From owner-biophysics@net.bio.net Mon Oct 12 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!newsfeed.cwix.com!206.172.150.11!news1.bellglobal.com!torn!nott!nrccsb2.di.nrc.ca!kringle.bri.nrc.ca!yizhu From: Yi Zhu Newsgroups: bionet.biophysics Subject: NMR Postdoctoral Positions Date: Tue, 13 Oct 1998 16:02:09 -0400 Organization: National Research Council of Canada Lines: 64 Message-ID: NNTP-Posting-Host: kringle.bri.nrc.ca Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Two NMR Postdoctoral Positions: (available after January, 1999) (1) Solution Structure and Conformational Stability of Protein-Ligand Complexes (2) Conformational Dynamics of Bioactive Peptides The Biomolecular NMR laboratory of the Biotechnology Research Institute (BRI) has two postdoctoral openings in Biomolecular NMR. The first position will have the work centered on NOE assignment/structure calculations, NMR relaxation measurements, and meaurements of ligand exchange rates. The second position will focus on peptide conformational analysis, measurement of proton relaxation rates, and NMR-based conformational searches. Ideal candidates should have a recent Ph.D. in chemistry, biochemistry or a related discipline, and have prior experience in at least one or two areas of the planned research projects. The mandate of the Biomolecular NMR Group at BRI is to carry out research into the structure, molecular interactions and design of mimetics within protein systems that are strategic targets for pharmaceutical development. The core of our work is the use of multi-dimensional NMR to determine the bioactive conformations of peptides and protein fragments and to establish their modes of binding with protein targets. Research projects are focused on the following areas: (1) dissection of regulatory protease-inhibitor/cofactor functional interfaces; (2) minimization and mimetics design of the EGF- and granulin-like protein repeats; (3) interactions of kinase and phosphatase domains with their protein targets; (4) solution conformations of human parathyroid hormone (PTH) and antibody (VH) fragments; (5) methods for the structural characterization of protein-ligand complexes. The primary goal of our research is to elucidate the molecular determinants of the selective interactions of bioactive peptides and proteins and to assist the design of functional mimetics of protein-protein interactions. Our NMR work is supported by a 500 MHz NMR spectrometer and by shared use with external clients of a second 500 MHz NMR spectrometer and of an 800 MHz very-high-field NMR facility (established in 1997). The salary for postdoctoral fellows is at the standard MRC rate of CND$ 24,000-27,000/year commensurate with experience. Successful candidates are encouraged to apply for the NSERC visiting fellowships in NRC laboratories which offer a competitive salary of $36,000/year plus some relocation expenses. Interested candidates should send their CVs and arrange for two letters of references sent to: Dr. Feng Ni Group Leader, Biomolecular NMR Biotechnology Research Institute 6100 Royalmount Avenue Montreal, Quebec Canada H4P 2R2 or contact Dr. Feng Ni at: Phone: (514)-496-6729; Fax: (514)-496-5143 e_mail: Feng.Ni@nrc.ca .