-----===[[[ A I D S w i r e D I G E S T 09.06.93 ]]]===----- AIDS Researchers Seeing Their Quarry in a New Light * Baltimore Sun (09/07/93) P. 1A Garrett, Laurie Scientists in the fight against AIDS are excited over a new research strategy that shifts the focus away from HIV itself, and towards how the immune system is effected by this virus. A popular belief is growing that HIV fools the body's immune system into attacking itself and other areas of the body, and that its ability to cause harm is complex and enduring. Dr. Anthony Fauci says, "It's clear that you need the virus at some point to kick off the pathological events. But even if you knocked off the virus early you could still have damage to the immune system." While optimism over these latest findings is somewhat guarded, international researchers gathered at this year's annual AIDS meeting seemed to share in the belief that research should focus on how HIV causes AIDS. On another front, hope for new AIDS treatments, which to date attempt to either block or slow the progression of the virus, or prevent and treat the AIDS-related diseases that inevitably occur, have arisen with these new revelations. Their is talk of completely shutting down and infected immune system and then quickly restarting it in an effort to right the system's course. Also, the possibilities of over-stimulating T-cell responses, or introducing healthy immune system-defending cytokines are being considered. Nominee Expected to Get OK * USA Today (09/07/93) P. 3A Hall, Mimi Surgeon-general nominee Joycelyn Elders is expected to receive confirmation from the U.S. Senate today despite some misgivings concerning her record and rhetoric. Liberals have praised her for being an unapologetic health-care maverick who has not shied away from such weight issues as teen pregnancy and the spread of AIDS. She has repeatedly defended her decision not to disclose reports of defects in condoms being dispensed at Arkansas school health clinics, arguing that it would have undermined public confidence in condoms. Elders has been serving as public health director of Arkansas, appointed by then-Gov. Clinton. Middle-School Condom Giveaway * Washington Times (09/07/93) P. A6 In a program believed to be the first of its kind in the United States, four New Haven, Conn., schools will make condoms available to fifth- and sixth-graders. The program, which begins with the start of classes this week, was granted school board approval partly because of a Yale University survey indicating that 28 percent of the city's sixth-graders are sexually active. Supporters say the program will slow the spread of AIDS and decrease the rate of teen pregnancies. Critics, however, say the availability of free condoms will encourage sexual activity. Luz Gonzales, who runs an AIDS awareness program, disagrees. She points out that New Haven, with 833 AIDS cases, has the highest infection rate of any Connecticut city. Gonzalez says that "Personally, I counsel the kids to stay away from sex, but the reality is that our kids are sexually active." The Center for Population Options says that about 50 school systems across the nation now make condoms available. But New Haven's program is the first time condoms will be given to students below the eight grade. Wives Want Husbands Held Liable for Hiding in Closet * Toronto Globe and Mail (09/03/93) P. A1 Parsons, Charlotte Sophia Bell-Ginsburg made Canadian legal history last June when Justice Alvin Rosenberg of the Ontario Court's General Division gave her the go-ahead to file a $1.4 million suit against Myron Ginsburg, her estranged husband, for not informing her that he was bisexual. Bell-Ginsburg, who argued that her husband unfairly put her at risk of contracting AIDS, is aiming to set a legal precedent that will help other women. She says that the principle at stake is a woman's right to know what kind of risks her husband is taking and decide for herself if she's still willing to be indirectly involved in such practices. Judge Rosenberg contended that Ginsburg had breached his duty as a husband. The Bell-Ginsburg case comes on the heels of an unrelated case of 35 married men arrested for performing "indecent acts" in an Oakville park bathroom in July. Peter Carey, Bell-Ginsburg's attorney, hopes that the successful resolution of his client's case will provide the Oakville wives with an avenue for legal action. Panel Tells Firm to Pay AIDS Victim * Washington Post (09/04/93) P. E1 Mariano, Ann A local real estate company has been ordered to pay $35,000 to a city resident afflicted with AIDS after the company refused to make repairs to his apartment because of his disease. The District's Commission on Human Rights ruled last week that the Joel Truitt Management Co. of the District discriminated against J. Corwin Condren when it would not make repairs to his apartment. The commission found Truitt to be in violation of the District's Human Rights Act, which prohibits discrimination based on a physical handicap. On Dec. 19, 1991, a Truitt employee had demanded that Condren provide assurance from health officials that a plumber scheduled to work in his apartment would not be at risk of contracting AIDS. The employee sent a memo to Condren asking him to "provide certification from a qualified health authority that it is safe to enter your apartment, and that there is no danger of getting the disease and that the apartment is sanitary." Condren, who filed his discrimination complaint on May 18, 1992, lived in the building for three years before moving out in the fall of 1992. The plumbing work was never done while he lived there. The Human Rights Commission ruled that the Truitt company's memo to Condren "implied a restriction of service because of his AIDS condition" and caused him "humiliation, embarrassment and indignity." Truitt was also ordered to pay for Condren's attorneys' fees and the human rights commission's costs of adjudicating the complaint. Attempted HIV-Murder Cases Dropped * Richmond Times--Dispatch (09/03/93) P. B5 Pope, Jon First-degree murder charges against two Virginia prostitutes have been dropped at the request of prosecuting attorney Cassandra S. Burns. Brenda Hines and Rita Conway of Petersburg Commonwealth had been held without bond pending their trials for attempted murder for knowingly having sex after testing positive for the virus that leads to AIDS, HIV. Prosecutor Burns said that she requested dismissals due to the conflicting reports from witnesses involved with the case. "We had problems with these witnesses just like we have problems with rape victims." said Burns. "Its hard to get them to come forward." Originally, a man told police that he had unprotected sex with both women, not having been made aware of their HIV status. Later however, the man vacillated and said that he had used a condom and that both ladies had told him their were HIV carriers. Burns said that the man's statements constituted "perjured testimony," and that she was ethically obliged not to present such differing accounts. In an unrelated case, Johnny Webb, known to be HIV positive, has been charged with eight counts of attempted murder for his sexual exploits with three female minors. Tenor Pavarotti Throws His Weight Into AIDS Fight * Reuter (09/02/93) Italian tenor Luciano Pavarotti last week pledged to help one of the discoverers of the AIDS virus, Dr. Luc Montagnier, and the United Nations Educational, Scientific, and Cultural Organization in their joint effort to fight the disease. Montagnier and UNESCO joined forces last January to form the World Foundation for AIDS Research and Prevention. The foundation said that Pavarotti pledged to donate proceeds from an upcoming concert, and royalties from a record based on that concert, to their organization. Pavarotti said "When a voice given by God can be an instrument to help some great cause like yours, I think a man must be privileged." The foundation, which aims to accelerate research and increase prevention worldwide, says its first project is a three-year, $1 million program in Uganda where it is providing clothing and food to children who have lost their parents to AIDS. The AIDS Commission's Final Plea * Washington Post (09/03/93) P. A24 Four years ago, the AIDS Commission was established to advise Congress and the president on the development of a national policy concerning HIV. Today, it is no more. The final report details the disappointment of members, who feel that the AIDS epidemic has not been taken seriously, and neither have their recommendations. The editors of the Washington Post, however, feel that the commission has provided an important voice in research, education, and prevention. According to the editors, by prodding, goading, criticizing, and demanding action, the commission has had a significant impact. The Post urges that leaders heed the commission's last request for compassion for victims, a commitment of resources, and clear national leadership. Spiritual Duty Seen in AIDS Work * Chicago Tribune (09/02/93) P. 1-7 Griffin, Jean Latz The religious community is putting aside moral judgment and condemnation to help in the struggle against a disease that is primarily transmitted through sexual activity and drug use. Groups are providing health care, shelter, food, friendship, and spiritual guidance to people with AIDS. Experts say that, while this concern and cooperation is praiseworthy, more needs to be done to eliminate the stigma associated with the virus, so that HIV-infected people might receive the spiritual help they need. Ken South, executive director of the AIDS National Interfaith Network, said that the primary problem is the attitude of the religious community about homosexuality. These feelings have been worsened by attempts of right-wing religious sects to use homosexuality and AIDS as political tools. Heterosexual Women Facing Increase in AIDS * Baltimore Sun (09/03/93) P. 1B The number of women acquiring the AIDS virus through heterosexual contact is increasing, according to a state study. Although this figure still remains small, Dr. Joseph Horman of the Maryland AIDS Administration says that the numbers indicate a trend. AIDS- infected females in Maryland have doubled since the early 1980s, rising from about 10 to 20 percent. So far, male homosexuality and intravenous drug use remain the leading causes of infection. David Vlahov, an AIDS researcher at the Johns Hopkins School of Public Health, said that although more women are contracting the disease, the proportion of females with AIDS increases as other segments shrink. September 8, 1993 Key to AIDS: Science Steps a Little Closer * Richmond Times-Dispatch (09/08/93) P. A2 Garrett, Laurie Recent discoveries in past weeks about how the HIV virus catapults the immune system into chaos offers new evidence that perhaps the actual damage is caused not by the virus, but the system itself, report scientists. Previous research has focused on the ability of HIV to harm CD4 cells in the immune system; however, the latest consensus is that the virus tricks the immune system into attacking itself and other parts of the body. This self-destruction, say some scientists, cannot be reversed later even if the virus is eliminated. If this is true, they theorize, a jolt to the system early in HIV infection may set the system back on proper course before opportunistic infections occur. The issue is being both supported and disputed, and in the coming months, many tests will be conducted to test this new theory of immune system chaos. HIV Infects 1M Women This Year * Financial Times (Great Britain) (09/08/93) P. 4 Cookson, Clive More than 1 million women worldwide will be infected by HIV this year, and by the year 2000, 13 million women will be HIV-positive and 4 million will have died from the virus, according to the head of the World Health Organization's global program on AIDS. Dr. Michael Merson reported that females becoming infected with the virus now outnumber males by six to five in sub-Saharan Africa. As more women are infected, their infants are often infected as well. Dr. Merson suggests several avenues of action to protect women, including research to develop a virus-deadly chemical that would prevent HIV infection during sex. AIDS Epidemic Seen to Burden Asian Economies * Reuters (09/08/93) Manila, Philippines--Experts report that, by the year 2000, Asia may surpass Africa in the number of new cases of AIDS, and the epidemic may pose a risk not only to the health of the region, but the economy as well. The issue was discussed at a recent workshop in Manila on the impact of AIDS in Asian countries. United Nations Development Program (UNDP) figures predict that 1 million Asians will be infected annually by 2000. UNDP representative Kevin McGrath urged Asia to practice prevention, and warned that failure to do so could reverse the economic gains achieved by the region. In 1992, there were nearly 2 million cases of HIV-infection in Asia, while Africa reported 7 million. Elders Wins Confirmation in Senate by Vote of 65-34 * Richmond Times-Dispatch (09/08/93) P. A2 Dr. Joycelyn Elders, confirmed yesterday in the Senate by a vote of 65-34, will succeed Dr. Antonia C. Novello as the U.S. Surgeon General. Elders, who is known for her outspokenness, identified AIDS prevention as one of her priorities. She is the first black, and second woman to hold the position. Indian Soldiers Returning From U.N. Duty in Cambodia Test HIV Positive * United Press International (09/05/93) New Delhi--HIV infection has been detected in as many as 45 Indian army soldiers returning from peacekeeping duties in Cambodia, said a report in the Times of India newspaper Sunday. According to the paper, the virus was diagnosed by army medical officers during routine checkups of the soldiers after their return from U.N. operations in Cambodia. Indian army regulations dictate that soldiers may not be discharged after contracting a sexually transmitted disease, but may be disciplined if they refuse to reveal an infection. Authorities are still uncertain about the course of action to be taken against the soldiers. Economic Cost of AIDS Huge and Growing * United Press International (09/08/93) Manila, Philippines--The AIDS epidemic is a serious economic problem, as well as a staggering health dilemma, with developing countries suffering most, according to the Asian Development Bank (ADB). About one in every 250 adults in the world is HIV-infected, and most of these individuals live in non-industrialized countries. With 2,000 people infected each day, Asia is quickly becoming the fastest-growing HIV area, reported a 1992 study by the United Nations Development Program. Vice president of the ADB, Gunther Schulz, said that a shortage of money for expensive treatment programs and medical systems plus a lack of preventative education has hampered the region's battle against AIDS. One Kind of AIDS Virus May Be Main Type Transmitted * Chemical & Engineering News (08/30/93) Vol. 71, No. 35, P. 20 In a finding that is significant in the search for an AIDS vaccine, researchers believe that a particular phenotype of HIV may be the primary one that transmits the virus from person to person. David D. Ho and his colleagues at the Aaron Diamond AIDS Res genotypes of HIV found in recently infected individuals. The sample group included three homosexual men, and two married couples in which the husbands had infected their wives. The researchers found that HIV in these individuals invaded macrophages instead of T-lymphocytes, and did not produce what is called syncytia. Most vaccine theories, however, focus on HIV strains that invade T-cells and do produce syncytia. The implication is that because these strains are not the ones being spread, vaccines that concentrate on them may be ineffective. Prions, Viruses, and Antiviral Drugs * Lancet (Great Britain) (08/28/93) Vol. 342, No. 8870, P. 545 Amor, Sandra and Mehta, Surekha HIV was among the viruses discussed at the 9th International Congress of Virology. At the conference, two groups revealed research on the ability of protease inhibitors to decrease productive infectious virus. Dr. F. Wong-Staal provided information on the most promising aspect for the development of anti-viral treatment for AIDS. Does Zidovudine Delay Development of AIDS? * Lancet (08/28/93) Vol. 342, No. 8870, P. 558 Holmberg, Scott D. and Byers, Robert H. Several cohorts examined HIV-infected men and determined, by tracking incubation time, whether the drug zidovudine delayed the progression to AIDS. Scott D. Holmberg and Robert H. Byers of the HIV/AIDS division of the Centers for Disease Control found a trend for longer incubation periods in all of their analyses. The term from definable HIV infection to AIDS diagnosis was always longer for patients taking zidovudine than for patients who were not taking the drug. The difference in incubation time, however, was not statistically significant. Therefore, the cohorts may not claim that zidovudine deters the development of AIDS, but their analysis is consistent with the Concorde study, which reported the drug as having modest effectiveness in the prevention of AIDS. September 9, 1993 HBO Film on AIDS Premieres * Washington Post (09/09/93) P. D1 Roberts, Roxanne The Kennedy Center last night was the setting for the Washington, D.C., premiere of "And the Band Played On," HBO's docudrama about AIDS. The film portrays the medical mystery about the origins of the disease, and stars Matthew Modine as Don Francis, one of the early researchers at the Centers for Disease Control. The AIDS community hopes that the movie will stir audiences to action with its criticism of the Bush and Reagan administrations' inaction concerning AIDS, and indictments of corporate greed and homophobia. Discussions that occurred after the screening indicated that the pressure was on the president to do something. The invitation-only guest list included more than 800 activists, Capitol Hill staffers, and media representatives, but important names in Congress and the administration failed to attend. "And the Band Played On," based on the 1987 bestseller by journalist Randy Shilts, is scheduled to debut Saturday on HBO. Still Alive: Defying an Epidemic $ Los Angeles Times--Washington Edition (09/08/93) P. A1 Stolberg, Sheryl As the AIDS epidemic continues into its second decade, experts are beginning to focus on a small group of people who are infected with HIV, but are remaining healthy. These "healthy positives" have lived with the virus for 10 or more years without taking antivirals; their immune systems appear to effectively resist HIV. Some researchers are investigating the existence of key proteins which shift the balance of the immune system, and genes which enable cells to fight off HIV or other infection, or a combination of these possibilities. Others feel that healthy positives are simply at the end of a very long bell curve, and will eventually succumb to AIDS. Because the virus can incubate for 10 years or more without exhibiting symptoms, only time will tell. Currently, however, the blood of healthy positives is a hot commodity for those who want to discover the secret of what protects this group, and to develop that knowledge into a vaccine which will create the same effect in others. Economic Cost of AIDS in India Enormous--Official * Reuters (09/09/93) Manila, Philippines--More than 1 million people in India are infected with HIV, and the virus is spreading at an alarming rate, reported Kusum Sahgal, a physician with the National AIDS Control Organization of India. Kusum said that situations in other countries indicate that the cost of taking care of people with AIDS in India will be tremendous. He predicted that India would soon be like some areas in Africa, where 70 percent of hospital beds are occupied by AIDS patients. Given the large population and complex nature of the society, Kusum urged the country to act now--with sex education for young people and more effort on the part of government--or suffer devastating effects. "We have the advantage of lessons learned from other parts of the world.... We have no excuses," he said. Lawsuit Alleges Priest Infected Man With AIDS Virus * Philadelphia Inquirer (09/08/93) P. A3 Denver--In what is the first case of its kind, a Denver man filed suit against a priest who allegedly infected him with HIV. Thomas Perea, 36, claims that Rev. Delbert Blong of the Diocese of Pueblo began sexually abusing him in 1971, and continued to do so until 1992. Perea, who is gay, believes Father Blong infected him because the sex acts with him were unprotected. The priest also allegedly admitted to Perea in February that he was HIV-positive, that two of his male partners were also infected, and that two others had died of AIDS. Perea, who tested positive for HIV in March, said that he had protected sex with other partners, all of whom tested negative. Perea filed the lawsuit in Boulder County District Court against Blong and the diocese, and is seeking jury trial and unspecified monetary damages. AIDS Family * Associated Press (09/07/93) Armour, Nancy Indianapolis--Mark Ellis is the last of three hemophiliac brothers to contract AIDS; the other two have already died, leaving him to wonder when the disease will claim his life, too. The Ellis brothers, like thousands of others suffering from hemophilia, were introduced to the Factor 8 clotting agent in the late 1970s. Factor 8 allowed hemophiliacs to inject themselves with the product, manufactured from donated blood, to stop the bleeding without need of a transfusion. However, this was before blood banks were alerted to the danger of AIDS and developed tests to screen for the disease. According to the National Hemophilia Foundation, half of the country's 20,000 hemophiliacs are HIV-positive, or have developed AIDS. Steppin' Out Announces Week of Events in Downtown Royal Oak to Raise Funds for Those With AIDS and HIV * PR Newswire (09/08/93) Royal Oak, Mich.--Steppin' Out, a nonprofit organization that raises funds for caregivers to people with AIDS and HIV, will host a week of charity events Sept. 12-19 to raise money for its cause. Scheduled events included a shoe auction of footwear * donated by Madonna, Bette Midler, Anita Baker, Willie Nelson, Ted ugent, and many other celebrities; a children's celebration, arts, crafts, music, and entertainment; and a 10k walkathon with an anticipated 4,000 participants. Last year's walk alone raised nearly $100,000. AIDS Front: Who's Minding the Store? * Advocate (09/21/93) No. 638, P. 35 Delaney, Martin The problem with AIDS research is that it lacks direction and control, according to one AIDS expert. No one is in charge, says Martin Delaney, the founding director of Project Inform, which distributes AIDS treatment information around the world. The result, attests Delaney, is that key research questions remain unanswered for years because they are not being studied in a systematic manner. Everyone is choosing their own work, setting their own goals, and failing to coordinate anything. Delaney contends that researchers and scientists must focus less on the old maxims of science and more on goal-oriented, team-directed, problem-solving approaches in order to make some progress. He insists, however, that change cannot be accomplished without public demand for it, and urges people to write to White House AIDS policy coordinator Kristine Gebbie. Martin Delaney is the co-author of "Strategies for Survival: The Gay Men's Health Manual for the Age of AIDS." HemaCare Plans National Clinical Trials of Immupath * Business Wire (09/07/93) Los Angeles--At a recent pre-investigational new drug (IND) meeting with the U.S. Food and Drug Administration, representatives of HemaCare Corp. announced plans to conduct national trials of a bio-pharmaceutical product, Immupath, as a potential treatment for AIDS. Discussion at the meeting included clinical trial design, plasma processing facility design, and validation and licensure of plasma donation centers. HemaCare completed a Phase II study of Immupath in July. The results were encouraging, and the company is awaiting approval for a Phase III study. HemaCare is currently preparing a formal IND application for submission to the FDA as a result of that meeting. Sheffield Forms Agreement With CBR Laboratories, Scales Up Production of AIDS Compound for Phase II Clinical Trials * Business Wire (09/07/93) Houston--Sheffield Medical Technologies Inc. announced an agreement with CBR Laboratories to produce the company's red blood cell (RBC)-CD4 Complex for use in Phase II clinical trials in patients infected with HIV. The contract provides for CBRL to scale up and deliver the electroinsertion equipment to Sheffield. CBRL will also do the actual electroinsertion of CD4 into the red blood cells, thus forming RBC-CD4. RBC-CD4 acts like a sponge to HIV-infected cells floating in the bloodstream. Once internalized in the CD4, HIV disintegrates and is no longer infective. Sheffield President Douglas R. Eger said that the trials, scheduled for the end of 1993, will demonstrate the importance of RBC-CD4 in the battle against AIDS. September 10, 1993 Gene Therapy--AIDS * Associated Press (09/10/93) Recer, Paul Bethesda, Md.--The Recombinant DNA Advisory Committee, a panel which evaluates human gene therapy techniques, will vote Friday on a proposal to insert a genetic trap into the CD4 cells of AIDS patients. The experiment, designed by Drs. Flossie Wong-Staal, Eric Poeschla, and David Looney of the University of California in San Diego, proposes the removal of CD4 lymphocyte cells from HIV-infected patients. The cells, which are primary targets of the AIDS virus, would then be altered by the insertion of a ribozyme that can slice up RNA. Because HIV uses RNA to reproduce itself in CD4 cells, the injected ribozyme prevents HIV from replicating or from infecting new cells. If enough cells carried the altered gene, the amount of HIV in the patients would be reduced; therefore, about 10 billion new cells would be cultured before the cells are infused back into the patients. Wong-Staal said that her group wants to experiment with six human patients, and if successful, expand the therapy to more patients. Cesareans May Reduce Spread of AIDS to Babies * Reuters (09/09/93) London--Performing cesareans during childbirth may lower the chances of women transmitting HIV to their unborn infants, according to a report by pediatricians at the Italian university of Turin. One study indicated that babies delivered by C-section had a 14-percent risk of being born with the AIDS virus, while those born via vaginal delivery had a 20-percent risk, the report said. Although scientists have not yet determined exactly how and when HIV is passed from mother to fetus, one pediatrician wrote that Cesarean babies were less exposed to infected blood and vaginal fluid. The mixing of blood between mother and child peaks during labor, the report explained. The pediatricians called for more research concerning the benefits of early surgical delivery for HIV-infected women, although this could raise ethical issues since the operation may be dangerous for some women and their babies. Red Cross Agrees to Aid Blood Victims * Toronto Globe and Mail (Canada) (09/09/93) P. A5 Mickleburgh, Rod The Canadian Red Cross, which faces more than 120 lawsuits for spreading the AIDS virus through contaminated blood, will finally offer financial assistance to people who were infected with HIV. In the early years of the disease, before safeguards were established for the blood supply, the Canadian Red Cross passed along tainted blood to more than 1,000 hemophiliacs and transfusion patients. Doug Lindores, secretary-general of the Canadian Red Cross Society, said that the organization denies any liability, but that the money being spent on legal costs could be redirected to HIV-infected individuals. Recipients, however, must sign a waiver obliging them to drop any legal action against the Red Cross. Lindores said that the contribution would be small, but would be part of a larger, more extensive aid package being assembled by most Canadian provinces. Diana Calls for Understanding Towards AIDS Mothers * Reuters (09/08/93) Forrester, James Edinburgh--In her address to 500 delegates meeting at Heriot Watt University in Scotland, Princess Diana of Great Britain pleaded for compassion towards HIV-infected mothers. She said that these women suffer from the "grief and guilt" of knowing that they probably will not see their children through to independence. Princess Diana first became alerted to the plight of such women while in Zimbabwe, where she witnessed first-hand how the tragedy affects the entire family. During her speech, the princess also cautioned against believing that "AIDS is someone else's problem." Germany Pledges Money to HIV-Infected Haemophiliacs * Reuters (09/09/93) Bonn--After pledging $1.25 million to hemophiliacs who were infected with HIV through blood transfusions, German Health Minister Horst Seehofer urged other organizations to do the same. About 400 hemophiliacs who received tainted blood between 1982 and 1985 have already died from AIDS. Of the country's 6,000 hemophiliacs, at least 1,500 are HIV-infected. Seehofer said that the government's donation is not an admission of responsibility. He called on the Red Cross, the pharmaceutical industry, insurers, and the federal states to contribute to the fund in order to reach an amount of $6.25 million. The fund would then allow monthly payments of $1,250 to hemophiliacs who were infected. Jamaica * Associated Press (09/08/93) Kingston, Jamaica--Hospital employees have been cleared of negligence after their hospital accidentally gave patients blood tainted with HIV. The University Hospital of the West Indies said that two patients, one of whom has since died of terminal lung cancer, were given the contaminated blood on March 30. The mistake of an employee in reading the serial number led to the contaminated unit being retained, rather than discarded. Dr. Grace Haynes, director of the ministry's Blood Transfusion Service, said that the HIV-infected blood was permitted to leave the blood bank due to clerical error as well. The hospital has accepted full responsibility for the other patient, though no further details on the patient's condition were given. Seven Bulgarian U.N. Peacekeepers Catch AIDS * Reuters (09/09/93) Sofia--Several Bulgarian soldiers contracted the AIDS virus while performing U.N. peacekeeping duties in Cambodia, reported the state news agency BTA. Quoting a colonel of the Bulgarian army, BTA said that, of the 1,244 Bulgarians who had returned from Cambodia, seven were infected with HIV. Of a population of 8.5 million, there are slightly less than 200 cases of HIV in Bulgaria. Wellcome Defends Patent for AIDS Medication AZT * Pharmaceutical Representative (09/93) Vol. 23, No. 9, P. 2 After a two-year legal battle, a U.S. District Court in New Bern, N.C., upheld the claim of Burroughs Wellcome as the sole inventors of AZT, a treatment for HIV. The case began in 1991 when Barr Laboratories and Novopharm Inc., in separate incidences, submitted applications to the FDA to manufacture the drug. Burroughs Wellcome filed suit for patent infringement, and the lawsuit ensued. The defendants contended that Wellcome's patents for AZT were invalid because they failed to credit two NIH scientists as co-inventors after they tested the drug on human cells infected with HIV. The court, however, upheld Wellcome's claim that its own scientists decided to use the drug to treat AIDS weeks before they asked the agency to test it. Wellcome began marketing AZT in 1987, and has been criticized for the high price of the drug. Priorities for HIV Testing in Developing Countries? * Lancet (09/04/93) Vol. 342, No. 8871, P. 601 Colebunders, Robert and Ndumbe, Peter HIV testing in developing countries is not always feasible because of lack of equipment, high cost, or both. Cheaper tests are more feasible, but less reliable. According to Robert Colebunders of the Institute of Tropical Medicine in Belgium, and Peter Ndumbe of the Virus Immunology Unit at the University of Yaounde in Cameroon, HIV testing should be made more widely available in developing countries, but only for specific purposes. They suggest that each country establish guidelines and priorities for HIV testing. Aside from maintaining a safe blood supply, there is no evidence that HIV testing reduces the spread of the virus. The focus, therefore, should not be on actual testing, but on counseling people with high-risk behavior, say Colebunders and Ndumbe. Until health care in developing countries improves, HIV testing merely for diagnostic purposes is inappropriate, they conclude. NOTE: Compilation by Michael Tidmus : AIDSwire. All rights reserved. Permission is granted to republish on electronic media for which no fee is charged, provided the complete text of this notice is attached to any republished portion or portions. * From the AIDS Daily Summary. The Centers for Disease Control and Prevention (CDC) National AIDS Clearinghouse has made this information available as a public service only. Providing this information does not constitute endorsement by the CDC, the CDC Clearinghouse, or any other organization. Reproduction of this text is encouraged; however, copies may not be sold. Copyright 1993, Information, Inc., Bethesda, MD. -----===[[[ A I D S w i r e D I G E S T 09.06.93 ]]]===----- .