From owner-metabolic-reg@net.bio.net Wed Nov 06 22:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!netnews.com!ix.netcom.com!news From: bellew@ix.netcom.com (Leo Bellew) Newsgroups: bionet.biology.cardiovascular,bionet.metabolic-reg,bionet.molbio.ageing,bionet.molbio.evolution,bionet.molbio.proteins,bionet.molecules.peptides,bionet.neuroscience Subject: Re: Physiologic Application of Molecular Biology Date: Thu, 07 Nov 1996 02:52:47 GMT Organization: Netcom Lines: 43 Message-ID: <32824be3.49540134@nntp.ix.netcom.com> References: Reply-To: bellew@ix.netcom.com NNTP-Posting-Host: phi-pa11-56.ix.netcom.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-NETCOM-Date: Wed Nov 06 6:56:03 PM PST 1996 X-Newsreader: Forte Agent .99f/32.299 Xref: biosci bionet.biology.cardiovascular:1267 bionet.metabolic-reg:870 bionet.molbio.ageing:3037 bionet.molbio.evolution:5290 bionet.molbio.proteins:9210 bionet.molecules.peptides:497 bionet.neuroscience:16596 I have been the architect or chief engineer on many high-tech computer software projects over the last 30 years where we have developed computer models of reality in many different situations utilizing engineering devices borrowed from areas such as artificial language and automata theory. I am very interested in the potential for utilizing these technologies in mapping the human genome to physiological function. In your note, you seem to imply that the relationships are known, at least in respect to the physiology techniques the course would be devoted to. Can you tell me if the problem of relating the human genome to physiological function is largely solved, and what formal mental, mathematical or simulative models provide the loci for that solution. Leo Bellew On 5 Nov 1996 16:38:08 -0800, David Stepp wrote: > >Many of us spend our days (and nights!) cloning, expressing and/or >knocking out genes that interest us. Often times, however, we are too >deep in the trees and lose sight of what our gene's function is in the >context of a whole animal or even at the organ level. I would be >interested to know what level of enthusiasm there is out there for >studying the physiology of your favorite gene. If you are overexpressing >a transcription factor that regulates cardiac gene expression, for >example, what effect does this have on cardiac performance, blood >pressure etc.? > >Granting agencies are asking for more than molecular biology these days; >they want relevance to a physiological or pathophysiological process. >Within this context, would you be interested in learning physiology >techniques (blood pressure measurements, cardiac and smooth contractility, >shear stress, electrophysiology etc) in a 2-3 week course as a means of >broadening your knowledge base and enhancing your experimental research?? > >Please forward your thoughts and comments to jmiano@post.its.mcw.edu. > >Thanks in advance! > > >Joe Miano & David W. Stepp .