From owner-btk-mca@hgmp.mrc.ac.uk Sun Jun 11 15:21:07 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 45CF417AB1; Sun, 11 Jun 2000 15:21:06 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 6024) id B5BA017AAE; Sun, 11 Jun 2000 15:21:03 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id D1122415D5 for ; Sun, 11 Jun 2000 15:21:02 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id PAA11378 for btk-mca-list@hgmp.mrc.ac.uk; Sun, 11 Jun 2000 15:21:02 +0100 (BST) X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "Herbert M Sauro" X-Newsgroups: bionet.metabolic-reg Subject: Re: Perfect enzymes (WAS: Phosphofructokinase controls...) Date: Sun, 11 Jun 2000 15:16:39 +0100 Message-ID: <960733206.12407.0.nnrp-14.c2de3927@news.demon.co.uk> References: <3941010C.55F085AB@biokin.com> X-NNTP-Posting-Host: fssc.demon.co.uk:194.222.57.39 X-Trace: news.demon.co.uk 960733206 nnrp-14:12407 NO-IDENT fssc.demon.co.uk:194.222.57.39 X-Complaints-To: abuse@demon.net X-Priority: 3 X-MSMail-Priority: Normal X-Newsreader: Microsoft Outlook Express 5.00.2314.1300 X-MimeOLE: Produced By Microsoft MimeOLE V5.00.2314.1300 Lines: 20 To: btk-mca@hgmp.mrc.ac.uk Sender: owner-btk-mca@hgmp.mrc.ac.uk Precedence: bulk Petr Kuzmic wrote in message news:3941010C.55F085AB@biokin.com... > This is especially > true for the Rational Drug Design movement in the 1980s, when people > tried to manufacture pharmaceutically effective inhibitors as purported > analogs of the elusive "transition state structure". I think it is > important that this was once perceived as one of the leading > methodologies in a multi-billion dollar industry. > > -- Petr I guess there is a lesson there for all of us. Herbert Sauro .