From owner-biophysics@net.bio.net Mon Mar 21 22:00:00 1994
Path: biosci!parc!decwrl!decwrl!elroy.jpl.nasa.gov!swrinde!cs.utexas.edu!howland.reston.ans.net!usenet.ins.cwru.edu!cleveland.Freenet.Edu!dy684
From: dy684@cleveland.Freenet.Edu (Roberto Albinoni)
Newsgroups: bionet.molbio.proteins,bionet.biophysics
Subject: Equivalent amino acids for similarity searches
Date: 22 Mar 1994 09:57:13 GMT
Organization: Case Western Reserve University, Cleveland, OH (USA)
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Reply-To: dy684@cleveland.Freenet.Edu (Roberto Albinoni)
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Xref: biosci bionet.molbio.proteins:1597 bionet.biophysics:120


i am comparing the dna-derived amino acids sequences of two proteins in
order to determine which residues may be most important to enzymatic
function. 

i wonder if someone to point me to appropriate references on which amino
acids can be considered most similar based on their chemistry and function,
and also how one can 'score' the similarity of two proteins based not only
on identical residues, but also on amino acids which belong to the same
chemical families.

.