From owner-btk-mca@hgmp.mrc.ac.uk Thu Jun 28 23:37:17 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 65B2A17A9D for ; Thu, 28 Jun 2001 23:37:16 +0100 (BST) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 305BE17AE2 for ; Thu, 28 Jun 2001 23:37:13 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 17A4617A9E for ; Thu, 28 Jun 2001 23:37:07 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id XAA19706 for btk-mca-list@hgmp.mrc.ac.uk; Thu, 28 Jun 2001 23:33:55 +0100 (BST) X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: pkuzmic@biokin.com (Petr Kuzmic) X-Newsgroups: bionet.metabolic-reg Subject: Re: Enzymes!?! Date: 28 Jun 2001 15:33:50 -0700 Organization: http://groups.google.com/ Lines: 117 Message-ID: <77754d4.0106281433.5c179d8f@posting.google.com> References: <3B3B0687.22335.3D386F38@localhost> Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 8bit X-Complaints-To: groups-support@google.com To: btk-mca@hgmp.mrc.ac.uk Sender: owner-btk-mca@hgmp.mrc.ac.uk Precedence: bulk dbk@aber.ac.uk ("Douglas Kell") wrote in message news:<3B3B0687.22335.3D386F38@localhost>... > I should know better than to respond to this...., but.... > > Transition state theory (TST) is not the only game in town so far as > explaining 'how' enzymes work. In fact its chief assumption (a static > energy barrier) is OBVIOUSLY untrue for the highly fluctuating things > that enzymes are. ... In addition to the very useful references posted by Douglas, I will get on one of MY favored soap boxes and mention the name of Hans Frauenfelder. Here are some of his papers, mostly elaborating the concept of "ruggen energy landscape" and using myoglobin as the sample system: Frauenfelder H, McMahon BH, Austin RH, et al. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin P NATL ACAD SCI USA 98 (5): 2370-2374 FEB 27 2001 McMahon B, Frauenfelder H, Austin R, et al. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin BIOPHYS J 80 (1): 1180 Part 2 JAN 2001 Frauenfelder H, McMahon BH Energy landscape and fluctuations in proteins ANN PHYS-BERLIN 9 (9-10): 655-667 2000 McMahon BH, Stojkovic BP, Hay J, et al. Structure/dynamics/function relationship in myoglobin BIOPHYS J 78 (1): 1671Pos Part 2 JAN 2000 McMahon BH, Stjkovic BP, Frauenfelder H, et al. Density functional theory calculation of barrier to ligand binding in myoglobin BIOPHYS J 76 (1): A23-A23 Part 2 JAN 1999 Frauenfelder H, Wolynes PG, Austin RH Biological physics REV MOD PHYS 71 (2): S419-S430 Sp. Iss. SI MAR 1999 Frauenfelder H, Leeson DT The energy landscape in non-biological and biological molecules NAT STRUCT BIOL 5 (9): 757-759 SEP 1998 Stojkovic BP, McMahon BH, Frauenfelder H, et al. Molecular dynamics calculations of CO binding to myoglobin with an abinitio calculated heme - CO interaction potential. ABSTR PAP AM CHEM S 216: 030-BIOL Part 1 AUG 23 1998 McMahon BH, Stojkovic BP, Frauenfelder H, et al. Ab-initio calculation of heme - CO interaction potential. ABSTR PAP AM CHEM S 216: 031-BIOL Part 1 AUG 23 1998 McMahon BH, Muller JD, Stojkovic B, et al. Structural interpretation of CO recombination to myoglobin - (5-320 K) BIOPHYS J 74 (2): A236-A236 Part 2 FEB 1998 Frauenfelder H, McMahon B Dynamics and function of proteins: The search for general concepts P NATL ACAD SCI USA 95 (9): 4795-4797 APR 28 1998 Frauenfelder H, Bishop AR, Garcia A, et al. Landscape paradigms in physics and biology - Concepts, structures and dynamics - The 16th annual international conference of the Center for Nonlinear Studies - Los Alamos, NM, USA, 13-17 May 1996 - Preface PHYSICA D 107 (2-4): R5-R5 SEP 1 1997 Nienhaus GU, Muller JD, McMahon BH, et al. Exploring the conformational energy landscape of proteins PHYSICA D 107 (2-4): 297-311 SEP 1 1997 Garcia AE, Krumhansl JA, Frauenfelder H Variations on a theme by Debye and Waller: From simple crystals to proteins PROTEINS 29 (2): 153-160 OCT 1997 Frauenfelder H Proteins: A challenging many-body problem PHILOS MAG B 74 (5): 579-585 NOV 1996 Johnson JB, Lamb DC, Frauenfelder H, et al. Ligand binding to heme proteins .6. Interconversion of taxonomic substates in carbonmonoxymyoglobin BIOPHYS J 71 (3): 1563-1573 SEP 1996 FRAUENFELDER H COMPLEXITY IN PROTEINS NAT STRUCT BIOL 2 (10): 821-823 OCT 1995 FRAUENFELDER H FROM SYMMETRY TO COMPLEXITY CHINESE J PHYS 32 (6): 1045-1050 Part 2 DEC 1994 FRAUENFELDER H PROTEINS - PARADIGMS OF COMPLEX-SYSTEMS EXPERIENTIA 51 (3): 200-203 MAR 15 1995 CHU K, ERNST RM, FRAUENFELDER H, et al. LIGHT-INDUCED AND THERMAL RELAXATION IN A PROTEIN PHYS REV LETT 74 (13): 2607-2610 MAR 27 1995 FRAUENFELDER H THE MOSSBAUER-EFFECT AND BIOLOGICAL PHYSICS HYPERFINE INTERACT 90 (1-4): 21-25 1994 - Petr ------------------------------------------------------- P e t r K u z m i c, Ph. D. * BioKin Ltd. 1652 S. Grand Ave. * Suite 337 * Pullman, WA 99163 509.334.4131 * 509.332.3493 fax * http://www.biokin.com .