From owner-biophys@hgmp.mrc.ac.uk Thu Aug 1 15:12:16 2002 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id BE00117AA1 for ; Thu, 1 Aug 2002 15:12:15 +0100 (BST) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 4543F17BE5 for ; Thu, 1 Aug 2002 15:12:14 +0100 (BST) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 0058017AA1 for ; Thu, 1 Aug 2002 15:12:11 +0100 (BST) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id PAA05559 for biophys-list@hgmp.mrc.ac.uk; Thu, 1 Aug 2002 15:12:11 +0100 (BST) X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: a.van.ooyen@nih.knaw.nl (Arjen van Ooyen) X-Newsgroups: bionet.biophysics Subject: New Paper: Firing Patterns and Dendritic Topology Date: 1 Aug 2002 15:12:10 +0100 Organization: Netherlands Institute for Brain Research Lines: 45 Message-ID: <3D49414C.9402B8B6@nih.knaw.nl> Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 9B15E17D99 for ; Thu, 1 Aug 2002 15:12:08 +0100 (BST) X-Received: from ns1.ioi.knaw.nl (ns1.ioi.knaw.nl [194.171.152.2]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 5542717BE5 for ; Thu, 1 Aug 2002 15:12:06 +0100 (BST) X-Received: from nih.knaw.nl (nibr189.nih.knaw.nl [192.87.10.131]) by ns1.ioi.knaw.nl (8.9.3/8.9.3) with ESMTP id QAA21851 for ; Thu, 1 Aug 2002 16:12:05 +0200 (MET DST) X-Mailer: Mozilla 4.77 [en] (WinNT; U) X-Accept-Language: en X-To: biophys@net.bio.net To: biophys@hgmp.mrc.ac.uk X-Razor-id: d6295334de9609602bcf95fa4c1f18dd4e03873c Sender: owner-biophys@hgmp.mrc.ac.uk Precedence: bulk New Paper: The effect of dendritic topology on firing patterns in model neurons. Network: Computation in Neural Systems (2002) 13: 311-325. Van Ooyen, A., Duijnhouwer, J., Remme, M. W. H., Van Pelt, J. Request a reprint: A.van.Ooyen@nih.knaw.nl Or download (free this month) from Network, in PDF format: http://www.iop.org/EJ/S/UNREG/le4r7euPYmgDkGAO,09UUw/article/-ffissn=0954-898X/-ff30=all/0954-898X/13/3/304/ne2304.pdf ---------------------------------------------------------------------------------------------- Abstract: Neuronal firing patterns are influenced by both membrane properties and dendritic morphology. Distinguishing two sources of morphological variability---metrics and topology---we investigate the extent to which model neurons that have the same metrical and membrane properties can still produce different firing patterns as a result of differences in dendritic topology. Within a set of dendritic trees that have the same number of terminal segments and the same total dendritic length, we show that firing frequency strongly correlates with topology as expressed by the mean dendritic path length. The effect of dendritic topology on firing frequency is bigger for trees with equal segment diameters than for trees whose segment diameters obey Rall's 3/2 power law. If active dendritic channels are present, dendritic topology influences not only firing frequency but also type of firing (regular, bursting). -- Arjen van Ooyen, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands. email: A.van.Ooyen@nih.knaw.nl website: http://www.anc.ed.ac.uk/~arjen phone: +31.20.5665483 fax: +31.20.6961006 --- .