From owner-biophysics@net.bio.net Mon Jan 25 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Kathy King" 01/26 4:55 PM >>> Newsgroups: bionet.prof-society.biophysics Subject: Ligand Recognition and Molecular Gating Date: 26 Jan 1999 14:15:34 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 97 Sender: daemon@net.bio.net Approved: kking@biophysics.faseb.org Distribution: world Message-ID: <78leq6$h14@net.bio.net> NNTP-Posting-Host: net.bio.net Gordon Research Conference on: Ligand Recognition and Molecular Gating http://www.grc.uri.edu/programs/1999/ligand.htm Ventura, CA March 7-12, 1999 Chair: Thue W. Schwartz Vice chair: Diane M. Papazian Session 1: (Sunday p.m.) Topic: New 3D Structures of Membrane Proteins * Doug Rees: X-ray structure of a pentameric mechanosensitive channel from M. tuberculosis. * Speaker to be announced: Another braking and exciting 3D news story * Y.Fujiyoshi: Aquaporin and other membrane proteins studied by helium temp EM ________________________________________________________________ Session 2: (Monday a.m.) Topic: Multiple Molecular Mechanisms of Gating (Wayne Hubbell) * Eduardo Perozo: Structural rearrangements in proton-dependent K+ channel gating. * Pancho Bezanilla: Molecular mechanism of voltage gating in K+ channels. * Horst Vogel: Probing single ligand-gated ion channel molecules by combined electrical and optical measurements. * Peter Agre: Molecular mechanism of gating in aquaporins * David Julius: Capsaisin receptor and heat activated channels. ___________________________ Session 3: (Monday p.m.) Topic: Translocation and Solubilization of Proteins - in and out of Membranes * Alan Finkelstein: Protein translocation associated with voltage gating of toxin channels. * Harry Haigler: Soluble annexin forms transmembrane channel by reversible "inside-out" refolding. * Jean-Luc Popot: Amphipols: how to handle integral membrane proteins in detergent-free aqueous solutions'. ____________________________________________________ Session 4: (Tuesday a.m.) Topic: Protein-Protein Interactions in the Membrane (Don Engelman) * Don Engelman: Helix interactions in vivo - better physical chemistry through genetics. * John Spudich: A 7-helix phototaxis receptor - conformational changes couple signaling to a co-receptor. * Fiona Marshall: Surface expression of 7TM receptors through 1TM-7TM and 7TM-7TM heterodimerization. * Mark Lemon: Ligand-induced homo- and hetero-dimerization of growth factor receptor tyrosine kinases. ___________________________ Session 5: (Tuesday p.m.) Topic: Forces and Principles in Ligand Recognition (Barry Honig) * Barry Honig: Principles and forces of ligand recognition * Jim A.Wells: Molecular recognition at protein interfaces * Christian Elling: Metal-ion mediated ligand binding - 7TM receptor activation. __________________________________________________________________ Session 6: (Wedensday a.m.) Topic: $-barrel Membrane Proteins (Tilman Schirmer) * Tilman Schirmer: Selective versus non-selective porins * Jeremy Lakey: Ligand induced gating of OmpF porin beta-barrel ion channels * Susan Buchanan: The ferric enterobactin receptor - a beta-barrel active transporter * Kaspar Locher: Structure of the hydroximate receptor FhuA in its apo and holo form. ___________________________ Session 7: (Wedensday p.m.) Topic: Transporters - Recognition and Gating (Ron Kaback) * Michael P. Kavanaugh: Glutamate transport - as viewed form both the ligand and the transporter. * Ron Kaback: What to do while waiting for your protein to crystalize! * Shimon Schuldiner: Structure & function of the multidrug resistence pump EmrE _______________________________________________________________ Session 8: (Thursday a.m.) Topic: Conformational Changes & ligand binding in 7TM receptor (Gebhard Schertler) * Gebhard Schertler: Structure of bovine rhodopsin obtained by cryo-microscopy: a first view of an inverse agonist bound to a G-protein couple receptor * Wayne Hubbell: Rhodopsin - conformational changes of activation probed by EPR * Jean-Luc Galzi: Simultaneous time-resolved recording of signaling and ligand-binding by FRET in 7TM's * Falk Fahrenholtz: Cholesterol / steroid dependency of certain 7TMs * Bruce Conklin: Controlled in vivo ligand recognition of 7TM's in transgenic mice __________________________________________________________________ Session 9: (Thursday p.m.) Topic: De novo Design and Recognition in Membrane Proteins (Bill DeGrado) * Bill Degrado: De Novo design of membrane proteins * Hagan Bayley: Redesign of alpha-hemolysin - ligand recognition / bioprobe * Gerd Koechendorfer: Organic Synthetic approach to membrane proteins .