-----===[[[ A I D S w i r e D I G E S T 07.26.93 ]]]===----- AIDS Complicates the City's Pledge to House Homeless * Los Angeles Times--Washington Edition (07/26/93), P. A7 Bearak, Barry New York City spends $7.2 billion a year on social services, and about $500 million of that money goes toward housing the homeless. In 1981, New York became the first U.S city to provide shelter on demand for the homeless. The AIDS epidemic, however, has complicated the housing issue. People with weakened immune systems cannot stay at group shelters. In the 1980s, the high number of infected drug addicts worsened the housing problem. Because community groups refused to permit any new AIDS housing, the city turned to single-room occupancy hotels, or SROs. The hotels, however, have been at full capacity for a year now, and the city transfers the overflow of new AIDS clients to emergency assistance unit offices. Within five years, New York's Division of AIDS Services has expanded from five to 500 caseworkers, but it is still chronically understaffed. "People get placed in the SROs and then get forgotten about," said division head Stephen Fisher. Other cities, such as Baltimore, Chicago, and Washington, D.C., also have vast numbers of drug addicts who are infected with the AIDS virus. Soon, these cities may face the same housing dilemma as New York. Fortunately, AIDS activist groups and not- for-profit organizations have opened some of their own housing, and New York may pioneer some novel AIDS housing solutions. Waiting to Die at the AIDS Hotel * Los Angeles Times--Washington Edition (07/26/93), P. A1 Bearak, Barry In New York City, homeless people with AIDS are entitled to private rooms in one of the city's 34 single-room occupancy hotels (SROs). To receive a room, however, an individual must have an M11Q form signed by a doctor, proving that they have full-blown AIDS. Although the city's homeless shelters are not suitable for individuals with AIDS, it seems that SROs are no better. Because most homeless people with AIDS are drug addicts, SROs have become little more than government- subsidized crack dens. "Put someone in an SRO and even if their substance abuse is minimal, hands reach out in those dim hallways day and night to sell them drugs," said Anita Vitale, director of case management for the city's AIDS division. Today, about 10 to 15 percent of Americans with AIDS are also homeless, and that figure is rising. Housing solutions, however, are only now starting to catch up. A small federal program for AIDS housing began last year, and organizers are only now planning the first national conference on housing strategies. Surgeon General Nominee Elders Ends Senate Hearing in Stronger Position * Wall Street Journal (07/26/93), P. A7A Stout, Hilary After her confirmation hearing, President Clinton's nominee for surgeon general, Joycelyn Elders, was in a better position to withstand attacks from conservatives. Elders, who previously headed the Arkansas Department of Health, has been criticized by conservatives and right-wing religious groups for her support of condom distribution in schools, abortion rights, and the inclusion of human sexuality lessons in elementary-school curricula. Although Elders was also questioned about personal finance matters, her explanations seemed to satisfy most members of the Senate Labor and Human Resources Committee. A vote is scheduled for Friday, and the committee is likely to approve Elders' nomination. The full Senate could take action on the matter before its summer recess. During the hearing, Elders said she believes youths should be taught abstinence. However, she added that because some youths also engage in sexual intercourse, they must be taught responsible sexual behavior, such as how to use condoms to protect against AIDS and pregnancy. Elders also discussed an Arkansas school health clinic system she had started, and noted that the school districts themselves decided which services to provide, and parents could also determine which services their children received. AIDS Patients Contest Utah Ban on Marriage * New York Times (07/25/93), P. 28 Two Utah women with AIDS are suing to overturn a state law that bars people with the disease from marrying. Upon learning of the suit, Governor Mike Leavitt blocked enforcement of the law until the legislature can reconsider it in January. Even Stephen J. Rees, the state senator who sponsored the bill in 1987, now says, "I don't know what we were thinking." The women, however, will continue with the case, in which they also seek financial compensation. Plaintiff Cindy Kidd says, "Prosecutors are not enforcing the law now. But what about third parties? My insurance company may say, 'Oops! We won't pay your health bill because you weren't legally married.' Then what?" Dangerous Liaisons * Los Angeles Times Magazine (07/25/93), P. 10 Jones, Robert A. "While HIV transmission among older men who have sex with men is sharply reduced from the early '80s, transmission continues at high levels in younger gay men," says a report by the National Commission on AIDS. This finding simply confirmed what researchers had suspected as early as two years ago: that the younger the gay man, the more likely he is to engage in high- risk sexual behavior. A 1991 study by the San Francisco Department of Public Health found that among the men surveyed, 30 percent of those between 23 and 25 reported recently having unprotected intercourse, compared to 43 percent of those between 17 and 19. Eighty-two percent of the older group reported having unprotected oral sex, compared to 90 percent of the younger group. The study also found that 10.4 percent of the 23- to 25-year-olds were HIV-positive, compared to 14.3 percent of the 17- to 19-year-olds. AIDS researchers have tried to explain the findings by saying that younger people tend to feel immortal and so take risks with their lives, or that young gay men have not yet developed the social confidence to discuss safe sex with their partners. These explanations imply that when the older groups were between 17 and 19 they engaged in the same risky behavior. However, the San Francisco study found that today's youngest gay men are taking more risks than the generation before them did at the same age. Too Many Questions on Tainted Blood * Toronto Globe and Mail (Canada) (07/26/93), P. A18 How 1,000 Canadians became infected with HIV before 1985 through tainted blood and blood products remains unclear, write the editors of the Toronto Globe and Mail. There are many indications that some of the cases could have been prevented. Until the early 1980s, AIDS was poorly understood, and consequently, largely unpreventible. By 1982, the link between blood and the disease was made, and by Sept. 29, 1984, the Lancet published a study proving the virus could be killed through heat-treatment of blood. The Canadian Red Cross, however, did not begin buying heat-treated blood products until Dec. 12, 1984. Ottawa had apparently known that its blood supply was contaminated, but did not know what action to take. According to Greg Smith, the current director of Health and Welfare Canada's assistance program, they knew much sooner than July, 1984, about the contaminated blood supply, but "there was nothing to replace [the blood] with. There wasn't enough of the heat-treated product. You had to make some difficult medical choices." It is unclear why there were shortages of heat- treated blood products until late 1985 and why hemophiliacs were not warned about potentially unsafe blood products and informed about alternatives. Canada's implementation of a screening program was also delayed until November 1985. Ottawa's public inquiry into the nation's blood supply will focus on the future safety of blood. Determining what happened to the blood supply in the 1980s is vital to the national interest, conclude the editors. MGH Offers Apology for Error in AIDS Data * Boston Globe (07/23/93), P. 6 Foreman, Judy Officials from the Massachusetts General Hospital (MGH) apologized last Thursday for an "unfortunate error" by researchers who claimed to have discovered what could be "the Achilles' heel" of HIV last February. Researchers said the reported treatment had stopped replication of HIV in a test tube. However, researchers later found that the MGH research was seriously flawed. Nonetheless, said National Institute of Allergy and Infectious Diseases director Anthony Fauci, the findings do not mean that the researchers' results are useless or that the federal government will stop its trial involving 400 people. The MGH research involved an idea called combination therapy, which involves blasting AIDS with three drugs. It is not likely that the virus would be able to adapt to so many drugs at once and thus would not be able to reproduce. The researchers used AZT and ddI along with pyridinone or nevirapine. The researchers reported that the combination of drugs prevented the virus from growing and spreading in the test tube. However, the MGH researchers reported recently that the virus does become resistant to all three drugs eventually. The researchers erred in their third experiment, in which they added four genes to the AIDS virus known to cause drug resistance, and determined that because the virus could not survive, their theory was supported. However, the researchers did not know initially that their mutant viruses contained a fifth mutation capable of killing the virus on its own. Peptide T Unavailable in Buyers' Clubs * AIDS Treatment News (07/09/93) No. 178, P. 7 James, John S. Because buyers' clubs throughout the United States have been unable to obtain supplies of peptide T, approximately 3,000 AIDS patients have been denied access. Peptide T, which has been in drug development for several years, is not federally approved and therefore can only be sold in buyers' clubs or through other underground sources. The drug is used to treat AIDS-related neurological problems, especially painful neuropathy and cognitive disorders, and it is believed to be entirely safe. The immediate reason for the cutoff is that the European supplier decided not to sell it any more to the U.S. buyers' clubs. In January 1992, peptide T was cut off as a result of a new round of clinical trials, which brought peptide T under a different legal framework and under a different bureaucracy within the Food and Drug Administration. It is unknown exactly why the recent cutoff occurred. It may have resulted from fear of the FDA, but without any specific action by the federal agency. However, it appears that peptide T will not be available in the near future. July 27, 1993 Faith in Multiple-Drug AIDS Trial Shaken by Report of Error in Lab * New York Times (07/27/93), P. C3 Altman, Lawrence K. Massachusetts General Hospital and Harvard Medical School scientists admitted last week that they found a grave error in a theory supporting a new type of drug therapy for HIV. The error highlights the great pressures on AIDS scientists to work rapidly while upholding scientific standards, as well as the pressures on federal health officials to rush into clinical trials for AIDS drugs. The Harvard trial was launched without independent confirmation of preliminary research findings. The research, carried out by a Harvard medical student, was also found to be sloppy. The student published without repeating important steps to verify vital data. In addition, the student's team misread laboratory data and failed to detect a fifth mutation in the virus used in the experiment. According to experts, the flawed research has clouded hopes that the trial could lead to an important advance in therapy. However, volunteers are being asked to continue using a combination of three drugs--the experiment's strategy. Some experts feel that the desperate AIDS situation is grounds for testing drugs in a variety of combinations. Other studies, they say, support such therapy. Members of the AIDS community and researchers are now at odds over the research, with AIDS activists claiming that researchers intentionally manipulated the system to boost the size of the trial, which the research's supervisor, Dr. Martin S. Hirsch, denies. Volunteers have been sent letters explaining the facts of the drug trial. AIDS in California * Business Wire (Sacramento, CA) There were 8,513 AIDS cases reported in California last year, in an increase of 4.3 percent from 1991. About 72 percent of cases were reported by homosexual or bisexual men, an increase of 0.8 percent over the previous year. More than 10 percent of cases were due to injection drug use, up 20 percent from last year, and compared to a slight decrease nationally. Almost 500 women in California reported having AIDS in 1992, up 17.6 percent from the previous year, and compared to an increase of 9.8 percent nationally. While new national statistics show that more women are developing AIDS from heterosexual contact than injection drug use, California statistics have shown the opposite since 1895. In 1992, 42 percent of California women with AIDS contracted the disease through injection drug use, 35.3 percent from heterosexual contact, 9.3 percent from contaminated blood products, and 12.8 percent from unidentified sources. City Health Chief Vows Help for AIDS Groups * Philadelphia Inquirer (07/27/93), P. B5 Collins, Huntley Philadelphia's city health commissioner has vowed to find city and state funds for local AIDS organizations that were passed over for federal funding. Robert K. Ross, speaking at a meeting of The Philadelphia AIDS Consortium (TPAC), said that because many local agencies had not been properly forewarned about new competitive bidding techniques for federal funds, he would find a way to give temporary financial support to several local organizations. However, Ross warned that competitive bidding is "the way government is going," and that this year's aid should not be expected in the future. Before Ross' placating words, some blacks had been angry over the dispersal of the Center for Disease Control and Prevention's funds. Ross pointed out that three of the five AIDS organizations that received funding were "of color," and he stressed the importance of resolving the city's problems concerning AIDS funds. He said that unless problems within the fund distribution process were eradicated, Philadelphia could lose millions of dollars in future federal funding. Prostitution, Prejudice Fuel AIDS Epidemic in Honduras * Los Angeles Times--Washington Edition (07/27/93), P. C1 Wilkinson, Tracy Honduras now has Latin America's highest rate of AIDS cases. In the country, where the disease is spread through an active prostitution industry, AIDS patients are outcasts. Health care workers, the poverty-stricken society, and worried government officials are staggered by the epidemic. Honduras, with about 15 percent of Central America's population, has 60 percent of the region's AIDS patients. While 2,700 cases of full-blown AIDS have been reported in the country, the Health Ministry estimates 50,000 Hondurans may be infected. But there is a distinct shortage of care available for the patients. "There is a lot of fear. People don't want to be around AIDS victims, much less care for them. Most of them have nowhere to go," said nurse Helen O'Connor. Most patients end up at shelters such as the San Jose Hospice. Of the Hondurans infected with HIV or suffering from AIDS, about two-thirds are heterosexual, and slightly over half are women. Health officials in San Pedro Sula are now discovering that almost 4 percent of pregnant women with no risk factors are infected with HIV. The spread of the disease is exacerbated by rampant prostitution and by the reluctance of Honduran men to use condoms. The government is now promoting condom use in extramarital sexual contacts. State Seeks Comment on Use of AIDS Funds * United Press International (07/26/93) (Indianapolis) A public hearing will be held on August 4 at the Indiana State Department of Health, for the purpose of getting the public's views on the continued use of funds obtained through the Ryan White Care Act. The Indiana State Department of Health has received $753,940 from the program in 1993, with much of the funding going towards a care consortium. The consortium's main objectives, thus far, have been to coordinate medical care, intervention programs, dental services, and psychological care through various state agencies. Moreover, the consortium has given financial support for medicine and/or living expenses to those who have tested positive for HIV or who have already acquired AIDS. Individuals interested in commenting on the use of the funds should attend the meeting or write to James Lollis Jr., assistant director of the Indiana State Department of Health's Division of Acquired Diseases. Illinois Company Set to Test Blood Substitute in U.S. * Knight-Ridder (07/23/93) Leung, Shirley (Chicago) Baxter International has announced that it will expand clinical tests of its hemoglobin-based blood substitute to hemorrhagic-shock victims at St. Francis Hospital in Tulsa, Oklahoma. With a patented chemical cross-linking process, Baxter has stabilized a human hemoglobin molecule from outdated blood so that it can carry oxygen to tissues. Scientists currently maintain blood volume with plasma and other artificial materials, but the hemoglobin solution, DCLHb, can also carry oxygen, which is important to trauma victims and heart-surgery patients. The chemical process also kills all viruses that could have come from the hemoglobin, including HIV and hepatitis. However, "The hemoglobin is not a red blood cell, and we don't know how the body will react on a long-term basis," said Irving Miller, head of the chemical engineering department at the University of Illinois in Chicago. Taking a Very Large Dose of Can-Do * Financial Post 500 (Canada) (1993) No. 3070, P. 68 Levin, Martin Francesco Bellini, chief executive officer of BioChem Pharma Inc., hopes to propel the firm into the ranks of the world's leading pharmaceutical companies. The Canadian company may become a leader in AIDS research with its drug 3TC, according to Bellini. BioChem has formed ventures with U.K., German, and Swedish firms that pay 12 percent in royalties, a figure that remains well above industry standards. Glaxo Canada Inc. signed with BioChem to market 3TC in North America and holds production rights for the rest of the world. In January, Glaxo invested C$30.3 million in BioChem, raising its stake to C$72 million and its equity to 17 percent. BioChem's philosophy stresses flexibility, with scientists and business managers treated as equals. Everyone in the company receives stock options. 3TC currently appears to be as effective or more effective than AZT. Phase 1/2 clinical testing in North America and Europe has indicated that patients gained weight, had an increase in appetite, and had more energy. Also, the patients did not have major side effects. BioChem anticipates the drug will begin Phase 2/3 trials. Timothy Wilson, an analyst with Hambrecht & Quist Inc., suggested investors buy BioChem stock in January based on 3TC. Wellcome's AZT Faces Attacks on Two Fronts * Business Week (07/26/93) No. 3329, P. 36 Flynn, Julia et al. Although Burroughs Wellcome has seen monetary success from its anti-AIDS drug AZT since 1987, the company is now under attack for its patent and clinical reputation. In a lawsuit currently being tried in North Carolina, Burroughs Wellcome is seeking to prevent generic drug makers Barr Laboratories Inc. and Novopharm from producing cheaper versions of AZT. Barr and Novopharm, supported by the National Institutes of Health, claim Burroughs Wellcome's patents for AZT are invalid because NIH researchers co-invented the drug. But even if Wellcome maintains its patents, the role of AZT as the primary treatment for HIV-positive patients is declining, according to Dr. Anthony Fauci, director of the National Institute of Allergy & Infectious Diseases. If Wellcome loses the suit, the lost profits would be substantial. Novopharm and a Barr subsidiary already sell generic versions of AZT in Canada, at about half Burroughs Wellcome's treatment price of $2,100 per year and claim that U.S. discounts would be similar. Not only are Wellcome's patents threatened, but also its clinical reputation. The European Concorde trial revealed that AZT is not effective when taken early in the course of HIV disease. Consequently, in late June, an NIH panel concluded that while AZT should remain a first-line drug for HIV-positive people, doctors may consider not using it for patients not yet exhibiting symptoms. Only about 1 percent of infected people in the United States currently receive AZT. And before the Concorde trial revelations, asymptomatic patients were expected to account for 20 percent of U.S. sales. However, now Wellcome's market share is expected to stay at eight percent, said analyst Jo Walton of Lehman Brothers. Grim Reality: AIDS Is Cutting a Wide Swath Through the Nation's Young Adults, A Federal Study Shows * Advocate (07/24/93) No. 634, P. 24 Bull, Chris Because of a recently released federal report showing that AIDS has surpassed accidents, cancer, and heart disease as the leading cause of death among young adults in five states and 64 cities, epidemiologists and policy makers have renewed their demands for enhanced prevention efforts targeting the disease. Susan Y. Chu, a Centers for Disease Control epidemiologist who co-authored the report, said, "The study says that people are dying all over the place, more so than we ever imagined. We're hoping this will shock people out of their complacency." The study revealed that AIDS is the second leading cause of death among men ages 25 to 44, behind only unintentional injury. Among women in the same age group, AIDS is the sixth leading cause of death, ranking behind cancer, unintentional injury, heart disease, suicide, and homicide. Chu said that the actual number of people who died of AIDS-related complications that year was probably even higher than the number indicated in the report, since the study's authors predict that nationally, AIDS-related deaths are underestimated by about 35 percent because of poor reporting standards in state health departments. Karen Wines, director of development for the Hyacinth AIDS Foundation in New Brunswick, N.J., said that in her state AIDS prevention efforts rarely target the predominant AIDS population of IV-drug users because they tend to be members of racial and ethnic minorities. She said, "The question is 'Are we getting enough funding for prevention and for treatment of people who are sick?'" She added, "The answer is 'Absolutely not,' and the result is that more and more people are going to die and the epidemic is going to get even worse." HHS Fumbles Ball on AIDS Vaccine Trial * Science (07/09/93) Vol. 261, No. 5118, P. 151 The Department of Defense and the Department of Health and Human Services have been at odds for the past several months over which agency will conduct a $20 million AIDS vaccine trial. Since last fall, the two agencies have been trying to decide how to proceed with a congressionally mandated clinical trial of a therapeutic AIDS vaccine made by MicroGeneSys Inc. of Connecticut. The DOD decided in April to give the money to the HHS following prolonged negotiations. The talks over the vaccine trial started last October, when Congress bypassed the peer-review process and appropriated $20 million to be given to DOD to test MicroGeneSys' AIDS vaccine. But this spring a panel of the National Institutes of Health decided that the money would best be spent comparing several vaccines. Therefore, the DOD agreed on April 7 to hand over the money to HHS for the trial. But HHS now wants to return the funds to the DOD because the agency's policy prohibits HHS from paying for experimental products. HHS general counsel Harriet Rabb wrote to a DOD lawyer on June 21 saying "a high-level member of HHS' staff" had tried--but failed--to "persuade" MicroGeneSys to donate vaccine. Nevertheless, now that DOD has the vaccine, it also says it will not proceed with a trial unless MicroGeneSys donates the vaccine. If the biotech company refuses, the $20 million would go to DOD's AIDS general research budget. July 28, 1993 Confirm Dr. Elders * Minneapolis Star Tribune (07/28/93) (Minneapolis, MN) The editors of the Minneapolis Star Tribune contend that Dr. Joycelyn Elders, President Clinton's choice for top health official, is hardly a "white-bread" candidate. As director of the Arkansas Health Department, Elders supported both condom distribution and sex education in public schools, arguing, "We've taught them what to do in the front seat of the car, but not what to do in the back seat." Elders detractors have attacked her on these points, insisting that public-health efforts should be geared toward promoting sexual abstinence. But the editors of the Minneapolis Star Tribune argue that the opponents' anger is as irrational as it is extreme. The editors agree with Elders' point that no sensible public-health professional can depend on sermonizing as a cure-all for the pressures today's teenagers face. In fact, they point out that Elders' views differ little from former surgeon general and Reagan-appointee C. Everett Koop, who advocated condom use as a shield again AIDS and teen pregnancy. The editors contend that Elders should not be punished for wanting to take matters a few steps further. China-AIDS * Associated Press (07/27/93) (Hong Kong) China's Cabinet has announced that it will restrict the work, home, and school lives of residents within its Guangdong province who are infected with AIDS. The number of reported HIV cases within the province has risen from zero three years ago to 63 at present. Although no indications have been given to suggest similar measures elsewhere, HIV carriers in Guangdong will now be subject to the government's will in marriage, employment, and movements abroad. The Ta Kung Pao newspaper has reported that, in an effort to counteract the province's booming drug use and prostitution, Chinese officials are promoting condom use and disposable needles. It's Time for Ontario to Pay Blood Money * Toronto Globe and Mail (Canada) (07/27/93), P. A17 Crozier, Karen L. According to Toronto-based lawyer Karen Crozier, those in Ontario who have been infected with the HIV virus through tainted blood should receive financial retribution most expeditiously. Crozier says there is no need for a set payment program to be in place before victims get much needed funds, and that Health Minister Ruth Grier should immediately begin assistance. Crozier alludes to insurance programs that often begin payment as soon as liability is established as evidence that payment details can be worked out later. Crozier warns that a failure to begin retribution for those infected would place Ontario in a position of hypocrisy, and reveal the health-care system to be void of human compassion. Crozier goes on the urge for more controls within the health-care industry, and says that everyone should share in the guilt, because complacency within Ontario's population, in regards to medical standards, was a contributing factor to this tragedy. Finally, Crozier urges concrete action now, so that in the future, companies will expect monitoring and, when needed, intervention. AIDS & Country Caring * Washington Post (07/28/93), P. C7 Harrington, Richard The country music industry is gearing up to join the battle against AIDS. Country singer Mary-Chapin Carpenter has been named chairman, along with fellow singer Mark Chestnutt, of the "Country Music AIDS Awareness Campaign Nashville," which will feature a series of public service announcements from a variety of stars. Among the more well-known participants are Garth Brooks, Wynonna Judd, and Willie Nelson. The campaign will break nationally in January and reach an estimated 50 million people. In addition, Nashville's Opry House will host a benefit concert for Nashville CARES, the local AIDS support organization, near the end of the year. Also, next March will see the new compilation album "Red Hot + Country" hit stores, with proceeds going to AIDS organizations. Recent reports have shown that AIDS is growing fastest in the South and in rural areas in general. Eyeing Buyers Clubs * American Druggist (07/93) Vol. 208, No. 2, P. 11 Ostrowidszki, Victor The Food and Drug Administration is taking a tougher stance on the underground businesses known as AIDS "buyers clubs." The FDA cautioned the clubs that extreme promotion of their merchandise could constitute health fraud. In addition, the agency ordered the clubs conduct their operations under the supervision of a physician and warned them against distributing potentially harmful products. In a letter to the 12 recognized buyers clubs, the policy was outlined by Dr. Randolph F. Wykoff, director of the FDA's office of AIDS coordination. The "FDA has become increasingly concerned about certain potential threats to the health of people with AIDS and advanced HIV disease posed by the activities of some groups," said Wykoff. "These include: The lack of physician involvement in the medical care of their clients; the sale of injectable products of unknown purity, sterility, and strength; the sale of products with unknown sources of manufacture; and the promotion, distribution, and commercialization of unproven and potentially dangerous products." The FDA has permitted HIV- positive patients to import unapproved treatments under a "personal use" policy. As a result of this demand, buyers clubs have emerged to serve as information clearinghouses for treatment alternatives. Buyers for the underground operations obtain the drugs abroad that either are not available in the United States or are available only at much higher prices and subsequently distribute them to patients. AIDSFront: Medical Briefs * Advocate (07/27/93) No. 634, P. 39 Delaney, Martin The South West Community Based AIDS Treatment (ComBAT) Group has launched a clinical trial of the anti-AIDS drug 3TC for HIV-positive volunteers. The drug is a reverse transcriptase inhibitor that interferes with the enzyme that HIV uses to copy its genetic material. According to laboratory reports, 3TC is active against strains of HIV that are resistant to AZT. ComBAT and 19 other locations nationwide are sponsoring the 3TC trials, which will last for about a year. The organization is seeking 100 HIV-infected men and women as volunteers. Viral Quasispecies * Scientific American (07/93) Vol. 269, No. 1, P. 42 Eigen, Manfred Using a combination of mathematics, chemistry, and biology, Manfred Eigen has classified the nature of viruses, including HIV, as a "quasispecies." He defines quasispecies as a group where all members help to continue the stable population. Fitness of the whole matters more than fitness of the individual. Eigen notes that viruses are listed in three different ways--a single strand of ribonucleic acid (RNA), encoders of their messages as minus strands of RNA, and retroviruses. The primary function of viruses is self- preservation through mutagenesis, reproduction, proliferation, and adaptation to a steadily changing environments. HIV, for example, has 10,000 nucleotides, but each nucleotide has one of four possible bases--adenine, uracil, guanine, or cytosine. Because the quasispecies functions as a whole, it relies on its error rate, or the probability that an error will occur when one nucleotide is duplicated, to set its size and integrity. Eigen's group determined the incidence of constant, variable, and hypervariable sites in HIV and several other viruses. About 20 percent of the positions are constant and 70 percent of the positions are variable with a lifespan of about 1,000 years, suggesting the virus has survived for 600 to 1,200 years. Insurance Status Among People With AIDS: Relationships With Sociodemographic Characteristics and Service Use * Inquiry (Summer 1993) Vol. 30, No. 2, P. 180 Fleishman, John A. and Mor, Vincent AIDS patients without insurance were admitted to hospitals as inpatients less frequently than those with private insurance, and they had fewer inpatient nights, write John A. Fleishman and Vincent Mor of Brown University in Providence, R.I. The researchers interviewed 937 AIDS patients who were recruited from outpatient HIV clinics and community-based AIDS service organizations in nine communities nationwide. They found that 30 percent of the patients had private insurance, 29 percent had no insurance, and 41 percent were covered by some form of public health insurance. The study revealed that respondents who were nonwhite, IV-drug users, unemployed, and had incomes of less than $500 per month were more likely than their respective counterparts to have no insurance or to have publicly funded insurance. There were significant regional variations in insurance status, with the South having the highest rate of uninsured and the lowest proportion receiving Medicaid. Approximately 95 percent of the uninsured and the publicly insured, compared to 47 percent of those with private insurance, used clinics as their source of medical care. As the AIDS epidemic spreads to more second-wave or third-wave communities, the number of affected people will increase in states with restrictive Medicaid policies. The pattern discovered in the South of a lack of both private and public insurance may become more common. The researchers conclude that further research on cost, financing, and utilization of care, by AIDS patients was well as by the population in general, will provide a necessary basis for informed formulation of health policy. Needles and Race * Atlantic (07/93) Vol. 272, No. 1, P. 38 Kirp, David L. and Bayer, Ronald Due to the reluctance by many politicians to implement needle- exchange programs, the AIDS epidemic will continue to ravage the IV-drug-using population. Several American politicians dismiss the idea of providing clean needles to drug users as "sending the wrong message" in the midst of the war on drugs. But much less attention has been given to the widespread discord within the black community, where many politicians and ministers whose constituencies have been destroyed by drugs and AIDS have been vocal opponents. It is this opposition that could be why cities most affected by the epidemic have resisted needle exchange. Stephen B. Thomas and Sandra Crouse Quinn from the University of Maryland conducted an investigation of public opinion among blacks on questions involving the AIDS epidemic. Thomas and Quinn found that among black churchgoers, one in five trusts government reports on AIDS, and two thirds entertain the possibility that "AIDS is a form of genocide against the Black race." Needle-exchange programs are viewed by those who speculate about conspiracies against blacks as a cheap and cynical substitute for the drug-treatment programs for which the government continues to refuse to pay. Black Americans and conservative politicians who oppose needle- exchange programs, proven to thwart the spread of HIV among IV- drug users, are becoming unwitting allies in exacerbating the problem of AIDS prevalence. July 29, 1993 Australian Study Says AZT Slows Progression to Full-Blown AIDS * New York Times (07/29/93), P. A20 Angier, Natalie A new study has revealed that by taking the anti-AIDS drug AZT early in the course of disease the progression toward full- blown AIDS may be substantially slowed. The study, conducted by Dr. David A. Cooper of St. Vincent's Hospital at the University of New South Wales in Syndey, Australia, along with colleagues from Europe and Australia, appears to contradict the renowned Concorde study released in the spring that showed that HIV- positive people did not receive a notable benefit by taking AZT early. However, researchers familiar with all the clinical trials of AZT said the data revealed the same basic message: AZT is a moderately useful drug that can slow the course of AIDS in some patients for a limited period of time, and it is the patient and doctor's decision whether to use the drug early or even to take AZT at all. The Australian study, published in Thursday's New England Journal of Medicine, found that in a group of 993 asymptomatic HIV-positive patients who had a CD4 count above 400 cells per cubic millimeter, those administered AZT for three years were only half as likely to progress toward AIDS as those given a placebo. The patients were identified as having crossed the line from being asymptomatic to having the disease when they began exhibiting symptoms of a suppressed immune system. Although the Concorde study detected no statistical benefit in beginning AZT therapy early to thwart disease progression, researchers pointed out that the two large trials used different parameters for determining disease progression, different follow-up periods, and different "end points" on which their conclusions were based. Related Stories: Washington Post (07/29) P. A14; Wall Street Journal (07/29) P. B6. AIDS Spreads Fastest Among Young Women * Washington Post (07/29/93), P. A1 Rensberger, Boyce Young women worldwide have the highest rate of HIV transmission, according to a report released Wednesday by the United Nations Development Program (UNDP). The findings revealed in the report can be traced to various causes, from social and behavioral factors to anatomy. As women grow older, they become less inclined to contract HIV, even though, on average, their number of sex partners increases. But men do not encounter their peak risk for HIV until they are in their late twenties and early thirties. The study found that women between the ages of 15 and 25 account for 70 percent of the 3,000 women a day who contract HIV and the 500 women a day who die of AIDS. The report discovered that men and women differ greatly on when they are at highest risk for HIV. In women, the tissue that lines the vagina and can be injured during sexual intercourse is very thin in preadolescent girls. It begins to thicken with the onset of puberty and reaches its maximum about two years after the first menstrual period. This risk for infection is most relevant for girls between the ages of 10 and 18. Another factor that puts young women at risk involves a special type of cell that rings the opening of the cervix in women in their later teens and early twenties. It is these cells that the human papilloma virus infects to cause cervical cancer and that researchers suspect HIV infects. Women are also at risk when giving birth at young ages because it makes them more exposed to microbes that can enter the vagina. The UNDP urges the development of ways to convince young women to delay the time of the first episode of sexual intercourse, to postpone the first pregnancy, and to help girls control situations in which they have sex. Red Cross Offers Courses on Care of AIDS Patients * Philadelphia Inquirer (07/29/93), P. B2 The Red Cross of Southeastern Pennsylvania is implementing a series of AIDS courses designed to reach 1,200 people who provide care to AIDS patients. The three-day courses, called "AIDS Home Care," will begin today and will be repeated throughout the year with three or four new classes each month. The courses will give friends and families of AIDS patients the information and skills to help handle the physical, psychological, and spiritual challenges of the disease. Issues covered in the courses will include nutrition, medications, legal problems, and loss and grief. The program is funded by a two-year grant from the Pew Charitable Trusts and also supported by the We the People With AIDS/HIV, Ross Laboratories, Episcopal Hospital, Misericordia Hospital, and Thomas Jefferson University Hospital. Average Cost of Treating AIDS Patients Declining * Reuters (07/27/93) (Chicago) The cost of treating AIDS patients has declined significantly over the past few years, and can be attributed to improvements in diagnosing and treating AIDS-related conditions, according to a report in Tuesday's Journal of the American Medical Association. The cost of treatment from initial HIV infection to death from a collapse of the patient's immune system is $119,274, according to the report, completed in 1992 by Fred Hellinger, an economist at the U.S. Public Health Service. He said the costs incurred by AIDS patients from the time the disease was diagnosed fell by nearly 32 percent during the period the study was performed--to $69,000 in late 1992 from $102,000 in early 1991. Hellinger said the average number of days AIDS patients spent in hospitals fell from 52 days to 35 days. In the report, Hellinger examined the average monthly medical costs of 1,164 HIV-positive individuals, 784 of whom had AIDS. The patients had an estimated lifespan of 25 months from the time of diagnosis of HIV infection. But a patient with end-stage renal disease might live five years and incur $175,000 in costs, said Hellinger, citing Medicare statistics. He concluded, "If improvements in the preventive and therapeutic care continue to slow the rate of progression from HIV infection to serious complications and reduce the intensity of treatment for (patients with AIDS), HIV may be viewed in the future as a moderately expensive, chronic illness, and not as a catastrophically expensive, fatal illness." France--AIDS * Associated Press (07/28/93) Burns, Christopher (Paris) AIDS hotlines were inundated with calls from concerned people Wednesday after the French government ordered nine tests for HIV to be taken off the market because they were less effective than newer tests. AIDS Info Service, the main nationwide toll-free line, was answering up to 400 inquiries an hour in the Paris region alone. ACT-UP demanded in a statement today that the French government launch an emergency public effort to test for HIV. The group said the authorities should urge laboratories to destroy the banned tests. The Health Ministry on Tuesday prohibited nine of the 31 HIV tests used in France, claiming they were less accurate than more modern methods. The majority of the tests were made by French companies and belong to an early generation of tests developed around 1985 to identify the presence of HIV antibodies. "There's no need to be dramatic. It's simply a way of updating the tests used," said Deputy Health Minister Philippe Douste- Blazy. He added, "The withdrawn tests aren't bad, but they're less effective." The tests that are prohibited include Vironostika and Vironostika Anti HTLV3 LAV, made by Organon; Elavia, Rapid Elavia, and Genie HIV1-HIV2 by Diagnostics Pasteur; Cobas Core by Roche; Enzynum Test by Boehringer; ImmunoComb PBS by Organics; and Rapid by Clonatec. Also, six other tests made by Diagnostics Pasteur, Behring, Coultronics, and Sorin-France are now limited to use by blood banks and only when a back-up test is used. The withdrawal order involves only France and its overseas territories. Other countries that might be using the tests could not be identified by a Health Ministry spokeswoman. State of Denial * Advocate (07/27/93) No. 634, P. 44 Gallagher, John Alabama state laws regarding HIV are among the worst nationwide. Doctors in the state may test for HIV without the patient's permission, and Alabama state prisoners are tested automatically for the virus and HIV-positive inmates are separated from the general population. Sex-education instructors are required to emphasize abstinence and to inform their classes Alabama law forbids homosexuality. In addition, an amendment to a 1975 Alabama state law permits health authorities to disclose HIV status to a number of people, including education superintendents, funeral directors, and health care workers. The amendment was scaled down from the law originally proposed, which would have allowed HIV status to be disclosed to any individual. Active AIDS Surveillance: Hospital-Based Case Finding in a Metropolitan California County * American Journal of Public Health (07/93) Vol. 83, No. 7, P. 1,002 Elcock, Maryellen; Simon, Tamara; Gilbert, Bradley P.; Copello, Gene; and Kelzer, Pauline J. Health departments that rely solely on passive surveillance are not guaranteed their reported level of AIDS cases will be correct. Therefore, the authors attempted to create an example of active AIDS cases reporting that use resources available to county workers. To achieve the model, the authors conducted a validation study of AIDS cases reporting. The study was used to determine the level of underreporting. The authors then created hospital-specific protocols for use in active surveillance. The study indicated 24 percent of AIDS cases in all hospitals together were not identified through passive surveillance in 1990. In addition, nine unreported cases, or 69 percent of the total reported cases, were discovered through active surveillance in the first three months of 1991. The Centers for Disease Control estimates underreporting rates nationwide to be 15 percent. Commission Report: 'AIDS: An Expanding Tragedy' * Journal of the American Medical Association (07/21/93) Vol. 270, No. 3, P. 298 Marwick, Charles The National Commission on Acquired Immune Deficiency Syndrome has concluded the current indifference and fear to AIDS must be stopped, or else the virus will be responsible for an unprecedented number of deaths among young Americans. The projection was included in a recent commission report written by Dr. David E. Rogers and Dr. June E. Osborn. Currently, AIDS is the leading cause of death for men age 25 to 44 in more than 60 U.S. cities. AIDS commission officials say their previous warnings and recommendations have been ignored or underfunded to date. "The human immunodeficiency virus (HIV) has profoundly changed life on our planet. America has not done well in acknowledging this fact or in mobilizing its vast resources to address it appropriately," the report states. The authors offer two recommendations in the report. First, all leaders must discuss AIDS with their constituents. Second, a national plan for dealing with AIDS must be developed. Pneumocystis Carinii Pneumonia Among US Children with Perinatally Acquired HIV Infection * Journal of the American Medical Association (07/28/93) Vol. 270, No. 4, P. 470 Simonds, R. J.; Oxtoby, Margaret J.; Caldwell, M. Blake; et. al. R. J. Simonds and associates have monitored children ages zero to 12 years and women of childbearing years to determine epidemiologic traits of pneumocystis carinii pneumonia (PCP) among children with perinatally acquired HIV. The scientists obtained data from surveillance done by state and local health departments and submitted to the Centers for Disease Control and Prevention from 1982 to 1992. Of the 3,665 perinatally AIDS cases reported, 1,374 listed PCP. More than 50 percent of these cases happened in babies three and six months old. The researchers concluded that PCP is widespread in young children with HIV. July 30, 1993 AIDS Drug Might Use 'Buckyballs' * Los Angeles Times--Washington Edition (07/30/93), P. B1 Stolberg, Sheryl What started as a joke treatment for HIV may actually be effective in stopping the virus from multiplying in the test tube. Simon Friedman, a 27-year-old graduate student in pharmaceutical chemistry at the University of California--San Francisco, was recently discussing with his colleague, Diane Roe, ways in which researchers were trying to thwart HIV in the test tube. Then Roe quipped, "What are they gonna try next? Buckyballs?" But the joke turned out to be a potential method of inhibiting HIV's spread in the test tube. Friedman says that buckyballs--recently discovered molecules so nicknamed because their shape resembles the late R. Buckminster Fuller's multi- sided geodesic domes--do indeed stop HIV from multiplying. The finding is published in this week's Journal of the American Chemical Society and seems to be the first biological application of buckyballs. The molecules function by inhibiting a crucial enzyme. Friedman hopes buckyballs can be the first step toward creating a successful protease inhibitor. Buckyballs, also known as fullerenes or C-60, are hollow, soccer-ball shaped molecules composed of 60 carbon atoms. They comprise a third, newfound type of pure carbon. Friedman said the thought occurred to him that their unique shape might enable buckyballs to fit into the space that protease normally uses to attach to a crucial protein. The computer model was encouraging so he later checked his findings in the test tube. Because the development of a protease inhibitor using buckyballs is a long way off, Friedman said, "we have to be willing to accept lesser goals--i.e. that we are moving in the right direction." African Nations Brace for Economic Impact of AIDS * Christian Science Monitor (07/30/93), P. 8 Press, Robert Africa has more than half of the world's AIDS cases, which will eventually affect developing nations' economies, according to two recent studies by the World Bank on AIDS in Africa. Officials from Kenya said that the AIDS epidemic in Africa has both a personal dimension for individuals and an economic one for the whole population. Michael Merson, director of the AIDS program for the World Health Organization, said that the current problems affecting Africa may also soon be felt in Asia. By the year 2000, Asia may have a higher annual rate of HIV infection than Africa, said Merson. He is requesting $3 billion for an AIDS prevention program in developing countries, which he says could halve the expected deaths from AIDS by the end of the decade. World Bank economist Dean Jamison says the $3 billion is only a fraction of the $170 billion spent on health care each year in the developing world. Jamison claims that significant steps have been taken in extending life expectancy in the developing nations. However, without an aggressive AIDS prevention program, these gains could be lost, he added. According to Gilbert Jimbo, manager of Kenya's National AIDS Control Program, AIDS patients occupy up to 60 percent of the nation's hospital beds in some areas. "The impact of AIDS on the economy in Kenya will be the loss of 22 years of the patients' lives, which will cause a shortfall of between 6 percent and 15 percent in gross domestic product by the year 2000," said Jimbo. AIDS Dilemma Remains Despite Positive AZT Study * Reuters (07/29/93) Johnson, Cynthia (London) Decisions on whether to use AZT early in the course of HIV infection should not be based on findings from a single report, analysts said Thursday. The European-Australian study featured in the New England Journal of Medicine concurred with earlier research that showed that early treatment of HIV- positive patients with AZT slowed the progression to full-blown AIDS. Nick Partridge, chief executive of Britain's leading AIDS charity The Terrence Higgins Trust, said, "This trial should not be looked at on its own but together with the 13 other studies already available about the use of AZT." One of the studies is the Concorde study, which found that early use of AZT may not be very effective in staving off full-blown AIDS. The European-Australian study was led by Dr. David Cooper of the University of New South Wales in Sydney and involved 1,000 patients, all of whom had CD4 cell counts of 400 or higher. The Concorde trial also discovered that patients taking AZT before the onset of AIDS symptoms had higher numbers of CD4 cells, but determined that this had no noticeable impact on the eventual course of the disease. "The main finding of the [Cooper] study is something we have known for a long time, that zidovudine [AZT] increases the CD4 cell count," said Ian Weller, the British coordinator for Concorde. Analysts noted that the Cooper study involved only people with fairly high CD4 counts, whereas those in Concorde ranged from very high to very low. They said that even in Concorde, among the 710 patients with CD4s above 500 before entry, there was a trend toward some benefit of early AZT treatment. Germany--AIDS--Hemophiliacs * Associated Press (07/28/93) Allen, Arthur Bonn, Germany--Prompted by the outcome of the tainted blood scandal in France, HIV-positive German hemophiliacs have demanded compensation and an investigation into the country's blood supply. In a statement from the Hemophiliacs Society, German hemophiliacs, who consist of about 7,500 people, are calling for compensation for the 25 percent who contracted HIV and 300 who subsequently died. Approximately 50 people protested at the Health Ministry Monday and requested up to $216,000 for each individual infected through the blood supply. While four French officials were convicted and the reputation of the Socialist government was destroyed last year because of charges of the distribution of tainted blood through federal blood banks, the blood banks in Germany are private. Health Ministry official Franz-Josef Bindert said, "Officials acted within the constraints of what was scientifically known. In hindsight, they could have done better, but they aren't liable." The Hemophiliacs Society prepared a study that criticized the German government for neglect and cited a slow reaction time by health authorities, which contributed to the infection of many hemophiliacs between 1983 and 1985. Although a test for the presence of HIV in blood only became available in 1985, tests for hepatitis antibodies, carried by more than 80 percent of HIV-positive blood donors, were available by 1981. There was no general recall of blood products, and tainted blood products continued to be used in some cases into 1986. Canada Watch: Activists Fight Deportation * Toronto Globe and Mail (Canada) (07/29/93), P. A4 Canadian AIDS activists carried two imitation coffins to federal immigration offices on Wednesday to protest against the deportation of a Salvadorean woman, who is being ordered out of the country solely because she is infected with HIV. Clara Palacios must leave Canada on Saturday along with her 10-month- old son. Approximately 50 members of ACT-UP carried the coffins to represent what they believe will be the imminent death of the two in El Salvador. The Long Shot * Discover (08/93) Vol. 14, No. 8, P. 6 * Caldwell, Mark When researchers discovered that AIDS was a virus in 1984, they believed that a vaccine could be developed in as little as two years. But although many prototype vaccines are now beginning to reach the human testing stage, researchers have become wary of claiming to have found a cure for AIDS. Over the past decade they have learned more, more quickly, than was ever known about other types of viral infections for which cures were discovered. But what they have found is that the AIDS virus doesn't follow the usual rules. It is a retrovirus, meaning that it can go undetected for a long time, and when it finally strikes, it attacks the very thing that is supposed to help the body fight disease: the immune system. Another problem hindering the discovery of a cure is that there are dozens of different known strains of HIV, and the virus can mutate within one patient. Dental Treatment and HIV Positivity * Lancet (07/10/93) Vol. 342, No. 8863, P. 119 Zakrzeweska, J.; Robinson, P.; and Croucher, R. People with HIV have special needs for dental care because, along with typical oral diseases, they may have particular oral conditions caused by the infection. Yet, HIV patients have difficulties getting proper dental care. One study found that of 146 HIV-infected men, 30 percent stopped going to their dentist because they feared refusal or negative attitudes. Of those who did visit their dentist, only 50 percent revealed their condition, and half of that group were refused treatment. Laboratory Methods for Diagnosing and Monitoring HIV Infection * Journal of the Association of Nurses in AIDS Care (04/93-06/93) Vol. 4, No. 2, P. 11 Grady, Christine) The four types of laboratory tests relating to HIV include: tests for antibody to HIV; tests for quantifying the presence of HIV; tests to monitor the progression of the disease; and tests to monitor immune status. The most common antibody test is the enzyme-linked immunosorbent assay (ELISA). Others are Western blot, immunofluorescence, radioimmunoprecipitation, and hemagglutination. Although these tests only measure the antibody to HIV -- not the presence of the virus -- any person found to have antibody to HIV is considered infected, according to the Centers for Disease Control and Prevention's definition of AIDS. The only test approved by the Food and Drug Administration to determine the presence of the virus is the p24 antigen capture assay. Unfortunately, p24 assay identifies as few as four percent of asymptomatic infected individuals and 70 percent of AIDS patients. Due to its lack of sensitivity, the p24 assay is not recommended as a screening test. Other tests for the presence or amount of the virus are HIV culture/coculture and polymerase chain reaction. Tests for monitoring the progression of HIV disease are often called surrogate markers or prognostic indicators. Researchers have not reached a consensus on which surrogate markers are best, although many say a combination of tests yields the most accurate results. Beta-2 microglobin and serum neopterin are popular surrogate markers because they are inexpensive, easy to measure, and widely available. Since HIV causes changes in the immune function, patients' immunosuppression should be tested by evaluations of white blood cells, lymphocytes, T4 cell number, T-cell function, and B cells. The Lifetime Cost of Treating a Person with HIV * Journal of the American Medical Association (07/28/93) Vol. 270, No. 4, P. 474 Hellinger, Fred J. Fred J. Hellinger has used information from the AIDS Cost and Service Utilization Survey to determine the estimated expense of medical care for people with HIV from the time of infection until death. Hellinger studied information from interviews conducted during the spring and early summer of 1992 with 1,164 HIV patients. San Francisco Men's Health Study provided estimates of the mean occupancy time in each of the four disease phases, and then these numbers were multiplied by the monthly cost in each stage. After that, Hellinger added the figures to come up with a synthetic estimate of the lifetime medical care costs of treating a person with HIV. Hellinger concluded that the lifetime cost of treating a person with AIDS has declined as a result of a decrease in using inpatient hospital services, costing approximately $119,000. NOTE: Compilation by Michael Tidmus : AIDSwire. All rights reserved. Permission is granted to republish on electronic media for which no fee is charged, provided the complete text of this notice is attached to any republished portion or portions. * From the AIDS Daily Summary. The Centers for Disease Control and Prevention (CDC) National AIDS Clearinghouse has made this information available as a public service only. Providing this information does not constitute endorsement by the CDC, the CDC Clearinghouse, or any other organization. Reproduction of this text is encouraged; however, copies may not be sold. Copyright 1993, Information, Inc., Bethesda, MD. -----===[[[ A I D S w i r e D I G E S T 07.26.93 ]]]===----- .