From owner-metabolic-reg@net.bio.net Wed Nov 13 22:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!surfnet.nl!swidir.switch.ch!swsbe6.switch.ch!news.belnet.be!news.fundp.ac.be!chokotoff.biocell.fundp.ac.be!user From: oltou@biocell.fundp.ac.be (Olivier TOUSSAINT) Newsgroups: bionet.metabolic-reg Subject: Re: Any thoughts? Date: Thu, 14 Nov 1996 18:30:54 +0100 Organization: F.U.N.D.P - Cellular Biochemistry Lines: 21 Distribution: world Message-ID: References: NNTP-Posting-Host: chokotoff.biocell.fundp.ac.be you should contact Hans Werterhof (or Westerhoff) in Amsterdam (The Netherlands). He's a world specialist in this field In article (Dans l'article) , dsul@HELIX.NIH.GOV (Daniel M. Sullivan) wrote (écrivait) : > I have only recently learned of metabolic control analysis but I find it > very interesting. Being a pharmacologist by training I was wondering if > anybody has considered signal transduction pathways as a special case of > metabolic control. These pathways are very tightly controlled and capable > of inducing massive changes in the concentration of a single metabolite. > Can this be accomplished simply by regulating an enzyme with a control > coefficient very close to 1, or is there more to the story. If not, is > there something to be learned about more subtle changes in metabolic > pathways by studying this relatively simple case. Any thoughts? > > Daniel M. Sullivan, Ph.D. > NEI/NIH - Lab of Immunology > Section on Ocular Gene Therapy > Bldg 10 Room 10N202 > 9000 Rockville Pk. .