From owner-bionews@hgmp.mrc.ac.uk Wed May 14 03:31:24 2003 Return-Path: X-Original-To: bionews-outgoing Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id D3C137D32E for ; Wed, 14 May 2003 03:31:23 +0100 (BST) X-Original-To: bionews-list@hgmp.mrc.ac.uk Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 5E67B7D0DB for ; Wed, 14 May 2003 03:31:23 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6022) id 2C1DC7D32E; Wed, 14 May 2003 03:31:22 +0100 (BST) X-Original-To: bionet-announce@net.bio.net Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 5773D7D1F1 for ; Sun, 11 May 2003 18:44:33 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 49A987D17F for ; Sun, 11 May 2003 18:44:32 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.11.6+Sun/8.8.8) id h4BHiVF03102 for bionet-announce@net.bio.net; Sun, 11 May 2003 18:44:31 +0100 (BST) To: bionet-announce@net.bio.net From: Sam Griffiths-Jones Newsgroups: bionet.announce,bionet.software Subject: Rfam 4.0 - a database of RNA families Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Trace: niobium.hgmp.mrc.ac.uk 1052675071 3100 193.62.207.221 (11 May 2003 17:44:31 GMT) X-Complaints-To: news@net.bio.net NNTP-Posting-Date: Sun, 11 May 2003 17:44:31 +0000 (UTC) X-X-Sender: sgj@pfam1a.internal.sanger.ac.uk Date: Wed, 14 May 2003 03:31:22 +0100 (BST) Sender: owner-bionews@hgmp.mrc.ac.uk Precedence: bulk Rfam: A database of multiple alignments and covariance models of non-coding RNA families ---------------------------------------------------------------- Rfam is a database of structure-annotated multiple sequence alignments, covariance models and family annotation for a number of non-coding RNA families. Rfam 4.0 contains 114 such families. The seed alignments are hand curated and aligned using available data, and covariance models are built from these alignments using the INFERNAL 0.55 software suite (http://infernal.wustl.edu/). The full alignments are created by searching a subset of the EMBL nucleotide database using the covariance model, and then aligning all hits above a family specific threshold to the model. Rfam 4.0 annotates 113613 regions in the EMBL database. Rfam is available on the web at the following URLs: http://www.sanger.ac.uk/Software/Rfam/ http://rfam.wustl.edu/ The database is also available for download in flatfile format from: ftp://ftp.sanger.ac.uk/pub/databases/Rfam/ ftp://ftp.genetics.wustl.edu/pub/eddy/Rfam/ For local searching the INFERNAL package is also required: http://infernal.wustl.edu/ Rfam is maintained by a consortium of researchers at the Wellcome Trust Sanger Institute, Cambridge, UK, and Washington University, St. Louis, USA. ------------------------------ May 2003 - The Rfam Consortium .