From owner-metabolic-reg@net.bio.net Sun Feb 27 22:00:00 1994 Path: biosci!ciit.org!SCHLOSSER From: SCHLOSSER@ciit.org (Paul Schlosser) Newsgroups: bionet.metabolic-reg Subject: re: RJ Jackson program Date: 28 Feb 1994 13:38:53 -0000 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 14 Sender: daemon@net.bio.net Distribution: bionet Message-ID: <199402281338.FAA12056@net.bio.net> NNTP-Posting-Host: net.bio.net Herbert asked me a few questions about the program; I'll answer them here. I'm pretty sure that it runs on DOS (IBM/clones). There's nothing wrong with calculating FCCs numerically, I do it all the time. I use a brute force [flux(param + d) - flux(param - d)]*param/(flux*d), and make sure that the result is not changed by an order of magnitude decrease in d. When I check this against matrix methods (with the elasticities calculated in the same way :-) ) the results are identical. I mentioned this in case there was a preferance for matrix methods. OK, I'll contact Dr. Jackson in the near future to ask about the program & if we can obtain some copies. Also documentation/refs. Paul .