From owner-celegans@net.bio.net Tue Jul 01 23:00:00 1997 Path: biosci!daresbury!not-for-mail From: "Dr. Thomas Egwang" Newsgroups: bionet.celegans Subject: Knock out of farnesyltransferase Date: 2 Jul 1997 05:47:16 +0100 Lines: 21 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <5pcmgl$9o5@mserv1.dl.ac.uk> X-Sender: egwang@imul.com Original-To: celegans@dl.ac.uk Dear colleagues, My laboratory is currently characterising the farnesyltransferase (beta- and alpha-subunits) of filarial nematodes as a possible drug target. One major problem we face is the validation of any biochemical drug target in parasitic nematodes. We would like to use C. elegans as a surrogate model in which to validate farnesyltransferase. In this regard, we are looking for collaborators in the C. elegans community who might be interested in colloborating with us in knocking out the homologous gene in C. elegans to see whether farnesyltransferase is critical for survival in this nematode. We would be prepared to clone the gene in C. elegans in our laboratory. I would appreciate hearing from interested C. elegans molecular biologists. Dr Thomas G. Egwang Medical Biotechnology Laboratories P.o. Box 9364 Kampala Uganda Fax 256-41-268251 e-mail: egwang@imul.com .