From owner-celegans@hgmp.mrc.ac.uk Mon Apr 17 18:00:18 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 4C41D17ADA; Mon, 17 Apr 2000 18:00:09 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id EF9B517ADA; Mon, 17 Apr 2000 18:00:03 +0100 (BST) To: celegans@net.bio.net Newsgroups: bionet.celegans Date: Mon, 17 Apr 2000 08:36:07 +0100 From: c.watts@garvan.unsw.edu.au (Charles Watts) Subject: Request for collaborator: potential tumor suppressor gene Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-Id: <20000417170003.EF9B517ADA@mercury.hgmp.mrc.ac.uk> Sender: owner-celegans@hgmp.mrc.ac.uk Precedence: bulk Can I interest anyone of you worm experts in a collaboration to assist in defining the role of a putative tumor suppressor gene? We recently cloned EDD (Callaghan et al Oncogene 1998, 17: 3479-3491), the human homolog of the developmentally important Drosophila tumor suppressor gene 'hyperplastic discs' for which some biology is known (Mansfield et al Dev Biology 1994 165: 507-526). There is an apparent C. elegans homolog of 'hyperplastic discs' and EDD (F36A2.13)- a partial alignment is shown in our Oncogene paper, above. As far as I can tell, nothing has been done on the function of this gene in the worm although it is likely to be a ubiquitin protein ligase (HECT-domain family). Thanks Charles (c.watts@garvan.unsw.edu.au) --- .