From owner-metabolic-reg@net.bio.net Mon Aug 05 23:00:00 1996
Path: biosci!daresbury!not-for-mail
From: "Stefan Schuster" <stefan=schuster@rz.hu-berlin.de>
Newsgroups: bionet.metabolic-reg
Subject: re: S=Km assumption
Date: 6 Aug 1996 10:56:15 +0100
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Although it does not contain a survey of experimental data, the following 
paper might be interesting in the context of the S=Km assumption:

R. Heinrich and E. Hoffmann: Kinetic Parameters of Enzymatic Reactions in 
States of Maximal Activity; An Evolutionary Approach. J. theor. Biol. 151 
(1991) 249-283. It gives a theoretical explanation of why this matching of 
substrate concentration and Michaelis constant is physiologically 
advantageous in the sense of catalytic efficiency.

An interrelation between the S to Km matching and the usage of normalized 
control coefficients was pointed out in 
S. Schuster and R. Heinrich: The Definitions of Metabolic Control Analysis 
Revisited. BioSystems 27 (1992) 1-15.

Stefan Schuster (Berlin)

.