From owner-dros@hgmp.mrc.ac.uk Tue Sep 12 17:06:11 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 1CB6B17AC6; Tue, 12 Sep 2000 17:06:11 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6020) id 6CDC217AA8; Tue, 12 Sep 2000 17:06:09 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 60001) id AF35217AD1; Mon, 11 Sep 2000 23:53:59 +0100 (BST) To: bionet-drosophila@net.bio.net From: hcerutti1@unl.edu (Heriberto Cerutti) Newsgroups: bionet.drosophila Subject: Postdoctoral Position: Epigenetic (Trans)Gene Silencing Organization: University of Nebraska-Lincoln Message-ID: <39BD1CBA.2183@unl.edu> MIME-Version: 1.0 Content-Transfer-Encoding: 7bit Content-Type: text/plain; charset=us-ascii X-Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6024) id 02AAB17ACF; Mon, 11 Sep 2000 23:53:57 +0100 (BST) X-Received: from unlnotes.unl.edu (unlnotes.unl.edu [129.93.1.131]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 3D3F0415D4 for ; Mon, 11 Sep 2000 23:53:57 +0100 (BST) X-Received: from 129.93.136.47 ([129.93.136.47]) by unlnotes.unl.edu (Lotus Domino Release 5.0.3) with SMTP id 2000091117531112:34555 ; Mon, 11 Sep 2000 17:53:11 -0500 X-Reply-To: hcerutti@unlnotes.unl.edu X-Mailer: Mozilla 3.0-C-AICK1-2 (Macintosh; U; PPC) X-To: dros@net.bio.net X-MIMETrack: Itemize by SMTP Server on UNLNOTES.UNL.EDU/Servers/UNEBR(Release 5.0.3 |March 21, 2000) at 09/11/2000 05:53:11 PM, Serialize by Router on UNLNOTES.UNL.EDU/Servers/UNEBR(Release 5.0.3 |March 21, 2000) at 09/11/2000 05:53:56 PM, Serialize complete at 09/11/2000 05:53:56 PM Date: Tue, 12 Sep 2000 17:06:09 +0100 (BST) Sender: owner-dros@hgmp.mrc.ac.uk Precedence: bulk Postdoctoral Position: Epigenetic (Trans)Gene Silencing An NSF-funded Postdoctoral position is available immediately to study the molecular mechanisms responsible for epigenetic (trans)gene silencing. In plants, transgenes are silenced at both transcriptional and post-transcriptional levels. Similar mechanisms appear to control the expression of transposable elements and might also be involved in the developmental regulation of gene expression. The project will entail functional genomic approaches, such as transposon-mediated insertional mutagenesis, for the isolation of genes involved in epigenetic silencing, the molecular characterization of the mutants, and the identification of interacting proteins by affinity purification/MS sequencing. Arabidopsis thaliana and the unicellular green alga Chlamydomonas reinhardtii are being used as model systems. We have recently cloned a novel DEAH-box RNA helicase that is required for transgene and transposon silencing in Chlamydomonas (Wu-Scharf et al., Science 290, in press [2000]). The successful candidate will have access to state-of-the-art facilities in the George W. Beadle Center for Genetics Research and acquire experience in chromatin analyses, proteomics, and functional genomics. A background in molecular genetics and biochemistry is desirable. Applicants should send a CV, statement of research experience, and three letters of reference to: Dr. Heriberto Cerutti, School of Biological Sciences, University of Nebraska-Lincoln, E211 Beadle Center, P.O. Box 880666, Lincoln, NE 68588-0666; phone (402) 472-0247; fax (402) 472-8722; e-mail hcerutti1@unl.edu. Review of applications will begin October 1, 2000, and will continue until a suitable candidate is found. UNL is committed to a pluralistic campus community through Affirmative Action and Equal Opportunity and assures reasonable accommodation under the Americans With Disabilities Act. --- .