From owner-announce@net.bio.net Wed Oct 14 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Janine Sieja Hagerman Newsgroups: bionet.announce Subject: BLAST Server at NCGR Date: 15 Oct 1998 10:53:16 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 47 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <199810151727.LAA25293@ncgr.ncgr.org> NNTP-Posting-Host: net.bio.net The National Center for Genome Resources is pleased to announce the availability of BLAST (Basic Local Alignment Search Tool) starting today (Oct. 15). Coming soon, the Center will also offer other powerful similarity search methods, including Smith-Waterman. Please visit http://seqsim.ncgr.org to conduct free searches and analysis. NCGR's recent acquisition of two specialized DeCypher ES-1920 servers, produced by TimeLogic Corp., allows us to offer these computationally intensive search algorithms. The Center is the first to offer a free, publicly accessible DeCypher server linked to a public sequence database, our Genome Sequence DataBase (GSDB). GSDB contains additional data, unique data sets and annotation not found in other public databases. This breadth of genomic data, combined with the power to analyze data and free access, represents a formidable resource. Nowhere else can users benefit from the combination of comprehensive data access and cutting-edge analysis tools. The DeCypher servers perform a variety of algorithms; in addition to BLAST, NCGR will provide Smith-Waterman, Frame Search, Symmetric Frame Independent, Profile Search in early 1999; and ClustalW by the end of 1998. To support flexibility in similarity searching, NCGR provides searchable subsets of its databases. You may customize your target set by selecting a single or multiple subsets. NCGR is unique among public sequence databases in offering this extremely useful feature. Individual search sets are based mainly on the taxonomic hierarchy but also include sequence tagged sites (STSs), expressed sequence tags (ESTs) and individual human chromosomes. NCGR is grateful to TimeLogic for its support in this effort, particularly TimeLogics contribution of one server for use by researchers. Please contact ncgr@ncgr.org if you have questions. Regards, Michael M. Harpold, Ph.D. Chief Scientific Officer .