From owner-bionews@hgmp.mrc.ac.uk Thu Mar 9 21:05:46 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id C581F17AF0; Thu, 9 Mar 2000 21:05:42 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id CB1B117AEF; Thu, 9 Mar 2000 21:05:39 +0000 (GMT) To: bionews@net.bio.net Newsgroups: bionet.announce Date: 9 Mar 2000 15:26:52 -0000 From: meetings@cshl.org (CSHL Meetings & Course Office) Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Subject: Genetic-Epidemiological Studies of Complex Diseases CSHL Message-Id: <20000309210539.CB1B117AEF@mercury.hgmp.mrc.ac.uk> Sender: owner-bionews@hgmp.mrc.ac.uk Precedence: bulk Cold Spring Harbor Course Genetic-Epidemiological Studies of Complex Diseases June 7 - 13, 2000 Instructors: Neil Risch, Stanford University Elizabeth Squires-Wheeler, Columbia University College of Physicians & Surgeons This lecture course will consider the difficulties in studying the genetic basis of complex disorders, such as diabetes, cardiovascular disease, cancer, Alzheimer's disease, schizophrenia and epilepsy, with a particular emphasis on neuropsychiatric conditions. We will discuss genetic-epidemiologic study designs, including family, twin and adoption studies, as well as mode of inheritance analyses, and their role in setting the framework for understanding the genetic and non-genetic components of a disease. A major focus will be the identification of specific gene effects using both linkage and association analysis. We will discuss the efficiency and robustness of different designs for such analysis; further we will consider how evidence from genetic-epidemiologic studies informs both the design and interpretation of molecular genetic studies. Recent discoveries of genes for both Mendelian and non-Mendelian diseases will guide the discussion of the various methodologic issues. We look forward to seeing you at Cold Spring Harbor. Apply online at http://www.cshl.org/meetings .