From owner-cellbiol@net.bio.net Tue Feb 04 22:00:00 1997 Path: biosci!agate!spool.mu.edu!uwm.edu!newsfeeds.sol.net!feed1.news.erols.com!news.bbnplanet.com!cpk-news-hub1.bbnplanet.com!mindspring!psinntp!news.intercon.com!news5.digex.net!haven.umd.edu!purdue!mozo.cc.purdue.edu!news From: "Matthew L. Bilodeau" Newsgroups: bionet.cellbiol Subject: Re: functions of histones?? Date: Wed, 05 Feb 1997 09:12:13 -0600 Organization: Purdue University Lines: 22 Message-ID: <32F8A34B.6BE2@biochem.purdue.edu> References: <01bc1356$b5307be0$LocalHost@default> Reply-To: bilodeau@biochem.purdue.edu NNTP-Posting-Host: bms12.vet.purdue.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0Gold (Macintosh; I; 68K) 4Ts wrote: > > anyine know the functions of the histones proteins?? apart from sticking > DNA together to form chromosome?? There is much recent research on histone function as a regulator of transcription. Some histone/chromatin modifying proteins which seem to be linked to this role include SNF/SWI (yeast; apparently important in the assembly and modification of the nucloesome), GCN5 (yeast; a histone acetyltransferase) and P/CAF and p300/CBP (CREB Binding Protein) (higher eukaryotes; histone acetyltransferases, the latter of which has been shown to be active on the four core histones). I hope this helps...MLB -- Matthew L. Bilodeau bilodeau@biochem.purdue.edu Dept. of Basic Medical Sciences Phone (317) 494-6448 West Lafayette, Indiana 47907 Fax (317) 494-0781 Doctor of Medicine (M.D.)/Doctor of Philosophy (Ph.D.) Program Indiana U. School of Medicine--Purdue U. Graduate School http://www.vet.purdue.edu/depts/lcme/index.html http://www.vet.purdue.edu/depts/bms/index.htm .