From owner-bionews@hgmp.mrc.ac.uk Sat Jan 25 04:26:24 2003 Return-Path: X-Original-To: bionews-outgoing Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id 5F7997D1A4 for ; Sat, 25 Jan 2003 04:26:24 +0000 (GMT) X-Original-To: bionews-list@hgmp.mrc.ac.uk Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id E478C7D182 for ; Sat, 25 Jan 2003 04:26:23 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6022) id 2F2357D1A4; Sat, 25 Jan 2003 04:26:19 +0000 (GMT) X-Original-To: bionews-submit@hgmp.mrc.ac.uk Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id DADE17D224 for ; Fri, 24 Jan 2003 11:00:02 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id D168B7D256 for ; Fri, 24 Jan 2003 11:00:01 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id LAA20374 for bionet-announce@net.bio.net; Fri, 24 Jan 2003 11:00:01 GMT To: bionet-announce@net.bio.net From: Sam Griffiths-Jones Newsgroups: bionet.announce,bionet.software Subject: Rfam 3.0 - a database of RNA families Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Trace: niobium.hgmp.mrc.ac.uk 1043406001 20372 193.62.207.221 (24 Jan 2003 11:00:01 GMT) X-Complaints-To: news@net.bio.net NNTP-Posting-Date: Fri, 24 Jan 2003 11:00:01 +0000 (UTC) Date: Sat, 25 Jan 2003 04:26:19 +0000 (GMT) Sender: owner-bionews@hgmp.mrc.ac.uk Precedence: bulk Rfam: A database of multiple alignments and covariance models of non-coding RNA families ---------------------------------------------------------------- Rfam is a database of structure-annotated multiple sequence alignments, covariance models and family annotation for a number of non-coding RNA families. Rfam 3.0 contains 36 such families. The seed alignments are hand curated and aligned using available data, and covariance models are built from these alignments using the INFERNAL 0.54 software suite (http://infernal.wustl.edu/). The full alignments are created by searching a subset of the EMBL nucleotide database using the covariance model, and then aligning all hits above a family specific threshold to the model. Rfam 3.0 annotates 70911 regions in the EMBL database. Rfam is available on the web at the following URLs: http://www.sanger.ac.uk/Software/Rfam/ http://rfam.wustl.edu/ The database is also available for download in flatfile format from: ftp://ftp.sanger.ac.uk/pub/databases/Rfam/ ftp://ftp.genetics.wustl.edu/pub/eddy/Rfam/ For local searching the INFERNAL package is also required: http://infernal.wustl.edu/ Rfam is maintained by a consortium of researchers at the Wellcome Trust Sanger Institute, Cambridge, UK, and Washington University, St. Louis, USA. ---------------------------------- January 2003 - The Rfam Consortium .