From owner-bionews@hgmp.mrc.ac.uk Thu Nov 28 01:23:37 2002 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id 23FD47D134 for ; Thu, 28 Nov 2002 01:23:37 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 8CF567D0C3 for ; Thu, 28 Nov 2002 01:23:36 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6022) id 528DB7D105; Thu, 28 Nov 2002 01:23:35 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id E7B587D27B for ; Wed, 27 Nov 2002 14:12:43 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 2D1F07D274 for ; Wed, 27 Nov 2002 14:12:43 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id OAA04130 for bionet-announce@net.bio.net; Wed, 27 Nov 2002 14:12:42 GMT To: bionet-announce@net.bio.net From: Sam Griffiths-Jones Newsgroups: bionet.announce,bionet.software Subject: Rfam database of RNA families Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Trace: niobium.hgmp.mrc.ac.uk 1038406362 4128 193.62.207.221 (27 Nov 2002 14:12:42 GMT) X-Complaints-To: news@net.bio.net NNTP-Posting-Date: Wed, 27 Nov 2002 14:12:42 +0000 (UTC) Date: Thu, 28 Nov 2002 01:23:35 +0000 (GMT) Sender: owner-bionews@hgmp.mrc.ac.uk Precedence: bulk Rfam: A new database of multiple alignments and covariance models of non-coding RNA families -------------------------------------------------------------------- Rfam is a database of structure-annotated multiple sequence alignments, covariance models and family annotation for a number of non-coding RNA families. Rfam 2.0 contains 30 such families. The seed alignments are hand curated and aligned using available data, and covariance models are built from these alignments using the INFERNAL 0.52 software suite (http://infernal.wustl.edu/). The full alignments are created by searching a subset of the EMBL nucleotide database using the covariance model, and then aligning all hits above a family specific threshold to the model. Rfam 2.0 annotates 65072 regions in the EMBL database. Rfam is available on the web at the following URLs: http://www.sanger.ac.uk/Software/Rfam/ http://rfam.wustl.edu/ The database is also available for download in flatfile format from: ftp://ftp.sanger.ac.uk/pub/databases/Rfam/ ftp://ftp.genetics.wustl.edu/pub/eddy/Rfam/ For local searching the INFERNAL package is also required: http://infernal.wustl.edu/ Rfam is maintained by a consortium of researchers at the Wellcome Trust Sanger Institute, Cambridge, UK, and Washington University, St. Louis, USA. ----------------------------------- November 2002 - The Rfam Consortium .