From owner-metabolic-reg@net.bio.net Fri Oct 08 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!uknet!festival!castle.ed.ac.uk!eang62 From: eang62@castle.ed.ac.uk (Herbert Sauro) Newsgroups: bionet.metabolic-reg Subject: Re: Universal method (was: Re: Substance rather than form) Keywords: Kacser & Acerenza, EJB 216: 361-367 (1993) Message-ID: Date: 9 Oct 93 11:40:03 GMT References: Sender: news@festival.ed.ac.uk (remote news read deamon) Organization: University of Edinburgh Lines: 72 In article prm@aber.ac.uk (Pedro Mendes) writes: >eanv20@castle.ed.ac.uk (John Woods) wrote: > >>Substance: >>Kacser and Acerenza have recently published a `Universal method for >>achieving increases in metabolite production' [Eur. J. Biochem. >>216:361-367 (1993)]. So that's that, then. Better find a different > > {stuff about [Form: deleted} > >>And as it looks as if this is just a systematic application of the >>branchpoint theorem, Quite correct and understood by many of us involved in mca. >I don't know where you recosigned the branch point theorem in this paper. If >'branch point theorem' means 'the sum of the input fluxes is equal to the >sum of the output fluxes', this is just a consequence of the definition of a >steady state, it has nothing to do with control. Remember that this is about >LARGE changes, therefore completely outside the scope of MCA As an amateur - not by choice and virtually penniless in the process - it makes me feel ill to find professionals who are paid good money plus all research expenses paid for, making mistakes like this. The second law at work yet again..... I know I should be constructive here, but all I can say is read the literature. >Pedro Mendes >prm@aber.ac.uk > > Herbert Sauro. -------------------------------------------------------------------------- Excuse all this crap but it's to persuade the news reader that I've written a long message. So here goes erkfhjsdklfhsdkjfhsdkjhfsd fskdjfhsdkjhf ksjdfhskjdhfksjdhf sdfkjsdhf ksdfjhsdfkjsd hfksjdfhsdkj fsdkjfhsdkjfh sdkjfh sdkfjhsdjkfhs dfskdjfh sdfkjsdhf sdkjfhsdk fsdkjfhsdkj fsdkjfhsdkjfh sd sdfjhsdkjfhsd fskdjfhsdk fskdjhfsdkjf sdkjfhsdk fsdkjhfsdkjf sdkjfh df sdjkfhsdkjfh ksdjfhsdk jfksdjfh sdkfsdkjfhsd fksdjhfsdkjf hsdkjfhsd f sdkjfhsdkjfhsdkjf sdkjfhsdkjf hsdkjfhsd kfsdkjfhsdkjf hsdkjfhsdkjfsdhf sdkjfhsdkjfhs dfkjsdhfk sdjfhsdk fhsdkjfhsdk;jfhsd fksdkfjhsd kfsdhf sdkjfhsdkjf sdkfjhsdkj fsdkjfhsdkfj sdkjfhsdkjf hsdkfhjsdkfj hsdkjfhsdkjf h sdjkfhskjdfhsd fksdjfhsdk fjsdkjfhsdkj fsdkjfhs sdfs dfsdkjfhsd f sdkjfhsd fskdjfh sdfksjdfh sdkjfh sdkfjhsd fksdjhfksd jfhsdkjfhsdkjf hsdf ksdjhfksjdhf sdkfjhsdfk jsdkfjhsd kfsdkjfhsdkfjhdkfjshdfkjsdh fsdf kdjfhkjsdfh sdkfjhsdkjf sdkjfhsdk jfsdkjfhsdkjfh sekdjfhsdkj fsdkjfhsd kjf sdfjhsdkjfhsdkjfhs dfkjsdhf ksdfkjsdfh kjsd fsdkjfhsdkjfh sdkjfh sdkfjhsdjkfhs dfskdjfh sdfkjsdhf sdkjfhsdk fsdkjfhsdkj fsdkjfhsdkjfh sd sdfjhsdkjfhsd fskdjfhsdk fskdjhfsdkjf sdkjfhsdk fsdkjhfsdkjf sdkjfh df sdjkfhsdkjfh ksdjfhsdk jfksdjfh sdkfsdkjfhsd fksdjhfsdkjf hsdkjfhsd f sdkjfhsdkjfhsdkjf sdkjfhsdkjf hsdkjfhsd kfsdkjfhsdkjf hsdkjfhsdkjfsdhf sdkjfhsdkjfhs dfkjsdhfk sdjfhsdk fhsdkjfhsdk;jfhsd fksdkfjhsd kfsdhf sdkjfhsdkjf sdkfjhsdkj fsdkjfhsdkfj sdkjfhsdkjf hsdkfhjsdkfj hsdkjfhsdkjf h sdjkfhskjdfhsd fksdjfhsdk fjsdkjfhsdkj fsdkjfhs sdfs dfsdkjfhsd f sdkjfhsd fskdjfh fsdkjfhsdkjfh sdkjfh sdkfjhsdjkfhs dfskdjfh sdfkjsdhf sdkjfhsdk fsdkjfhsdkj fsdkjfhsdkjfh sd sdfjhsdkjfhsd fskdjfhsdk fskdjhfsdkjf sdkjfhsdk fsdkjhfsdkjf sdkjfh df sdjkfhsdkjfh ksdjfhsdk jfksdjfh sdkfsdkjfhsd fksdjhfsdkjf hsdkjfhsd f sdkjfhsdkjfhsdkjf sdkjfhsdkjf hsdkjfhsd kfsdkjfhsdkjf hsdkjfhsdkjfsdhf sdkjfhsdkjfhs dfkjsdhfk sdjfhsdk fhsdkjfhsdk;jfhsd fksdkfjhsd kfsdhf sdkjfhsdkjf sdkfjhsdkj fsdkjfhsdkfj sdkjfhsdkjf hsdkfhjsdkfj hsdkjfhsdkjf h sdjkfhskjdfhsd fksdjfhsdk fjsdkjfhsdkj fsdkjfhs sdfs dfsdkjfhsd f sdkjfhsd fskdjfh .