From owner-celegans@net.bio.net Fri Jun 21 23:00:00 1996 Path: biosci!meiosis.wustl.edu!bwaterst From: bwaterst@meiosis.wustl.edu (Bob Waterston) Newsgroups: bionet.celegans Subject: Re: homologs, paralogs, orthologs Date: 22 Jun 1996 10:36:31 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 7 Sender: daemon@net.bio.net Distribution: world Message-ID: <9606221733.AA20438@watson.wustl.edu> References: <199606221643.JAA20212@net.bio.net> Reply-To: bwaterst@watson.wustl.edu NNTP-Posting-Host: net.bio.net Homologs are simply sequences related by descent. In gene families, orthologs represent the equivalent family member across species. This is best confirmed by conserved syntenic relationships with surrounding genes. Paralogs are gene family members across species, not thought to be orthologs. Bob Waterston .