From owner-metabolic-reg@net.bio.net Mon Jan 10 22:00:00 1994 Path: biosci!daresbury!not-for-mail From: "" Newsgroups: bionet.metabolic-reg Subject: Re: sources on various Keq values? Date: 11 Jan 1994 17:59:32 -0000 Lines: 19 Sender: daemon@mserv1.dl.ac.uk Distribution: bionet Message-ID: <2gupe4$idp@mserv1.dl.ac.uk> Original-To: btk-mca@net.bio.net In <9401111729.AA09031@net.bio.net> mroussel@alchemy.chem.utoronto.ca (Marc Roussel) writes: > There are few tables of equilibrium constants. Instead, use tables >of Gibbs free energies of formation. [snip] A single enzyme is capable of taking a reaction essentially to completion, far from thermodynamic equilibrium. If the enzymes for both a forward and reverse reaction are operating simultaneously, then one can expect a steady state, or "dynamic equilibrium" to be achieved, but is this necessarily the same as the thermodynamic equilibrium? Won't it be changed by changing the relative amounts of the forward and reverse enzyme? (At the limit when one of the two is completely removed, one should return to the essentially irreversible case.) And if this is true, how applicable is the thermodynamic equil. constant to computing the relative levels of the compunds *in vivo*? Paul schlosser@beta.ciit.org .