From owner-biophys@hgmp.mrc.ac.uk Fri Jun 8 16:51:44 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A8A9217A61 for ; Fri, 8 Jun 2001 16:51:42 +0100 (BST) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C554E17AED for ; Fri, 8 Jun 2001 16:51:38 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C50F217B1B for ; Fri, 8 Jun 2001 16:51:29 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id QAA20797 for biophys-list@hgmp.mrc.ac.uk; Fri, 8 Jun 2001 16:47:58 +0100 (BST) X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: pkuzmic@biokin.com (Petr Kuzmic) X-Newsgroups: bionet.biophysics Subject: Available: Free software for kinetics and equilibria (DynaFit 3.25) Date: 8 Jun 2001 08:47:55 -0700 Organization: http://groups.google.com/ Lines: 41 Message-ID: <77754d4.0106080747.35ee6f1b@posting.google.com> Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 8bit X-Complaints-To: groups-support@google.com To: biophys@hgmp.mrc.ac.uk Sender: owner-biophys@hgmp.mrc.ac.uk Precedence: bulk The program DynaFit, free for academic researchers, was updated to version 3.25. This version features an option to output the computed initial reaction velocities at an arbitrary reaction time. The program is most useful in the analysis of complex reaction mechanism, for which traditional (algebraic) kinetic equations cannot be derived. See bibliography below for a list of 54 journal articles using DynaFit. EXAMPLE: "TIGHT BINDING" INHIBITION OF AN ENZYME DIMER ------------------------------------------------------- DYNAFIT INPUT [mechanism] Monomer + Monomer <==> Dimer : k1 k-1 Dimer + Inhibitor <==> Complex : k2 k-2 Dimer + Substrate <==> Intermediate : k3 k-3 Intermediate <==> Dimer + Product : k4 k-4 REFERENCES & LINKS ------------------------------------------------------- Home page http://www.biokin.com/dynafit/ Donwload http://www.biokin.com/dynafit/download.html User manual http://www.biokin.com/dynafit/scripting/ Bibliography http://www.biokin.com/dynafit/biblio.html Reference P. Kuzmic (1996) Anal. Biochem. 237, 260-273. Please contact me if you have any questions about installing or running the program. - P.K. ------------------------------------------------------- P e t r K u z m i c, Ph. D. * BioKin Ltd. 1652 S. Grand Ave. * Suite 337 * Pullman, WA 99163 509.334.4131 * 509.332.3493 fax * http://www.biokin.com .