From owner-metabolic-reg@net.bio.net Fri Jun 18 13:49:00 1999
Path: biosci!LAND.SUN.AC.ZA!JHSH
From: JHSH@LAND.SUN.AC.ZA ("Jannie Hofmeyr")
Newsgroups: bionet.metabolic-reg
Subject: Re: BSA vs. MCA
Date: 18 Jun 1999 07:49:28 -0700
Organization: Stellenbosch University
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Dear Michael

> It is true that various sensitivity coefficients can be obtained from
> experiment as Henrik described quite early in the development of MCA, but
> this is an emprical approach analogous to BSA. To link the control to
> specific molecular steps still requires knowledge of the kinetic
> mechanism. You've nicely described the relationship to simulation. My
> belief is that only MCA (or an analogous sensitivity analysis) is capable
> of providing lower-level insights.

I agree with you 100%. 

Jannie

Prof. Jannie Hofmeyr                   Tel:    +27 21 808 3039
Dept. of Biochemistry                  Fax:    +27 21 808 3022
University of Stellenbosch             e-mail: jhsh@maties.sun.ac.za
Private Bag X1
Matieland 7602
Stellenbosch
South Africa

.