(:source :version 3 :ip-address "137.132.3.3" :ip-name "solomon.technet.sg" :tcp-port 210 :database-name "prosite" :cost 0.00 :cost-unit :free :maintainer "waisguy@solomon.technet.sg" :description " Server created with WAIS release 8 b3.1 on Feb 8 17:35:37 1992 by waisguy@solomon.technet.sg The files of type dash used in the index were: /home/waisguy/src/prosite-db ###### ###### ### #### #### ###### ####### ## ## ## ## ## ## ## ## ## # ## # ## # ## ## ## ## ## ## ### ## ## ## # ##### ##### ## ## ### ## ## #### ## ## ## ## ## ### ## ## ## # ## ## ## ## ## ## ## ## ## ## # #### ### ## ### #### #### #### ####### PROSITE: A DICTIONARY OF PROTEIN SITES AND PATTERNS Release 8.00, December 1991 Amos Bairoch Medical Biochemistry Department Centre Medical Universitaire 1211 Geneva 4 Switzerland Telephone: (+41 22) 61 84 92 Electronic mail address: bairoch@cgecmu51.bitnet or bairoch@cmu.unige.ch The use of protein sequence patterns (or motifs) to determine the function(s) of proteins is becoming very rapidly one of the essential tools of sequence analysis. This reality has been recognized by many authors including well known experts of protein sequence analysis, R.F. Doolittle and A.M. Lesk. PROSITE is a compilation of sites and patterns found in protein sequences. Some of these patterns been published in the literature, but the majority have been developed, in the last two years, by the author. Originally this dictionary was conceived as part of the author's doctoral dissertation as well as an integral part of the PROSITE program in the PC/Gene sequence analysis software package. But, as many people have expressed their interest in this project, we have decided to make this work available on computer media as well as in a printed form. If you want to refer to PROSITE in a publication you can do so by citing: Bairoch A. PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res. 19:2241-2245(1991). This release of PROSITE contains 530 documentation entries that describe 605 different patterns including: Post-translational modifications Electron transport proteins Domains Other transport proteins DNA or RNA associated proteins Structural proteins Enzymes Receptors Oxidoreductases Cytokines and growth factors Transferases Hormones and active peptides Hydrolases Toxins Lyases Other proteins Isomerases Ligases Other Enzymes This WAIS source of the PROSITE dictionary has been created with the permission of Dr Amos Bairoch by Dr Tin Wee TAN, Dept of Biochemistry, (INTERNET: bchtantw@nuscc.nus.sg BITNET: bchtantw@nusvm.bitnet) and Dr Derek Kiong, Dept of Information Systems and Computer Science (isckbk@nuscc.nus.sg) National University of Singapore, Kent Ridge, Singapore 0511, and maintained on the Singapore TECHNET Unix at solomon.technet.sg (137.132.3.3). Newcomers are advised to use the keywords 'PROSITE' or 'help' or 'documentation' to find out more about the PROSITE dictionary. (Please see the section below on 'Additional Hints'.) For a list of where you can obtain the PROSITE database, please use the keywords 'obtain' or 'get'. For a list of software/programs that make use of PROSITE, please use the keywords 'software' or 'program'. For a detailed explanation of how this source was indexed, use the keyword 'WAISINDEX' to retrieve the entry or consult bchtantw@nuscc.nus.sg or isckbk@nuscc.nus.sg. Comments are warmly welcomed. For questions relating to the content of the PROSITE dictionary, you are requested to direct your queries to the copyright author of PROSITE, Dr Amos Bairoch (address given above). The entire database or entries within the database may be copied and redistributed freely, without advance permission, provided that its textual content is not modified. ADDITIONAL HINTS for getting the best out of this WAIS service. --------------------------------------------------------------- 1) Use a general term for an initial search. Eg if looking for chymotrypsin, start with protease. 2) Be careful when using the PDOC numbers. Note that the O is not the same as 0. 3) Because of the indexing software, keyword 'chymotrypsin', for instance, may not pick up entries without the exact word 'chymotrypsin', even though the word 'chymotrypsins' may be present. 4) To understand the way the entries are structured, please read the PROSITE documentation (keywords PROSITE documentation help). " ) .