From owner-celegans@hgmp.mrc.ac.uk Mon Mar 20 14:48:02 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id B1D4217A7F; Mon, 20 Mar 2000 14:47:59 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id 76A9117A69; Mon, 20 Mar 2000 14:47:54 +0000 (GMT) To: celegans@net.bio.net Newsgroups: bionet.celegans Date: Mon, 20 Mar 2000 14:11:10 +0000 From: mark.blaxter@ed.ac.uk (Mark Blaxter) Subject: Postdoctoral position in Edinburgh: Nematode Genomics Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-Id: <20000320144754.76A9117A69@mercury.hgmp.mrc.ac.uk> Sender: owner-celegans@hgmp.mrc.ac.uk Precedence: bulk Dear Colleague I would be grateful if you could bring the following notice to anyone who may be interested. Thanks Mark Blaxter Postdoctoral Research Fellow in Edinburgh The Nematode EST Project Parasitic nematodes infect humans, animals and plants. They cause significant disease, morbidity and mortality, and are economically very damaging to the agricultural economies of developed and developing countries. The genome of the nematode Caenorhabditis elegans has been sequenced. About 40% of the identified genes cannot be identified by database search and appear to be C. elegans specific. Analysis of expressed sequence tags or ESTs of the human parasite Brugia malayi shows that many of these novel genes may in fact be nematode-specific. We suggest that work on other economically important nematodes can benefit directly from the C. elegans genome project and that full understanding of the C. elegans genome may only be achieved by comparison to other nematodes. We have been funded by the Wellcome Trust to generate ~20,000 ESTs each from five additional nematode species selected on the basis of their medical, economic and research importance (see http://www.ed.ac.uk/~mbx/small_genomes.html for more details). We are seeking a qualified molecular biologist with experience of cDNA library construction, and possibly also genomics or related disciplines. A familiarity with UNIX-based biocomputing will be an advantage. The appointee will be involved in cDNA library construction, clone selection and extensive sequence analysis. The bulk of the sequencing will be carried out in collaboration with the Sanger Centre, Cambridge. The post is for 24 months and is available immediately. A parallel project is being carried out in the USA under the direction of Dr. Jim McCarter (Washington University, St. Louis), and our programs are designed to dovetail closely. For background to the research please see the world wide web at http://www.ed.ac.uk/~mbx/small_genomes.html. Also of relevance are Blaxter, M. L. (1998). Caenorhabditis elegans is a nematode. Science 282, 2041-2046 Blaxter, M. L., et al (1999). Parasitic helminth genomics. Parasitology 118, S39-S51 Blaxter, M. L., et al (1996). Genes expressed in Brugia malayi infective third stage larvae. Molecular and Biochemical Parasitology 77, 77-96 Burglin, T., Lobos, E. & Blaxter, M. L. (1998). Caenorhabditis elegans as a model for parasitic nematodes. International Journal for Parasitology 28, 395-411 Enquiries to Dr Mark Blaxter by 12/04/00 email: Mark.Blaxter@ed.ac.uk tel. 0131 650 6760 Further particulars including details of the application procedure should be obtained from the Personnel Department, The University of Edinburgh, 9-16 Chambers Street, Edinburgh EH1 1HT or Tel: 0131-650-2511 (24 hour answering service). Please quote ref: 306053WW. posted to email 20/03/00 _________________________________________________ Dr. Mark Blaxter email Mark.Blaxter@ed.ac.uk Institute of Cell, Animal and Population Biology Ashworth laboratories, Room 311 King's Buildings, University of Edinburgh, West Mains Road, EDINBURGH EH9 3JT, UK phone: (+44) 131 650 6760 Fax :...650 5450 see http://www.ed.ac.uk/~mbx/blaxlab.html ~ may all beings be happy ~ --- .