From owner-celegans@net.bio.net Tue Oct 26 16:09:00 1999 Path: biosci!biosci!not-for-mail From: Colin Dolphin Newsgroups: bionet.celegans Subject: Postdoctoral position at Kings College London Date: 26 Oct 1999 10:09:31 -0700 Organization: Kings College London Lines: 26 Sender: daemon@net.bio.net Approved: wmorgan@acs.wooster.edu Distribution: world Message-ID: <7v4n8b$12n@net.bio.net> NNTP-Posting-Host: net.bio.net Postdoctoral position - King's College London A 3-year Wellcome Trust-funded postdoctoral position is available to investigate the neurobiological role(s) of flavin-monooxygenase (FMO) enzymes in C. elegans. In humans, loss of function mutations in the FMO3 gene underly the inherited metabolic disorder "fish-odour syndrome" in which affected individuals are unable to metabolise dietary-derived trimethylamine resulting in a distinctive body malodour (Nature Genetics 17, 491-494.). However, there is also significant evidence to indicate a physiological role(s) for these enzymes perhaps involving biogenic amine homeostasis. Four apparent Fmo gene homologues have been identified in C. elegans and it is the objective of the proposed project to gain insight into the physiological role(s) of FMO by studying the functions of these genes in C. elegans using both biochemical and reverse genetic approaches. Candidates should have a strong background in molecular genetics, be familiar with C. elegans research and, preferably, with ACEDB. King's College is situated next to the South Bank art and theatre complex and close to the West End. If interested please send CV, a brief summary of research experience and the names of three referees to: Colin Dolphin, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA. e-mail colin.dolphin@kcl.ac.uk .