.A. (1996)  Casein kinase Ia and aL:
Alternatively mRNA spliced protein kinases with different substrate
kinetics.  Biochemistry (In Press). 
Loijens, J. C.  and Anderson, R.A. (1996)  Type I
phosphatidylinositol-4-phosphate 5-kinases are distinct members of this
novel lipid kinase family.  J. Biol. Chem. 271: 32937-32943.
Castellino, A.M., Parker, G., Boronenkov, I., Anderson, R.A.
(corresponding author), and M.V. Chao.  A novel interaction between the
juxtamembrane region of the p55 TNF receptor and phosphatidylinositol
4-phosphate 5-kinase. J. Biol. Chem. (In Press).

Telephone:  (608) 262-3753 (office); E-mail raanders@facstaff.wisc.edu;
FAX:  (608) 262-1257

Send C.V. and three letters of reference to: 

					Dr. Richard A. Anderson
					Molecular and Cellular
					Pharmacology Program
					The Department of Pharamcology
					University of Wisconsin
					1300 University Avenue
					Madison, WI 53706

.