From owner-biophysics@net.bio.net Mon Feb 28 22:00:00 1994
Path: biosci!MBIMAIL.UMD.EDU!collins
From: collins@MBIMAIL.UMD.EDU (John Collins)
Newsgroups: bionet.biophysics
Subject: Re: Ca-blocking toxins
Date: 1 Mar 1994 02:05:21 -0000
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 14
Sender: daemon@net.bio.net
Distribution: bionet
Message-ID: <9402282057.A09720@mbimail.umd.edu>
NNTP-Posting-Host: net.bio.net

HAve you tried ryanodine to block intracellular Ca2+ release?
(This would assume that you have brain-type ryanodine receptors in
your snail neurons.)
There are also a couple of scorpion venom toxins (from B. hotentota)
that either block or activate the ryanodine receptor of skeletal muscle,
and I think also affect the cardiac and brain isoforms.

I'm interested in structure-function relationships of ion channel-blocking
 scorpion toxins.  What more can you tell me about the above-mentioned toxins?

 John Collins
 Univ. MD, Baltimore
 collins@mbimail.ab.umd.edu


.