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From: hines@pharm.med.upenn.edu (John Hines)
X-Newsgroups: bionet.metabolic-reg
Subject: in search of an insulin receptor antagonist
Date: Mon, 11 Jun 2001 16:29:52 -0400
Organization: University of Pennsylvania
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Is there such a thing?  I've never heard of one, although I am,
admittedly, very new to the area.  I've been able to stimulate the MAP
kinase pathway in a cell line by treating with insulin (1 uM).  However,
I'd feel more comfortable with the conclusion that there are functional
insulin receptors present if I could block the signaling with an
antagonist.

Only I've never heard of one.  Is there an antagonist for insulin receptors?
I'd be grateful for any information/insights.

(please reply to hines@pharm.med.upenn.edu)

John


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