From owner-dros@hgmp.mrc.ac.uk Wed Sep 13 17:52:33 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id A932617B8B; Wed, 13 Sep 2000 17:52:31 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6020) id E981917B8C; Wed, 13 Sep 2000 17:52:29 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 60001) id F376A17B49; Wed, 13 Sep 2000 15:57:29 +0100 (BST) To: bionet-drosophila@net.bio.net From: beitel@northwestern.edu (Greg Beitel) Newsgroups: bionet.drosophila Subject: Postdoctoral position open, Chicago area Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: Mime-Version: 1.0 Content-Type: text/plain; charset="us-ascii" ; format="flowed" X-Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6024) id 18F8917A85; Wed, 13 Sep 2000 15:57:27 +0100 (BST) X-Received: from lulu.it.northwestern.edu (lulu.acns.nwu.edu [129.105.16.54]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id DC706415DC for ; Wed, 13 Sep 2000 15:57:26 +0100 (BST) X-Received: (from mailnull@localhost) by lulu.it.northwestern.edu (8.8.7/8.8.7) id JAA25411 for ; Wed, 13 Sep 2000 09:57:26 -0500 (CDT) X-Received: from [129.105.41.214] (beitellab1.bmbcb.nwu.edu [129.105.41.214]) by lulu.acns.nwu.edu via smap (V2.0) id xma025030; Wed, 13 Sep 00 09:55:57 -0500 X-Sender: gjb871@lulu.it.northwestern.edu X-To: dros@net.bio.net Date: Wed, 13 Sep 2000 17:52:29 +0100 (BST) Sender: owner-dros@hgmp.mrc.ac.uk Precedence: bulk Postdoctoral Position Available: Drosophila Tracheal Development at Northwestern university Lab: Dr. Greg Beitel, BMBCB Hogan Hall Rm. 2-100, Northwestern University, Evanston IL 60208-3500; (847) 467-7776, beitel@northwestern.edu Research area Our laboratory's long term goal is to understand how individual cells control their shapes and coordinate with other cells to create the complex organs found in multicellular organisms. To this end, we are using genetic, molecular and cell biological approaches to identify and study genes required for the morphogenesis of the Drosophila tracheal system. The Drosophila tracheal system is a ramifying network of epithelial tubes that serves as a combined airway and vascular system for delivering oxygen to tissues in the fly. At the molecular level, Drosophila tracheal development has striking similarities to both vertebrate lung and vascular development. These similarities, coupled with the simplicity of the tracheal system and the power of Drosophila genetics, makes the tracheal system an outstanding model system for understanding the morphogenesis of the tubular epithelia that are central to such vertebrate organs as the vascular system, lung and kidney. We have shown that size of the Drosophila tracheal tubes is controlled by a genetic program and identified mutations in eight genes that cause the tracheal tubes to have abnormal lengths or diameters (Beitel and Krasnow, Development 2000, 127 p.3271-3282: http://usa.biologists.com/Development/127/15/dev7811.html). We have also identified mutations that affect cell-cell adhesion and the apical/basal organization of tracheal cells. We are currently cloning and characterizing several of these genes, and will pursue their vertebrate homologues to understand the general roles of these genes in the morphogenesis of tubular epithelial organs. Job description Responsibilities of this position include: Performing molecular biology experiments (cloning, PCR, Southern blotting using radionucleotides) as outlined by the PI; performing Drosophila genetic experiments (crosses, phenotypic analysis) as outlined by the PI (previous experience with Drosophila or other genetic organism preferred but not essential); maintaining lab Drosophila stocks; keeping detailed and accurate records of procedures and data; presenting experimental results at lab meetings; maintaining general laboratory records, inventories, ordering and tracking grant expenditures; assisting in supervising and training undergraduates. Position requires a Bachelors degree in Biology or related field. The research objective is to understand how epithelial cells control their shapes to create and regulate the size of tubes in organs such as the circulatory system, lung and kidney. Dr. Greg Beitel, Assistant Professor Dept. of Biochemistry, Molecular Biology and Cell Biology (BMBCB) Hogan Hall, Rm. 2-100 2153 North Campus Dr. Northwestern University Evanston, IL 60208-3500 U.S.A. Phone: (847) 467-7776 FAX: (847) 467-1380 --- .